2020
DOI: 10.1016/j.jff.2020.104171
|View full text |Cite
|
Sign up to set email alerts
|

An overview of Neem (Azadirachta indica) and its potential impact on health

Help me understand this report
View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
83
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
6
2
1

Relationship

0
9

Authors

Journals

citations
Cited by 161 publications
(85 citation statements)
references
References 72 publications
2
83
0
Order By: Relevance
“…The two types of melanization in our study (Fig 3b and 3c) can be explained by the fact that the high concentrations of the extracts are poorly distributed within the larvae unlike the low concentrations. In addition, similarly to our study, seeds of A. indica have been reported to have high toxicity both in animal models [52] and in insects [53] due to phytochemicals that it contains, including azadirachtin, which is used in the composition of certain natural insecticides [14]. This substance acts mainly by blocking metamorphosis from the larval to adult stage and paralyzes the digestive tract of the larva [14,15].…”
Section: Resultssupporting
confidence: 82%
“…The two types of melanization in our study (Fig 3b and 3c) can be explained by the fact that the high concentrations of the extracts are poorly distributed within the larvae unlike the low concentrations. In addition, similarly to our study, seeds of A. indica have been reported to have high toxicity both in animal models [52] and in insects [53] due to phytochemicals that it contains, including azadirachtin, which is used in the composition of certain natural insecticides [14]. This substance acts mainly by blocking metamorphosis from the larval to adult stage and paralyzes the digestive tract of the larva [14,15].…”
Section: Resultssupporting
confidence: 82%
“…This new approach can promote the development of innovative and technological natural-based medications improving the exploitation of traditional medicine. Neem oil has been widely used in traditional medicine for the treatment of various disorders, especially those affecting the skin [ 58 ]. However, its use is limited especially because of its low bioavailability along with its characteristic and unpleasant smell, defined as a combination of peanuts and garlic [ 59 ].…”
Section: Discussionmentioning
confidence: 99%
“…It is isolated from the leaves and flowers of a traditional medicinal plant, Azadirachta indica (Neem). Besides nimbolide, other limonoids such as azadirachtin, nimbidin, and epoxyazadiradione have also shown various beneficial therapeutic activities, including anti‐inflammatory, and anticancer 3‐11 . Notably, available reports suggest that among all the limonoids, nimbolide is the most potent anticancer agent 12 …”
Section: Introductionmentioning
confidence: 99%
“…Besides nimbolide, other limonoids such as azadirachtin, nimbidin, and epoxyazadiradione have also shown various beneficial therapeutic activities, including anti-inflammatory, and anticancer. [3][4][5][6][7][8][9][10][11] Notably, available reports suggest that among all the limonoids, nimbolide is the most potent anticancer agent. 12 Numerous in vitro and in vivo studies have demonstrated the promising therapeutic efficacy of nimbolide against breast, colon, prostate, pancreatic, cervical, renal, and oral cancers.…”
mentioning
confidence: 99%