An overview of neurobiological comparisons in mouse strains

Ingram, Donald K.; Corfman, Timothy P.

doi:10.1016/0149-7634(80)90032-9

Cited by 109 publications

(22 citation statements)

References 68 publications

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“…The D2 mice had far lower levels of fear related behaviour compared with B6, which is consistent with this strain having a fear memory deficit. This difference in behaviour is supported by literature indicating differences in hippocampal function and hippocampal protein kinase C (Paylor et al 1993;Bowers et al 1995), brain morphology (Ingram and Corfman 1980), and biochemistry (Fordyce and Wehner 1992;Bowers et al 1995) fos expression (Passino et al 2002) and electrophysiology (Wang and Chow 1994) between the two strains.…”

Section: Discussionsupporting

confidence: 60%

Congenic Mouse Strains Enable Discrimination of Genetic Determinants Contributing to Fear and Fear Memory

et al. 2010

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The ability to learn and remember is variable within a population of a given species, including humans. This is due in part to genetic variation between individuals. However, only few genes have been identified that contribute to variation in learning and memory. Two inbred mouse strains, C57Bl/6J (B6) and DBA/2J (D2), show significant variation both in fear conditioning memory as well as primary responsiveness to fear. Several studies have identified quantitative trait loci (QTL) on chromosomes (Chr) 1 and 12 associated with performance in fear conditioning, but it is unclear if these QTL were associated with fear memory or innate fear responsiveness. To determine if these QTL are associated with fear memory or fear responsiveness, we studied congenic mouse strains harbouring D2-derived DNA from Chr1 or Chr12 on a B6 genetic background. Cohorts of D2, B6 and the congenic mice were tested throughout the process of fear conditioning by measuring a series of fear-related parameters. The Chr1 congenic mice showed clear deficits in fear memory compared to B6 mice, which established the presence of a QTL on Chr1 directly influencing fear memory. The Chr12 congenic mice also showed alterations in fear conditioning, but this was more associated with alterations in fear responsiveness. These findings thus provide evidence for the localisation of independent genetic determinants for fear memory and fear responsiveness.

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Section: Discussionsupporting

confidence: 60%

Congenic Mouse Strains Enable Discrimination of Genetic Determinants Contributing to Fear and Fear Memory

et al. 2010

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“…Low learning capacity of BALB/c mice in the water maze can be explained by decreased basal level of acetylcholine in the cortex, hippocampus, and nigrostriatal system [11]. Scopolamine administration aggravates the cholinergic deficit and impairs learning ability in water Morris test.…”

Section: Resultsmentioning

confidence: 99%

“…Experiments were performed on male BALB/c mice (n=63) characterized by low concentration of acetylcholine in the hippocampus and cerebral cortex and high sensitivity to drugs impairing cholinergic transmission [11]. The animals (20-23 g) were obtained from Stolbovaya nursery (Russian Academy of Medical Sciences) and maintained in plastic cages (30×70×40 cm, 6-8 mice per cage) under natural light/dark conditions.…”

Section: Methodsmentioning

confidence: 99%

Dipeptide preparation Noopept prevents scopolamine-induced deficit of spatial memory in BALB/c mice

2007

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The effect of original nootropic preparation Noopept on learning and long-term memory was studied with BALB/c mice. Scopolamine (1 mg/kg) impaired long-term memory trace, while Noopept (0.5 mg/kg) had no significant effect. Noopept completely prevented the development of cognitive disorders induced by scopolamine (blockade of muscarinic cholinergic receptors). Our results confirmed the presence of choline-positive effect in dipeptide piracetam analogue Noopept on retrieval of learned skill of finding a submerged platform (spatial memory). We conclude that the effectiveness of this drug should be evaluated in patients with Alzheimer's disease.

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“…One of these characteristics is the level of cerebral neurotransmitter metabolism [7]. On the other hand, 101/HY mice are little studied as the object of research in physiological experiments, in contrast to DBA/2J strain.…”

Section: Resultsmentioning

confidence: 99%

Audiogenic epilepsy in young mice of different strains after neonatal semax treatment

et al. 2008

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An overview of neurobiological comparisons in mouse strains

Cited by 109 publications

References 68 publications

Congenic Mouse Strains Enable Discrimination of Genetic Determinants Contributing to Fear and Fear Memory

Congenic Mouse Strains Enable Discrimination of Genetic Determinants Contributing to Fear and Fear Memory

Dipeptide preparation Noopept prevents scopolamine-induced deficit of spatial memory in BALB/c mice

Audiogenic epilepsy in young mice of different strains after neonatal semax treatment

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