An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis

Sowndhararajan, Kandhasamy; Deepa, Ponnuvel; Kim, Minju; Park, Se Jin; Kim, Songmun

doi:10.1016/j.biopha.2017.10.145

Cited by 122 publications

(54 citation statements)

References 85 publications

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“…In the present study, we analyzed the beneficial effects of SCE and AA on mitochondrial respiration and behavior. SCE is enriched for a number of bioactive ingredients, including gomisin and schisandrin, as confirmed by HPLC ( Figure S1), and is known to enhance cognitive performance and provide neuroprotection [10,13,29]. AA is present in various plants and is used as a dietary supplement.…”

Section: Discussionmentioning

confidence: 86%

Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice through Modulation of Mitochondrial Respiration

Jang

Lee

et al. 2020

Nutrients

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Cognitive decline is observed in aging and neurodegenerative diseases, including Alzheimer’s disease (AD) and dementia. Intracellular energy produced via mitochondrial respiration is used in the regulation of synaptic plasticity and structure, including dendritic spine length and density, as well as for the release of neurotrophic factors involved in learning and memory. To date, a few synthetic agents for improving mitochondrial function have been developed for overcoming cognitive impairment. However, no natural compounds that modulate synaptic plasticity by directly targeting mitochondria have been developed. Here, we demonstrate that a mixture of Schisandra chinensis extract (SCE) and ascorbic acid (AA) improved cognitive function and induced synaptic plasticity-regulating proteins by enhancing mitochondrial respiration. Treatment of embryonic mouse hippocampal mHippoE-14 cells with a 4:1 mixture of SCE and AA increased basal oxygen consumption rate. We found that mice injected with the SCE-AA mixture showed enhanced learning and memory and recognition ability. We further observed that injection of the SCE-AA mixture in mice significantly increased expression of postsynaptic density protein 95 (PSD95), an increase that was correlated with enhanced brain-derived neurotrophic factor (BDNF) expression. These results demonstrate that a mixture of SCE and AA improves mitochondrial function and memory, suggesting that this natural compound mixture could be used to alleviate AD and aging-associated memory decline.

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Section: Discussionmentioning

confidence: 86%

Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice through Modulation of Mitochondrial Respiration

Jang

Lee

et al. 2020

Nutrients

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“…SC is frequently used in China, Korea, and Japan as a tonic for kidney and a treatment for alleviating various symptoms of cognitive deficits and facilitating learning and memory for thousands of years [35]. Recent experience from clinic and laboratory supported the notion that SC was safe and effective in improving cognitive function and reversing cycloheximide-induced amnesia in rats [36].…”

Section: Discussionmentioning

confidence: 99%

In Vitro and In Vivo Anti‐AChE and Antioxidative Effects of Schisandra chinensis Extract: A Potential Candidate for Alzheimer’s Disease

Song

Wang

Guo

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Acetylcholinesterase (AChE) inhibition and antioxidants are two common strategies for the treatment in the early stage of Alzheimer’s Disease (AD). In this study, extracts from nine traditional Chinese medical (TCM) herbs were tested for anti-AChE activity by Ellman’s microplate assay and cytotoxicity by CCK-8. Based on its excellent AChE inhibition effect and its lowest cytotoxicity, Schisandra chinensis (SC) extract was selected to do the mechanism research. SC extract protected pheochromocytoma (PC12) cells against H2O2-induced toxicity by improving the cell survival rate in a dose-dependent manner. And it also showed significant free radical (DPPH) scavenging activities, ferric reducing antioxidant power (FRAP), and 2,2′-Azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging. To confirm these results, the scopolamine-induced mice models were utilized in this study. Compared with the positive drug (piracetam), SC could also exhibit similar effects to alleviate the mice’s cognitive deficits. Moreover, in the mice brain samples, the AChE activity and malondialdehyde (MDA) levels of SC-treatment group both showed a reverse as compared to model group. Taken together, these results all suggested that SC extract may be a potential therapeutic candidate for AD.

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“…Schisandra chinensis ( Turcz .) Baill ., Schisandraceae, was distributed in northeast China, Japan and Korea, and it has been widely used against hepatitis, diabetes, diarrhea and insomnia . S. chinensis has been extensively studied because of its high medicinal and health functions.…”

Section: Introductionmentioning

confidence: 99%

Lignans and Terpenoids from the Leaves of Schisandra chinensis

Liu

Sun

et al. 2020

Chemistry & Biodiversity

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Fifteen constituents, including one new lignan (schisandroside E) and one new terpenoid (schisandenoid A) as well as nine known lignans and four known terpenoids, were isolated from Schisandra chinensis leaves. The structures of schisandroside E and schisandenoid A were established by entirely meticulous spectroscopic analysis (NMR, MS, CD, IR and UV). All compounds were tested for cytotoxicity against MGC-803, Caco-2 and Ishikawa cell lines. Some compounds showed strong cytotoxicity against these three cancer cell lines with IC 50 < 1 μM.

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An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis

Cited by 122 publications

References 85 publications

Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice through Modulation of Mitochondrial Respiration

Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice through Modulation of Mitochondrial Respiration

In Vitro and In Vivo Anti‐AChE and Antioxidative Effects of Schisandra chinensis Extract: A Potential Candidate for Alzheimer’s Disease

Lignans and Terpenoids from the Leaves of Schisandra chinensis

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