2022
DOI: 10.7759/cureus.25032
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An Overview of Parkinson's Disease: Curcumin as a Possible Alternative Treatment

Abstract: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain and basal ganglia, followed by dopamine deficiency in the brain. Dopamine plays a crucial role in motor coordination, memory, and cognition; its decrease in PD leads to dyskinesia, cognitive deficits, and depression. In addition, the formation of alpha-synuclein protein aggregates (Lewy bodies) causes further damage to the CNS. Current treatment options include dopa… Show more

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Cited by 9 publications
(6 citation statements)
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“…Conversely, curcumin administration at a dose of 100 mg/kg attenuated brain oxidative stress when compared to the CPZ and SR groups. In support of these findings, it has been shown that curcumin alleviates oxidative injury of the nervous system in models of Alzheimer’s disease [ 54 ], epilepsy [ 55 ] and Parkinson’s disease [ 56 ].…”
Section: Discussionmentioning
confidence: 83%
“…Conversely, curcumin administration at a dose of 100 mg/kg attenuated brain oxidative stress when compared to the CPZ and SR groups. In support of these findings, it has been shown that curcumin alleviates oxidative injury of the nervous system in models of Alzheimer’s disease [ 54 ], epilepsy [ 55 ] and Parkinson’s disease [ 56 ].…”
Section: Discussionmentioning
confidence: 83%
“…Research findings have shown that curcumin has the ability to downregulate the level of the caspase-3 enzyme, besides amplifying the LRRK2 mRNA and protein expression in vitro. Accumulated evidence showed that curcumin exhibits various neuroprotective properties, including chelating metal ions' antioxidation, inhibition of the aggregation of misfolded proteins, and attenuating neuroinflammation [167,168]. According to Jin et al, curcumin was found to alleviate PD by energizing the BDNF/PI3k/Akt transduction pathway [169].…”
Section: Curcuminmentioning
confidence: 99%
“…Additionally, it prevents α-syn E46K and H50Q mutants that are linked to PD illness from aggregating amyloid under phase separation. Curcumin can also weaken α-syn amyloid aggregates that have already developed in the condensates [167,168].…”
Section: Curcuminmentioning
confidence: 99%
“…Huan Peng et al constructed a nanocarrier for nasal administration with exosomes derived from mesenchymal stem cells (MSCs), which have a therapeutic effect on PD by themselves, mainly due to the presence of micro RNAs (miRNAs) and proteins [ 158 ]. In addition, they utilized curcumin, which can inhibit the aggregation of α-synuclein and reduce the toxicity of aggregates to dopaminergic neurons [ 159 ]. Moreover, SPIONs were also assembled to be used as magnetic resonance imaging contrast agents for the purpose of tracking the accumulation of nanocarriers in the brain.…”
Section: Nanoformulations As Therapy For Central Nervous System Diseasesmentioning
confidence: 99%