An overview of phospholipid enriched-edge activator-based vesicle nanocarriers: new paradigms to treat skin cancer

Jahan, Samreen; Ali, Asad; Sultana, Niha; Qizilbash, Farheen Fatima; Ali, Hamad; Aqil, Mohd.; Mujeeb, Mohd.; Ali, Asgar

doi:10.1080/1061186x.2024.2402750

Journal of Drug Targeting

2024

DOI: 10.1080/1061186x.2024.2402750

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An overview of phospholipid enriched-edge activator-based vesicle nanocarriers: new paradigms to treat skin cancer

Samreen Jahan,

Asad Ali,

Niha Sultana

et al.

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2024

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Cited by 1 publication

References 150 publications

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Transdermal Delivery of Ultradeformable Cationic Liposomes Complexed with miR211-5p (UCL-211) Stabilizes BRAFV600E+ Melanocytic Nevi

Chhibber,

Scherzer,

Prokofyeva

et al. 2024

Preprint

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Small non-coding RNAs (e.g. siRNA, miRNA) are involved in a variety of melanocyte-associated skin conditions and act as drivers for alterations in gene expression within melanocytes. These molecular changes can potentially affect the cellular stability of melanocytes and promote their oncogenic transformation. Thus, small RNAs can be considered as therapeutic targets for these conditions, however, their topical delivery to the melanocytes through the epidermal barrier is challenging. We synthesized and extensively evaluated ultradeformable cationic liposome (UCLs) carriers complexed with synthetic microRNAs (miR211-5p; UCL-211) for transdermal delivery to melanocytes. UCL-211 complexes were characterized for their physicochemical properties, encapsulation efficiency, and deformability, which revealed a significant advantage over conventional liposomal carriers. Increased expression of miR211-5p stabilizes melanocytic nevi and keeps them in growth-arrested state. We did a comprehensive assessment of cellular delivery, and biological activity of the miR211-5p carried by UCL-211in vitroand their permeation through the epidermis of intact skin usingex vivohuman skin tissue explants. We also demonstrated,in vivo, that topical delivery of miR211-5p by UCL-211 stabilized BRAFV600E+ nevi melanocytes in a benign nevi state.

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Transdermal Delivery of Ultradeformable Cationic Liposomes Complexed with miR211-5p (UCL-211) Stabilizes BRAFV600E+ Melanocytic Nevi

Chhibber,

Scherzer,

Prokofyeva

et al. 2024

Preprint

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An overview of phospholipid enriched-edge activator-based vesicle nanocarriers: new paradigms to treat skin cancer

Cited by 1 publication

References 150 publications

Transdermal Delivery of Ultradeformable Cationic Liposomes Complexed with miR211-5p (UCL-211) Stabilizes BRAFV600E+ Melanocytic Nevi

Transdermal Delivery of Ultradeformable Cationic Liposomes Complexed with miR211-5p (UCL-211) Stabilizes BRAFV600E+ Melanocytic Nevi

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