2021
DOI: 10.1080/10837450.2021.1944207
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An overview of PLGA in-situ forming implants based on solvent exchange technique: effect of formulation components and characterization

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Cited by 25 publications
(14 citation statements)
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“…Upon administration, the solvent diffuses into surrounding tissues, forming a solid or semisolid drug delivery depot comprising the peptide and sustained-release matrix. This transformed depot exhibits prolonged residence at the injection site, facilitating sustained drug release [ 40 , 41 ].…”
Section: Discussionmentioning
confidence: 99%
“…Upon administration, the solvent diffuses into surrounding tissues, forming a solid or semisolid drug delivery depot comprising the peptide and sustained-release matrix. This transformed depot exhibits prolonged residence at the injection site, facilitating sustained drug release [ 40 , 41 ].…”
Section: Discussionmentioning
confidence: 99%
“…Herein, a relatively closed aqueous channel is formed for loading growth factors and the formed LLC fits the non-smooth wound surface. Moreover, a hypoxic environment is created by the physical occultation, which can avoid the degradation of encapsulated drugs in contact with external water and oxygen molecules [ 67 ].…”
Section: Lyotropic Liquid Crystalline Might Be a Promising Candidate ...mentioning
confidence: 99%
“…Polymers are an integral component for various biomedical applications, including drug delivery, tissue engineering, and implants. In the field of controlled drug delivery, nondegradable polymers like polyacrylates, cellulose, and polyethylene glycol are compatible with oral and topical administration, whereas degradable poly­(lactic- co -glycolic acid) (PLGA) is an ideal candidate for parenteral controlled release. Of all biopolymers, PLGA is distinct for its superior biocompatible nature and highly tunable biodegradability . The mechanism of this chemically controlled drug delivery process is that an active pharmaceutical ingredient (API) is mixed in the polymer matrix, and the slow diffusion and polymer degradation in vivo results in the gradual release of the API …”
Section: Introductionmentioning
confidence: 99%