An overview of polymyositis and dermatomyositis

Dermatomyositis sine dermatitis, a rare phenotype of idiopathic inflammatory myopathy

“…The prevalence of DM sine dermatitis is not known, but a recent retrospective study of DM indicated a prevalence of approximately 15% [5]. However these data should be considered cautiously as they showed a much lower prevalence of amyopathic DM of 2%, which is inconsistent with the results of other studies that showed a prevalence rate of 10-20% [4,6]. Moreover, only one case described the clinical and pathological status of DM sine dermatitis in detail [7].…”

A Case of Polymyositis Associated with Immunoglobulin A Nephropathy

“…Otherwise, PM-associated IgA nephropathy is relatively uncommon. The histopathological features of PM include myofiber injury caused by macrophages and activated CD8+ cytotoxic T cells that attack non-necrotic muscle fibers expressing class I major histocompatibility complex (MHC-I) [6][7][8]. Patients with IgA nephropathy are reported to be relatively deficient in suppressor T-cell activity and to have hyperactive IgA-specific helper T-cell [9].…”

Bone SPECT/CT in the Evaluation of Soft Tissue Calcifications in a Patient with Dermatomyositis

“…Corticosteroids and immunosuppressive agents are used in treatment. The excision of painful calcification areas may be required in some patients [1]. Whole body bone scintigraphy (WBBS) plays an important role in the detection of soft tissue calcification, planning and monitoring of treatment and disease activity [1,2].…”

“…The excision of painful calcification areas may be required in some patients [1]. Whole body bone scintigraphy (WBBS) plays an important role in the detection of soft tissue calcification, planning and monitoring of treatment and disease activity [1,2]. Correlation of anatomical and functional findings with Single Photon Emission Computed Tomography/ Computed Tomography (SPECT/ CT) is increased diagnostic accuracy of WBBS [3].…”