An Overview of Recent Advancements on Manganese-Based Nanostructures and Their Application for ROS-Mediated Tumor Therapy

Abstract

To date, cancer remains one of the most lethal diseases that threatens public safety. High concentrations of reactive oxygen species (ROS) can directly induce cell apoptosis and necrosis, so it is an effective strategy to increase the ROS content in tumor cells. In recent years, ROS-mediated cancer therapy has been extensively studied. As an important transition-metal element, Mn plays a key role in biological processes. With the rapid development of nanotechnology and oncology, Mn-based materials have been widely used in ROS-mediated cancer therapy as an ideal integrated nanoplatform. This review first summarizes the research progress of Mn-based nanomaterials (NMs), including their structures and main synthesis methods. Then the biomedical applications of Mn-based NMs for ROS-mediated cancer therapy are brought into focus. Finally, the challenges and development directions of Mn-based NMs used for ROS-mediated cancer therapy are rationally analyzed, which are necessary for their future clinical translation.

Manganese-based nanomaterials in diagnostics and chemodynamic therapy of cancers: new development

“…ROS denotes substances with high oxidative potential featuring oxygen radicals, encompassing peroxides, superoxides, singlet oxygen, and hydroxyl radicals among others. 26,28,29 Within organisms, ROS serve as crucial cellular signaling molecules, playing a key role in the regulation of diverse physiological processes and the maintenance of the cells' normal redox equilibrium. The generation of endogenous ROS primarily originates from the aerobic metabolism in cellular mitochondria.…”

Synthesis of Mn2O3 Nanoparticles and Determination of Its Inhibition Effect On Sera of Iraqi Patients with Diabetes Mellitus Type-2 and Diabetes Nephropathy

“…For example, α-MnO2nano-rods are more effective than β-MnO2nano spheres in inhibiting arginase in vitro [13]. The mechanism of arginase inhibition by manganese oxide Nanoparticles may involve the interaction of metal ions with the active site of the enzyme or the generation of reactive oxygen species (ROS) and reactive nitrogen species that can damage the enzyme [14].…”

“…Figure1. Manganese Nanostructures and Their therapeutic Application [14] However, Manganese oxide NPs may also cause oxidative stress, cytotoxicity, and gene-toxicity to Arginine-containing cells or tissues by generating (ROS)reactive oxygen species or disrupting the cellular redox balance. This can lead to cell death, DNA damage, or inflammation [14].…”

“…Manganese Nanostructures and Their therapeutic Application [14] However, Manganese oxide NPs may also cause oxidative stress, cytotoxicity, and gene-toxicity to Arginine-containing cells or tissues by generating (ROS)reactive oxygen species or disrupting the cellular redox balance. This can lead to cell death, DNA damage, or inflammation [14]. Disadvantages of Manganese nanoparticles such as decrease in the blood circulation time and accumulation in the brain, resulting in changes in the central nervous system followed by cognitive and movement abnormalities [20].…”

Boosting the sonodynamic performance of CoBiMn-layered double hydroxide nanoparticles via tumor microenvironment regulation for ultrasound imaging-guided sonodynamic therapy

“…It is well known that Mn 4+ can catalyze the reaction of H 2 O 2 to produce O 2 in an acidic environment, and also has oxidation activity to consume GSH [33][34][35]. Herein, we report the design of amorphous CoBiMn-LDH (a-CoBiMn-LDH) nanoparticles via an acid etching strategy, and explore these as a multifunctional sonosensitizer for US imaging-guided SDT (Fig.…”