An overview of recent advancements in small molecules suppression of oncogenic signaling of K-RAS: an updated review

Sabt, Ahmed; Tawfik, Haytham O.; Khaleel, Eman F.; Badi, Rehab Mustafa; Ibrahim, Hoda Atef Abdelsattar; Elkaeed, Eslam B.; Eldehna, Wagdy M.

doi:10.1007/s11030-023-10777-6

Cited by 3 publications

(1 citation statement)

References 188 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effect of such inhibitors in the developing and mature retina has not been studied, and may provide key insights into the function of prenylated proteins in retinal development and/or retinal pathologies. Post-prenylation enzymes RCE1P, STE24, and ICMT inhibitors have also been of interest as cancer therapeutic strategies ( 58 ), but their effects on the retinal structure and function remains to be investigated. Conditional gene deletion strategies or small molecule inhibitor studies are necessary to further elucidate the role and requirement of FTase, GGTase-I, FPPS, GGPPS, and post-prenylation processing enzymes in the maintenance of normal retinal structure and function.…”

Section: Protein Prenylation In the Neural Retinamentioning

confidence: 99%

Updates on protein-prenylation and associated inherited retinopathies

Ashok,

Ramachandra Rao

2024

Front. Ophthalmol.

View full text Add to dashboard Cite

Membrane-anchored proteins play critical roles in cell signaling, cellular architecture, and membrane biology. Hydrophilic proteins are post-translationally modified by a diverse range of lipid molecules such as phospholipids, glycosylphosphatidylinositol, and isoprenes, which allows their partition and anchorage to the cell membrane. In this review article, we discuss the biochemical basis of isoprenoid synthesis, the mechanisms of isoprene conjugation to proteins, and the functions of prenylated proteins in the neural retina. Recent discovery of novel prenyltransferases, prenylated protein chaperones, non-canonical prenylation-target motifs, and reversible prenylation is expected to increase the number of inherited systemic and blinding diseases with aberrant protein prenylation. Recent important investigations have also demonstrated the role of several unexpected regulators (such as protein charge, sequence/protein-chaperone interaction, light exposure history) in the photoreceptor trafficking of prenylated proteins. Technical advances in the investigation of the prenylated proteome and its application in vision research are discussed. Clinical updates and technical insights into known and putative prenylation-associated retinopathies are provided herein. Characterization of non-canonical prenylation mechanisms in the retina and retina-specific prenylated proteome is fundamental to the understanding of the pathogenesis of protein prenylation-associated inherited blinding disorders.

show abstract

Section: Protein Prenylation In the Neural Retinamentioning

confidence: 99%