An overview of synthetic strategies and current applications of gold nanorods in cancer treatment

Lakhani, Prit; Rompicharla, Sri Vishnu Kiran; Ghosh, Balaram; Biswas, Swati

doi:10.1088/0957-4484/26/43/432001

Cited by 25 publications

(11 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Originating from the so‐called localized surface plasmonic resonance, the optical features of plasmonic NPs were shown to be correlated with their size and shape . As a consequence, tunable size nanospheres, nanorods, nanostars, nanoflowers, etc, were elaborated and used in a variety of biochemical and biomedical purposes . Among the widespread localized surface plasmonic resonance ‐based methodologies, surface‐enhanced Raman scattering (SERS), using or not functionalized particles, has been recognized as an ultra‐trace detection tool in biomedicine …”

Section: Introductionmentioning

confidence: 99%

Large size citrate‐reduced gold colloids appear as optimal SERS substrates for cationic peptides

López-Tobar

Hernández

Chenal

et al. 2016

J Raman Spectroscopy

View full text Add to dashboard Cite

Surface‐enhanced Raman spectra of two cyclic cationic peptides with therapeutic interest, somatostatin‐14 and its synthetic analog octreotide, were simultaneously analyzed as a function of concentration and colloidal size. It appeared that the large size (~95 nm) citrate‐reduced gold nanoparticles are the most adequate substrates for providing an optimal Raman signal enhancement within the 10−6–10−7 m peptide concentration range. It could also be evidenced that these large size particles can give rise to such a remarkable result within the first month following their elaboration. In fact, the recorded Raman spectra after this period mainly originate from the molecular species in the coverage of gold particles and not from the adsorbed peptides. To bring clarification to the temporal evolution of gold colloids, a systematic analysis was performed during 3 months on different particle sizes in the 15–150 nm range. The data obtained by a combined use of different techniques (Ultraviolet‐visible absorption, z‐potential, transmission electron microscopy, and Raman scattering) are consistent with a permanent evolution of the colloidal coverage, assignable to the gradual transformation of citrate anions and their substitution by oxidized products. It can be concluded that only small and medium size nanoparticles (≤ 40 nm) are able to regenerate their initial features after the first month, while large size colloids are subjected to a continuous degradation of their plasmonic and electrostatic properties. Copyright © 2016 John Wiley & Sons, Ltd.

show abstract

Section: Introductionmentioning

confidence: 99%

Large size citrate‐reduced gold colloids appear as optimal SERS substrates for cationic peptides

López-Tobar

Hernández

Chenal

et al. 2016

J Raman Spectroscopy

View full text Add to dashboard Cite

show abstract

“…Other forms were later obtained, such as nanorods, nanoshells, and nanocages. [94][95][96] Polymer NPs. Other types of NPs can be generated from a wide range of polymers, including natural and synthetic substances that are composed of macromolecules, such as poly(lactide-coglycolide), poly(lactic acid), poly(e-caprolactone), chitosan, and poly(alkyl cyanoacrylates).…”

Section: Nanoparticlesmentioning

confidence: 99%

Nanobiomaterials’ applications in neurodegenerative diseases

et al. 2016

View full text Add to dashboard Cite

The blood-brain barrier is the interface between the blood and brain, impeding the passage of most circulating cells and molecules, protecting the latter from foreign substances, and maintaining central nervous system homeostasis. However, its restrictive nature constitutes an obstacle, preventing therapeutic drugs from entering the brain. Usually, a large systemic dose is required to achieve pharmacological therapeutic levels in the brain, leading to adverse effects in the body. As a consequence, various strategies are being developed to enhance the amount and concentration of therapeutic compounds in the brain. One such tool is nanotechnology, in which nanostructures that are 1-100 nm are designed to deliver drugs to the brain. In this review, we examine many nanotechnology-based approaches to the treatment of neurodegenerative diseases. The review begins with a brief history of nanotechnology, followed by a discussion of its definition, the properties of most reported nanomaterials, their biocompatibility, the mechanisms of cell-material interactions, and the current status of nanotechnology in treating Alzheimer's, Parkinson's diseases, and amyotrophic lateral sclerosis. Of all strategies to deliver drug to the brain that are used in nanotechnology, drug release systems are the most frequently reported.

show abstract

“…Gold nanorods (NRs) are rod-shaped gold nanoparticles with the characteristics of biocompatibility, surface plasmon resonance, and high photothermal efficiency [6], leading to the major applications of gold NRs in photoacoustic imaging, drug delivery and photothermal therapy of cancer cells [7,8]. Gold NRs exhibit two surface plasmon bands.…”

Section: Introductionmentioning

confidence: 99%

A Prospective Study of Laser Treatment of Port Wine Stain Associated with Gold Nanorods

Chen¹

2017

JNMR

View full text Add to dashboard Cite

Laser therapy based on the selective photothermolysis has been regarded as the most effective treatment strategy for Port-Wine Stain (PWS) caused by the expansion of dermal capillaries. A long-pulsed Neodymium: Yttrium Aluminum Garnet (Nd:YAG) laser has great potential for deeply situated PWS. However, the weak absorption of blood to Nd:YAG laser limits the laser treatment efficacy. Gold nanorods, which can convert the absorbed near-infrared light into localized heat, have shown potential for photo-activated cancer therapy. Owing to their unique surface plasmon resonance and photothermal conversion effect, gold nanorods may be one of possible strategies for improving laser treatment efficacy of PWS by enhancing blood absorption to Nd:YAG laser. In this study, an experimental study was carried out to compare laser-induced thermal response of blood vessels in vivo animal model before and after injection of gold nanorods. The results demonstrated that the obvious thermal response of blood vessels to Nd:YAG can be obtained with lower laser energy fluence and less pulse number under the assistance of gold NRs, suggesting that Nd:YAG laser treatment combined with gold NRs may be a novel treatment strategy for PWS.

show abstract

An overview of synthetic strategies and current applications of gold nanorods in cancer treatment

Cited by 25 publications

References 97 publications

Large size citrate‐reduced gold colloids appear as optimal SERS substrates for cationic peptides

Large size citrate‐reduced gold colloids appear as optimal SERS substrates for cationic peptides

Nanobiomaterials’ applications in neurodegenerative diseases

A Prospective Study of Laser Treatment of Port Wine Stain Associated with Gold Nanorods

Contact Info

Product

Resources

About