An Overview of the Application of Maqasid Al-Shariah into Cartilage Tissue Engineering

Radzi, Muhammad Aa'zamuddin Ahmad; Hashi, Abdurezak Abdulahi; Sha'ban, Munirah

doi:10.31436/imjm.v17i1.1013

Cited by 3 publications

(3 citation statements)

References 25 publications

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“…The degenerative joint disease, i.e. osteoarthritis, may cause harm in terms of disability, mortality, mental and economic instability, and affect sexual activity (12). ACTE, being one of the solutions in treating osteoarthritis, complements the currently available treatments in managing the disease.…”

Section: Resultsmentioning

confidence: 99%

“…The 'cell-scaffold' constructs will be implanted back into the same patient in the affected region of the articular cartilage. However, the ethical and legal concerns of such practices, including cell sources, biomaterials, signalling factors, and animal study, have yet to be addressed systematically (12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

“…Muslim academicians suggest that the authority should draft an Islamic ethical framework to govern the development of ACTE research, which may serve tissue engineering as a whole (12)(13)(14)(15). Thus, based on the discussion in the thesis, an Islamic ethico-legal framework was formulated as a comprehensive approach in educating the stakeholders of ACTE research.…”

Section: Introductionmentioning

confidence: 99%

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An Islamic Ethico-legal Framework for Articular Cartilage Tissue Engineering Research

Radzi¹,

Sha'ban²,

Azharuddin³

et al. 2022

MJMHS

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The available studies showed a connection between mental health features of anxiety, depression, and stress with osteoarthritic patients. The joint disease can be treated with articular cartilage tissue engineering (ACTE), which has undergone various research and development. However, the ethical and legal concerns of such practices, including cell sources, biomaterials, signalling factors, and animal study, have yet to be addressed systematically. The study aims to formulate an Islamic ethical and legal framework to facilitate both the scientific and social progress of ACTE research in the Malaysian context. The present work used content analysis of relevant journal articles obtained through systematic online searches. The study then utilised the existing documents on Malaysian laws, regulations, and guidelines; and fatwā related to the ACTE research to build a framework. Based on the documents, the ethical and legal framework was formulated. The framework was proposed to include six steps in handling the ethical and legal issues in ACTE research. There are (1) to select research design and strategy, (2) to identify the potential issues, (3) to review relevant laws, regulations and guidelines, (4) to review the relevant sharīʿah rulings and opinions, (5) to consider possible alternatives and its consequences, and (6) to decide and implement the best course of action. These six steps are aligned based on the concept of Maqāṣid al-Sharīʿah (the objectives of Islamic law) and al-Qawāʿid al-Fiqhiyyah (Islamic Legal Maxim). The framework can serve as a guide to conduct safe and sound ACTE research based on the Islamic perspective.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An Islamic Ethico-legal Framework for Articular Cartilage Tissue Engineering Research

Radzi¹,

Sha'ban²,

Azharuddin³

et al. 2022

MJMHS

Self Cite

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The Ethical Implications of Tissue Engineering for Regenerative Purposes: A Systematic Review

Kanter

Jongsma

Verhaar

et al. 2023

Tissue Engineering Part B: Reviews

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Tissue Engineering (TE) is a branch of Regenerative Medicine (RM) that combines stem cells and biomaterial scaffolds to create living tissue constructs to restore patients' organs after injury or disease. Over the last decade, emerging technologies such as 3D bioprinting, biofabrication, supramolecular materials, induced pluripotent stem cells, and organoids have entered the field. While this rapidly evolving field is expected to have great therapeutic potential, its development from bench to bedside presents several ethical and societal challenges. To make sure TE will reach its ultimate goal of improving patient welfare, these challenges should be mapped out and evaluated. Therefore, we performed a systematic review of the ethical implications of the development and application of TE for regenerative purposes, as mentioned in the academic literature. A search query in PubMed, Embase, Scopus, and PhilPapers yielded 2451 unique articles. After systematic screening, 237 relevant ethical and biomedical articles published between 2008 and 2021 were included in our review. We identified a broad range of ethical implications that could be categorized under 10 themes. Seven themes trace the development from bench to bedside: (1) animal experimentation, (2) handling human tissue, (3) informed consent, (4) therapeutic potential, (5) risk and safety, (6) clinical translation, and (7) societal impact. Three themes represent ethical safeguards relevant to all developmental phases: (8) scientific integrity, (9) regulation, and (10) patient and public involvement. This review reveals that since 2008 a significant body of literature has emerged on how to design clinical trials for TE in a responsible manner. However, several topics remain in need of more attention. These include the acceptability of alternative translational pathways outside clinical trials, soft impacts on society and questions of ownership over engineered tissues. Overall, this overview of the ethical and societal implications of the field will help promote responsible development of new interventions in TE and RM. It can also serve as a valuable resource and educational tool for scientists, engineers, and clinicians in the field by providing an overview of the ethical considerations relevant to their work. Impact statement To our knowledge, this is the first time that the ethical implications of Tissue Engineering (TE) have been reviewed systematically. By gathering existing scholarly work and identifying knowledge gaps, this review facilitates further research into the ethical and societal implications of TE and Regenerative Medicine (RM) and other emerging biomedical technologies. Moreover, it will serve as a valuable resource and educational tool for scientists, engineers, and clinicians in the field by providing an overview of the ethical considerations relevant to their work. As such, our review may promote successful and responsible development of new strategies in TE and RM.

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Takaful Protection for Mental Health Illness From the Perspective of Maqasid Shariah

Khairi¹,

Samat²,

Laili³

et al. 2020

IJFR

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Mental health illness becomes one of the major illnesses in Malaysia aside from heart disease. It was recently reported that 29.2% of Malaysians are suffering from mental health illness which increases threefold from the previous year. Majority of the Malaysians suffering from mental health illness comes from the lowest income group. This shows that the lowest income group has less opportunity to seek treatment due to the cost. Even though other countries have started to offer mental health insurance such as the United States of America, United Kingdom, Australia and recently Singapore, Malaysia is still way behind in offering coverage for mental health illness. Therefore, the objective of this paper is to study the mental health takaful from the perspective of Maqasid shariah. The results from this study show that mental health takaful is able to meet the requirement of Maqasid shariah and preserve the benefits of, and prevent harm to human wellbeing. Furthermore, this study will provide an insight to the takaful industry for developing new products that could help mental health disorder patients.

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An Overview of the Application of Maqasid Al-Shariah into Cartilage Tissue Engineering

Cited by 3 publications

References 25 publications

An Islamic Ethico-legal Framework for Articular Cartilage Tissue Engineering Research

An Islamic Ethico-legal Framework for Articular Cartilage Tissue Engineering Research

The Ethical Implications of Tissue Engineering for Regenerative Purposes: A Systematic Review

Takaful Protection for Mental Health Illness From the Perspective of Maqasid Shariah

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