An overview of the management of osteoporosis in the aging female population

Amin, Umara; McPartland, Aoife; O’Sullivan, Miriam; Silke, Charlotte

doi:10.1177/17455057231176655

Cited by 19 publications

(2 citation statements)

References 72 publications

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“…We suspect that many women whom physicians considered as trauma patients may have underlying low BMD. A history of prior fracture at any site for all ages is considered an important risk factor for future fractures [ 19 , 32 , 34 ], particularly a fracture before menopause [ 1 ]. Paying greater attention to all cases of fragility fractures in young women might lead to more timely interventions that can reduce later fracture risk.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy and lactation-associated osteoporosis as a major type of premenopausal osteoporosis: a retrospective cohort study based on real-world data

Kasahara,

Tanaka-Mizuno,

Tsuji

et al. 2024

BMC Pregnancy Childbirth

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Background Pregnancy and lactation-associated osteoporosis (PLO), as well as premenopausal osteoporosis, might be a predictor of future fracture. This study aimed to describe the clinical features of PLO as a subtype of premenopausal osteoporosis and to evaluate medical interventions for it. Methods From an administrative claims database including 4,224,246 people in Japan, we classified women for whom the date of childbirth had been defined and who had suffered low-trauma fracture between the ages of 18–47 years as the premenopausal osteoporosis group. A fracture site for which the odds ratio for fractures occurring between 5 months before and 12 months after childbirth (around childbirth) was greater than 1 was considered the PLO site. We classified patients with a fracture at the PLO site around childbirth as the PLO group. The control group consisted of 500 women without fragility fractures. We investigated some drugs and diseases to explore fracture-causing factors, as well as medical interventions such as osteoporosis diagnosis, bone densitometry, anti-osteoporosis pharmacotherapy, and lactation inhibitors. Results In total, 231 parous women were classified into the premenopausal osteoporosis group. The most common fracture was vertebral fracture and was likely to occur around childbirth, followed by distal radius and sacral fractures, which were rare around childbirth. Considering vertebral, pelvic, and proximal femoral fractures as PLO sites, 56 women with 57 PLO fractures were classified into the PLO group. The incidence of PLO was estimated at 460 per million deliveries. Ovulation disorder and high maternal age were associated with the development of PLO. Vertebral fracture was the most common PLO fracture. It was mainly diagnosed a few months, and possibly up to 1 year, postpartum. PLO patients with vertebral fractures underwent more medical interventions than did those with other fractures, but they were still inadequate. Conclusions PLO with vertebral fracture was one of the major types of premenopausal osteoporosis. The prevalence of PLO is considered to be higher than previously thought, indicating the presence of potentially overlooked patients. More timely interventions for PLO might lead to the improved management of latent patients with premenopausal osteoporosis and reduce future fracture risk.

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Section: Discussionmentioning

confidence: 99%

Pregnancy and lactation-associated osteoporosis as a major type of premenopausal osteoporosis: a retrospective cohort study based on real-world data

Kasahara,

Tanaka-Mizuno,

Tsuji

et al. 2024

BMC Pregnancy Childbirth

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“…This physiological environment induces trabecular thinning, a disruption of connectivity in the trabecular regions, cortical thinning, and increased cortical porosity. Given these hormonal shifts and the slower rate of change in serum sex hormone levels in males, which does not result in a concurrent rise in bone remodeling, female patients exhibit a higher incidence of bone fragility [33].…”

Section: Btms In Critical Illnessmentioning

confidence: 99%

Pathophysiology and Therapeutic Management of Bone Loss in Patients with Critical Illness

Kim,

Kim

2023

Pharmaceuticals

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Patients with critical illnesses are at higher risk of comorbidities, which can include bone mineral density loss, bone turnover marker increase, and fragility fractures. Patients admitted to intensive care units (ICUs) have a higher risk of bone fractures. Since hypermetabolism is a characteristic of ICU patients, such patients are often rapidly affected by systemic deterioration, which often results in systemic wasting disease. Major risk factors for ICU-related bone loss include physical restraint, inflammation, neuroendocrine stress, malnutrition, and medications. A medical history of critical illness should be acknowledged as a risk factor for impaired bone metabolism. Bone loss associated with ICU admission should be recognized as a key component of post-intensive care syndrome, and further research that focuses on treatment protocols and prevention strategies is required. Studies aimed at maintaining gut integrity have emphasized protein administration and nutrition, while research is ongoing to evaluate the therapeutic benefits of anti-resorptive agents and physical therapy. This review examines both current and innovative clinical strategies that are used for identifying risk factors of bone loss. It provides an overview of perioperative outcomes and discusses the emerging novel treatment modalities. Furthermore, the review presents future directions in the treatment of ICU-related bone loss.

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Association of Vitamin B12 with Bone Mineral Density

Jani,

Patel

2024

Advances in Biochemistry in Health and Disease

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An overview of the management of osteoporosis in the aging female population

Cited by 19 publications

References 72 publications

Pregnancy and lactation-associated osteoporosis as a major type of premenopausal osteoporosis: a retrospective cohort study based on real-world data

Pregnancy and lactation-associated osteoporosis as a major type of premenopausal osteoporosis: a retrospective cohort study based on real-world data

Pathophysiology and Therapeutic Management of Bone Loss in Patients with Critical Illness

Association of Vitamin B12 with Bone Mineral Density

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