2020
DOI: 10.1016/j.ejphar.2020.173457
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An overview of the pathogenic mechanisms involved in severe cases of COVID-19 infection, and the proposal of salicyl-carnosine as a potential drug for its treatment

Abstract: Multiple organ failure in COVID-19 patients is a serious problem which can result in a fatal outcome. Damage to organs and tissues, including general lung dysfunction, develops as a consequence of ischemia, which, in turn, is caused by thrombosis in small blood vessels and hypoxia, leading to oxidative stress and inflammation. Currently, research is underway to screen existing drugs for antioxidant, antiplatelet and anti-inflammatory properties. Having studied the available publications concerning the mechanis… Show more

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Cited by 19 publications
(16 citation statements)
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“…As a result, the unprecedented scale and severity of such a pandemic have aroused increasing interest in various research domains. First, attention was focused in particular on understanding this virus’ pathogenic mechanism [ 3 , 4 ], clinical characteristics and transmission route [ 5 ], as its presence has posed significant challenges to global safety in public health. Compared to SARS, COVID-19 is much more infectious.…”
Section: Introductionmentioning
confidence: 99%
“…As a result, the unprecedented scale and severity of such a pandemic have aroused increasing interest in various research domains. First, attention was focused in particular on understanding this virus’ pathogenic mechanism [ 3 , 4 ], clinical characteristics and transmission route [ 5 ], as its presence has posed significant challenges to global safety in public health. Compared to SARS, COVID-19 is much more infectious.…”
Section: Introductionmentioning
confidence: 99%
“…The unexpected onset of the global health crisis caused many scholars to change their research domains towards pandemic-related areas. A significant number of studies have already been conducted in terms of the medical aspects of the coronavirus-2019, including the understanding of coronavirus-2019 pathogenic mechanism [ 1 ], its transmission routes [ 2 ], and different patterns of symptom development [ 3 , 4 , 5 , 6 ]. Several researchers have already identified obesity; ageing; and comorbidities such as cardiovascular diseases, cancers, and diabetes as risk factors in SARS-CoV-19 patients [ 7 , 8 , 9 , 10 ].…”
Section: Introductionmentioning
confidence: 99%
“…Recently, Kulikova and colleagues (23) developed an analogue of carnosine, salicyl-carnosine, designed to circumvent the rapid degradation by serum carosinase. Salicyl-carnosine effectively mitigates the three prominent pathogenic hallmarks of COVID-19—oxidative stress, thrombosis, and inflammation—and has been proposed as a promising means to treat severe cases of COVID-19 (24).…”
Section: Discussionmentioning
confidence: 99%