An Overview of Treatments for Obesity in a Population with Mental Illness

Taylor, Valerie H.; Stonehocker, Brian; Steele, Margot; Sharma, Arya M.

doi:10.1177/070674371205700104

Cited by 17 publications

(11 citation statements)

References 89 publications

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“…MetS, obesity and diabetes have become worldwide epidemics that affect patients of all ages and result in high health care costs [75]. Our results indicate that fructose induced MetS affects specific aspects of neuronal and synaptic plasticity, and raises concerns about the risk imposed of MetS for the pathogenesis of disorders affecting cognitive abilities such as AD [11] and depression/anxiety [76].…”

Section: Discussionmentioning

confidence: 96%

Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance

Cisternas

Salazar

Serrano

et al. 2015

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Metabolic syndrome (MetS) is a global epidemic, which involves a spectrum of metabolic disorders comprising diabetes and obesity. The impact of MetS on the brain is becoming to be a concern, however, the poor understanding of mechanisms involved has limited the development of therapeutic strategies. We induced a MetS-like condition by exposing mice to fructose feeding for 7 weeks. There was a dramatic deterioration in the capacity of the hippocampus to sustain synaptic plasticity in the forms of long-term potentiation (LTP) and long-term depression (LTD). Mice exposed to fructose showed a reduction in the number of contact zones and the size of postsynaptic densities (PSDs) in the hippocampus, as well as a decrease in hippocampal neurogenesis. There was an increase in lipid peroxidation likely associated with a deficiency in plasma membrane excitability. Consistent with an overall hippocampal dysfunction, there was a subsequent decrease in hippocampal dependent learning and memory performance, i.e., spatial learning and episodic memory. Most of the pathological sequel of MetS in the brain was reversed three month after discontinue fructose feeding. These results are novel to show that MetS triggers a cascade of molecular events, which disrupt hippocampal functional plasticity, and specific aspects of learning and memory function. The overall information raises concerns about the risk imposed by excessive fructose consumption on the pathology of neurological disorders.

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Section: Discussionmentioning

confidence: 96%

Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance

Cisternas

Salazar

Serrano

et al. 2015

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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“…Studies estimate that roughly 30%-50% of people incarcerated in Canada suffer from some form of mental illness (Farrell MacDonald et al, 2015;Vacheret & Lafortune, 2011). Moreover, mental illness and psychotropic medication use are known contributors to weight gain and obesity because they both affect metabolism and food intake (Dent et al, 2012;Taylor et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Weight Gain and Mental Health in the Canadian Prison Population

Johnson

Chaput

Blanchard

et al. 2021

Journal of Correctional Health Care

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Most inmates gain excessive bodyweight during incarceration in Canadian federal penitentiaries. It is currently unknown if the weight gain is related to participants' higher prevalence of mental illness and/or psychotropic medication use. This study examined how weight change (kg) and body mass index (BMI) change (kg/m 2 ) of 1,420 participants were associated with mental health status and psychotropic medication use. Participants who took psychotropic medications did not gain more weight during incarceration compared to their counterparts who were not taking psychotropic medications (6.5 kg vs. 6.0 kg, p = 0.87, respectively). However, participants taking psychotropic medications were more likely to be overweight or obese, which means they already had higher BMI at the beginning of their incarceration as opposed to gaining more weight during incarceration. Weight gain of participants observed during incarceration in Canadian federal penitentiaries was not related to the higher prevalence of mental illness or psychotropic medication use.

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“…Reconhecida como o método de terapia para tratar problemas psicológicos mais pesquisados para o tratamento do TCAP, a terapia cognitivo-comportamental tem sido amplamente abordada em vários locais especializados em transtornos mentais [33][34][35][36][37][38] e se fundamenta na hipótese de que um complexo distúrbio de princípios está relacionado à manifestação e permanência do TCAP. Em virtude disto, os cernes do tratamento são a alteração de padrões distorcidos de pensamentos e a reestruturação de crenças supervalorizadas relacionadas ao peso e à imagem do corpo, sendo abordadas diversas técnicas cognitivas com esse intuito.…”

Section: Resultados E Discussão O Obesidade No Brasil E No Mundounclassified

Intervenção psicológica em adultos obesos com o transtorno da compulsão alimentar periódica (TCAP)

Marçal¹,

Júnior²

2018

Arch Health Invest

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ResumoA obesidade é considerada, tanto em países em desenvolvimento quanto em países desenvolvidos, um importante problema de saúde pública,e, de acordo com a Organização Mundial da Saúde (OMS), há mais de um bilhão de adultos com excesso de peso e pelo menos trezentos milhões são obesos.Associado à obesidade existe o transtorno da compulsão alimentar, o qual é caracterizado por um distúrbio persistente da alimentação ou comportamento relacionado com a alimentação, resultando em alterações no consumo ou na absorção do alimento. O presente estudo se propôs a identificar na literatura os principais aspectos do diagnóstico dos pacientes acometidos pelo transtorno da compulsão alimentar periódica (TCAP), apontar os impactos que este transtorno pode ter na qualidade emocional e de vida, bem como enfatizar a importância da terapia cognitivo-comportamental (TCC) como forma de tratamento para estes pacientes. Foram pesquisados nas bases de dados: SciELO (Scientific Electronic Library Online), CAPES, Embase, PubMed (National Library ofMedicine), MEDLINE e DECS artigos que tratassem da obesidade, do transtorno da compulsão alimentar em adultos e da terapia Cognitivo-Comportamental. Observou-se que o transtorno da compulsão alimentar periódica deve ser tratado como uma categoria distinta de transtorno alimentar, conforme o Diagnostic and Statistical Manual of Mental Disorders, atualmente em sua quinta edição, e a terapia cognitiva comportamental vem mostrando eficácia, proporcionando uma redução significativa da compulsão alimentar na maioria dos pacientes. Descritores: Obesidade; Transtorno da Compulsão Alimentar; Terapia Cognitiva. AbstractObesity is considered a major public health problem in both developing and developed countries and, according to the World Health Organization (WHO), there are over one billion overweight and at least three hundred million are obese. Associated with obesity there is binge eating disorder, which is characterized by a persistent eating disorder or related eating behavior, resulting in changes in food intake or absorption. The present study aimed to identify in the literature the main aspects of the diagnosis of patients with periodic binge eating disorder (BED), to point out the impacts that this disorder may have on emotional and life quality, as well as to emphasize the importance of cognitive therapy (CBT) as a form of treatment for these patients. We searched the databases (ScientificElectronic Library Online), CAPES, Embase, PubMed (National Library of Medicine), MEDLINE and DECS articles dealing with obesity, binge eating disorder in adults and Cognitive-Behavioral therapy. It was observed that periodic binge eating disorder should be treated as a distinct category of eating disorder, according to the Diagnostic and Statistical Manual of Mental Disorders, currently in its fifth edition, and cognitive behavioral therapy has shown efficacy, providing a significant reduction of binge eating in most patients. Descriptors: Obesity; Binge-Eating Disorder; Cognitive Therapy. ResumenLa obes...

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An Overview of Treatments for Obesity in a Population with Mental Illness

Cited by 17 publications

References 89 publications

Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance

Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance

Weight Gain and Mental Health in the Canadian Prison Population

Intervenção psicológica em adultos obesos com o transtorno da compulsão alimentar periódica (TCAP)

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