An overview on floating microsphere: Gastro Retention Floating drug delivery system (FDDS)

Hafeez, Abdul; Maurya, Arun; Singh, J. P.; Mittal, Ankit; Rana, Lakhan

doi:10.31254/phyto.2013.21310

Cited by 9 publications

(4 citation statements)

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“…e.g. (Dioctyl sulphosuccinate, Sodium lauryl sulphate), Pluronic F127 & F68, bile salts (Sodium taurocholate & deoxycholate), Calcium thioglycolate, urea, soyabean casein, etc [67,69].…”

Section: Surfactantsmentioning

confidence: 99%

Anti-Neoplastic Transdermal Patches: A Novel Approach for Targeted Drug Delivery Using Nanocarriers in Cancer Therapy

Jha

Sahu

Arora

2022

JASR

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Innovative Nano-carrier-based transdermal patches, a wonder of advanced technologies, have received overwhelming endorsement in medicinal applications primarily in the provision of anti-neoplastic drugs. The purpose of this study was to review the limitations of conventional therapeutic initiatives namely chemotherapy, having several adverse effects, including significant inflammation, toxicity, and discomfort. Antineoplastic transdermal patches can be used as a prophylactic treatment method to treat a variety of cancers through the skin. Novel transdermal methods and Nanocarrier formulations have evolved to resolve the skin constraints and delivering the active drug to the underlying tissue of the skin enabling access to the systemic absorption of drugs and eventually get within tumour cells by approaching different targeting mechanisms. The transdermal administration of antineoplastic drugs is a promising alternative for boosting site-specific application, minimizing adverse effects, hepatic first-pass metabolism and promoting therapeutic value. Furthermore, the utilization of nanocarriers serves as a permeation enhancer to broaden the spectrum of medicines accessible for transdermal administration that has emerged as a viable and intriguing option. This review examines the benefits of transdermal delivery for anti-neoplastic drugs to ensure a good insight into their effectiveness in terms of modern clinical demands, to present a highlighted overview of transdermal drug delivery, and seeks to better comprehend the nano-formulations employed in transdermal drug delivery system (TDDS). Conclusively, reflecting the framework for future research and promoting the chemotherapeutic use of transdermal delivery over conventional dosage forms.

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“…e.g. (Dioctyl sulphosuccinate, Sodium lauryl sulphate), Pluronic F127 & F68, bile salts (Sodium taurocholate & deoxycholate), Calcium thioglycolate, urea, soyabean casein, etc [67,69].…”

Section: Surfactantsmentioning

confidence: 99%

Anti-Neoplastic Transdermal Patches: A Novel Approach for Targeted Drug Delivery Using Nanocarriers in Cancer Therapy

Jha

Sahu

Arora

2022

JASR

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“…Transfersomes carriers create a drug deposition in the systemic circulation that is having a high concentration of the drug. Transfersomes contain a component that can decrease the stability of lipid bilayers and thus leading to deformable vesicles 33 . 12.4.2.…”

Section: Electro-osmosismentioning

confidence: 99%

Untitled

2022

IJPSR

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Currently, oral drug delivery and parenteral drug delivery are used for the treatment of various diseases. In the oral drug delivery system, due to the first-pass metabolism and acidic environment of the gastrointestinal route, the drug exposes to acids and enzymes present in the gastrointestinal tract, which may lead to degradation of the compound, which ultimately results in poor bioavailability of the molecule. On the other hand, the parenteral drug delivery system has its own disadvantages as it is invasive and needs skilled personnel for administration. To overcome these problems, the transdermal drug delivery system is introduced as a novel approach, and recently there is tremendous interest in transdermal drug delivery systems. A transdermal patch is a medicated adhesive patch winch that is placed onto the skin to deliver the appropriate dose of the drug through the skin and directly into the bloodstream. In this, transdermal patches are prepared for drug penetration through the skin layer (Stratum corneum barrier). To avoid the stratum corneum barrier, the microneedle-based transdermal drug delivery system is advantageous. Microneedles are classified into solid microneedles, coated microneedles, dissolving microneedles, hollow microneedles, and hydrogel-forming microneedles. This review provides information regarding transdermal drug delivery, a factor that can affect the transdermal delivery, ingredients used in the formulation of TDDS, drug penetration, different types of methods for formulations, and some advanced techniques such as microneedles. INTRODUCTION:Recently, there is growing interest in the novel drug delivery system for existing drug molecules. The novel drug delivery system offers to increased safety and efficiency of a drug molecule and also improves patient compliance. Transdermal drug delivery systems (TDDS) are self-contained and discrete dosage forms. Another advantage of the TDDS is that the dose is reduced as compared to the oral route of drug delivery 1 .

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“…One of the challenges encountered involves effectively localizing the dosage form within the intended section of the gastrointestinal tract. Addressing this physiological hurdle has prompted exploration into numerous drug delivery systems designed to extend the duration of gastric retention (GRT) [2].…”

Section: Introductionmentioning

confidence: 99%

Advances in the Preparation Techniques of Floating Microspheres with Exploration of AI Tool in Product Development

2023

PDRAJ

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This review paper focuses on recent developments in gastroretentive drug delivery systems for controlled release oral drug administration. Gastric emptying’s variability presents challenges to drug delivery systems, making gastroretentive drug delivery systems increasingly popular for retaining drugs in the stomach and ensuring gradual release. Traditional oral delivery systems often fail to overcome gastrointestinal obstacles, resulting in incomplete drug release, decreased efficacy. Thus, achieving prolonged gastric residence times is crucial, particularly for drugs with upper small intestine absorption windows. Gastro retentive drug delivery system provide for prolonged drug release in the upper digestive system, improving bioavailability for drugs with narrow therapeutic windows, extending dosing intervals, and enhancing patient compliance. The purpose of this review is to discuss recent advancements in the preparation techniques for floating drug delivery systems and highlights the incorporation of AI-Enabled design and optimization in drug release behavior. These technologies enhance precision and efficiency in gastroretentive drug delivery systems development, promising further improvements in drug delivery effectiveness and patient adherence.

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An overview on floating microsphere: Gastro Retention Floating drug delivery system (FDDS)

Cited by 9 publications

References 0 publications

Anti-Neoplastic Transdermal Patches: A Novel Approach for Targeted Drug Delivery Using Nanocarriers in Cancer Therapy

Anti-Neoplastic Transdermal Patches: A Novel Approach for Targeted Drug Delivery Using Nanocarriers in Cancer Therapy

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Advances in the Preparation Techniques of Floating Microspheres with Exploration of AI Tool in Product Development

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