An Overview on Gold Nanorods as Versatile Nanoparticles in Cancer Therapy

Nejabat, Masoud; Samie, Ali; Ramezani, Mohammad; Alibolandi, Mona; Abnous, Khalil; Taghdisi, Seyed Mohammad

doi:10.1016/j.jconrel.2023.01.009

Cited by 63 publications

(22 citation statements)

References 159 publications

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“…Currently, the combination of CT, PDT, and PTT is creating more attention because of the outstanding sustainable drug release, improved tumor ablation, and low cytotoxicity [ 168 ]. The remarkable therapeutic abilities of synergetic PDT-PTT, [ 173 , 174 , 175 ] CT-PDT, [ 176 , 177 ] and CT-PTT [ 178 , 179 ] are also established. Even though several double-modality therapy nanocarriers have been extensively well-organized, the nanostructure-dependent synergetic triple-modality PDT/PTT/CT therapy remains in the beginning stage.…”

Section: Synergetic Phototherapies Based On Gold Nanostructuresmentioning

confidence: 99%

Recent Progress of Gold-Based Nanostructures towards Future Emblem of Photo-Triggered Cancer Theranostics: A Special Focus on Combinatorial Phototherapies

Sekar¹,

Basavegowda

Thathapudi

et al. 2023

Pharmaceutics

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Cancer is one of the most dangerous health problems in the millennium and it is the third foremost human cause of death in the universe. Traditional cancer treatments face several disadvantages and cannot often afford adequate outcomes. It has been exhibited that the outcome of several therapies can be improved when associated with nanostructures. In addition, a modern tendency is being developed in cancer therapy to convert single-modal into multi-modal therapies with the help of existing various nanostructures. Among them, gold is the most successful nanostructure for biomedical applications due to its flexibility in preparation, stabilization, surface modifications, less cytotoxicity, and ease of bio-detection. In the past few decades, gold-based nanomaterials rule cancer treatment applications, currently, gold nanostructures were the leading nanomaterials for synergetic cancer therapies. In this review article, the synthesis, stabilization, and optical properties of gold nanostructures have been discussed. Then, the surface modifications and targeting mechanisms of gold nanomaterials will be described. Recent signs of progress in the application of gold nanomaterials for synergetic cancer therapies such as photodynamic and photo-thermal therapies in combination with other common interventions such as radiotherapy, chemotherapy, and will be reviewed. Also, a summary of the pharmacokinetics of gold nanostructures will be delivered. Finally, the challenges and outlooks of the gold nanostructures in the clinics for applications in cancer treatments are debated.

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Section: Synergetic Phototherapies Based On Gold Nanostructuresmentioning

confidence: 99%

Recent Progress of Gold-Based Nanostructures towards Future Emblem of Photo-Triggered Cancer Theranostics: A Special Focus on Combinatorial Phototherapies

Sekar¹,

Basavegowda

Thathapudi

et al. 2023

Pharmaceutics

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“…For UV−vis measurements, the free DOX, DOX-1, and DOX-3 NP solutions were placed in a dialysis bag (MWCO 6000−8000 Da) and dialyzed against acetate buffer (pH = 5.0), PBS (pH = 7.4) and 10% FBS-containing DMEM at a temperature of (37 ± 0.5) °C. At predetermined time intervals (2,4,6,8, and 24 h), 0.8 mL of the release medium was withdrawn and replaced with an equal volume of fresh release medium to maintain sink conditions. The absorption of DOX was measured at 479 nm for acetate buffer and PBS, and 497 nm was used to measure the absorption of DOX in DMEM.…”

Section: Drug Loading Andmentioning

confidence: 99%

“…Inorganic nanoplatforms possess a number of unique properties that demonstrate their potential in drug delivery applications. Examples of these features include the magnetic properties of iron oxide nanoparticles (IONPs), as well as the imaging, photophysical, or thermal properties of gold NPs (Au NPs), quantum dots, and upconverting NPs (UCNPs) . However, their low dispersibility in aqueous solutions and consequently short circulation half-life in the bloodstream limit the applicability of these NPs in biomedical applications such as drug delivery .…”

Section: Introductionmentioning

confidence: 99%

Exploring the Effect of Drug Loading on the Biological Fate of Polymer-Coated Solid Nanoparticles

et al. 2023

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Polymer-coated inorganic nanoparticles (NPs) have attracted great attention in drug delivery fields due to their unique magnetic, optical, and thermal properties. Recent studies have shown that the surface physicochemical properties of these NPs, including the size, shape, shell hydration, protein corona, and so forth, affect their biological fate. However, there has been less attention on the effect of the drug loading amount on the biological activity of inorganic NPs. Here, we used upconverting NPs (UCNPs) as an inorganic nanocarrier model, coated them with a triblock terpolymer poly(poly(ethylene glycol) methyl ether methacrylate)-block-polymethacrylic acid-block-ethylene glycol methacrylate phosphate (PPEGMEMA-b-PMAA-b-PEGMP), and loaded them with different amounts of anticancer drug doxorubicin (DOX) by electrostatic interactions. Our results show that the UCNPs with the lowest DOX loading amount (1.32%) have the best biological behavior. We find that the effect of DOX loading on the biological behavior of UCNPs is dominated by polymer shell hydration and the protein corona. The lowest drug-loading UCNPs are more hydrated and have more albumin coronas around, which leads to an increasing effect on the association with cancer cells and drug accumulation in the mouse tumor area. Our findings highlight the importance of optimizing the drug loading amounts in polymer-coated inorganic drug delivery systems as the amount and type of drug will alter the physical properties of the polymer shell.

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“…Numerous studies have used metallic elements or compounds for cancer treatment. They are neither essential elements but noble metals to have no cytotoxicity nor are chemically active in the metabolism, [17][18][19][20][21][22] such as Au nanoparticles (NPs). Essential metal-ion-based nanomaterials can also function as anticancer nanomedicine therapy alone without being in ion form, such as modified Fe 3 O 4 NPs with magnetic-thermal conversion ability.…”

Section: Doi: 101002/anbr202300069mentioning

confidence: 99%

A Brief Review on Manipulation of Essential Metal Ions as Nanomedicine for Cancer Therapy

Weng,

Chen

2023

Advanced NanoBiomed Research

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In this review, the latest progress in essential metal‐ion‐based nanomedicines for tumor therapy is summarized, existing challenges are addressed, and possible directions are proposed for such therapeutic strategies. Essential metal ions are critical for the metabolic activity of organisms. Their abnormal spatial and temporal distribution in biological systems, particularly inside the cell, disrupts biochemical processes and leads to irreversible physicochemical damage to cells. Thus, they can function as the foundation of targeted cancer therapies for tumor inhibition and eradication. Over the last decade, numerous essential metal‐ion‐based cancer therapies have been developed to fight a wide spectrum of cancers with improved efficiency and minor drug resistance. Triggering biocatalysis, affecting protein metabolism, interfering with signal transduction, damaging DNA, and initiating biomineralization are the main mechanisms underlying these therapies. In this study, it is aimed to provide readers with general implications for future research for an increased interest in future clinical applications of these advanced cancer therapies.

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An Overview on Gold Nanorods as Versatile Nanoparticles in Cancer Therapy

Cited by 63 publications

References 159 publications

Recent Progress of Gold-Based Nanostructures towards Future Emblem of Photo-Triggered Cancer Theranostics: A Special Focus on Combinatorial Phototherapies

Recent Progress of Gold-Based Nanostructures towards Future Emblem of Photo-Triggered Cancer Theranostics: A Special Focus on Combinatorial Phototherapies

Exploring the Effect of Drug Loading on the Biological Fate of Polymer-Coated Solid Nanoparticles

A Brief Review on Manipulation of Essential Metal Ions as Nanomedicine for Cancer Therapy

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