2022
DOI: 10.1002/ajoc.202100744
|View full text |Cite
|
Sign up to set email alerts
|

An Overview on Indole Aryl Sulfide/Sulfone (IAS) as Anti‐HIV Non‐Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)

Abstract: Sulfur‐containing indoles are widely studied against different biological targets. Among several potential drug candidates, seven molecules of this class are in the current market and a few of them are either in pipeline or in different stages of clinical trials. Particularly, arylthioindoles or indolylarylsulfones (IAS) received great attention by medicinal chemists due to their pharmokinetic profiles and wide spectrum of biological activities like antiviral, anticancer, cardiovascular, and antibacterial prop… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
6
0

Year Published

2022
2022
2025
2025

Publication Types

Select...
8
1

Relationship

2
7

Authors

Journals

citations
Cited by 14 publications
(6 citation statements)
references
References 70 publications
0
6
0
Order By: Relevance
“…We further examined the use of palladium as another metal species (entries 7− 10), and when Pd(PPh 3 ) 4 , PdCl 2 (PPh 3 ) 2 , or (DPPF)PdCl 2 was used as the catalyst, the reaction did not proceed at all. However, when Pd(CF 3 CO 2 ) 2 , a highly Lewis acidic palladium, was used as a catalyst, only indole compound 2a with the tosyl group rearranged to position 3 was quantitatively obtained.…”
Section: T H Imentioning
confidence: 99%
See 1 more Smart Citation
“…We further examined the use of palladium as another metal species (entries 7− 10), and when Pd(PPh 3 ) 4 , PdCl 2 (PPh 3 ) 2 , or (DPPF)PdCl 2 was used as the catalyst, the reaction did not proceed at all. However, when Pd(CF 3 CO 2 ) 2 , a highly Lewis acidic palladium, was used as a catalyst, only indole compound 2a with the tosyl group rearranged to position 3 was quantitatively obtained.…”
Section: T H Imentioning
confidence: 99%
“…Sulfonyl indoles are known as biologically active compounds (Scheme 2). 10 For example, indole compounds with a phenylsulfonyl group at position 3 were developed as reverse transcriptase inhibitors for HIV (human immunodeficiency virus). 11 Indole compounds with a phenylsulfonyl group at position 5 are known to have high affinity for 5-HT 3 (serotonin) receptors and are expected to be applied as antidepressant drugs.…”
mentioning
confidence: 99%
“…Indole alkaloids represent a well-known natural product, and majority of these alkaloids exhibit a variety of biological effect, such as antiviral, antitumor, antibacterial, antifungal, and antiplasmodial activities. [34][35][36][37] In particular, indole derivatives have been considered as one class of promising HIV-1 inhibitors targeting reverse transcriptase, protease, and CCR5. 38 Moreover, indole-b-diketo acid 5a was reported to inhibit the strand transfer process of integration, 39 and indole derivative was proved to be a allosteric inhibitor of HIV-1 integrase.…”
Section: Introductionmentioning
confidence: 99%
“…In the sulfenylation of organic compounds, the sulfenylating agents are important factors, and the commonly utilized chemicals include thiols [16][17][18], disulfides [19][20][21][22], sulfenyl halides [23][24][25], sulfonamides [26], sulfenate esters [27,28], and methyl(bismethylthio)sulfonium salts [29,30]. Among various organic molecules, aryl sulfides are recognized as functional materials and indispensable synthetic intermediates in drug discovery [31][32][33]. Because of their value, constructing C-S bonds has attracted significant attention via metal-catalyzed cross-coupling reactions and metal-free C-S bond formation [34][35][36][37].…”
Section: Introductionmentioning
confidence: 99%