An overview on jaundice measurement and application in biomedical: The potential of non-invasive method

Zulkarnay, Zakaria; Jurimah, A. J.; Ibrahim, Badaruddin; Shazwani, S.; Cheng, E. M.; Ruzairi, Abdul Rahim; Nasir, Muhammad

doi:10.1109/icobe.2015.7235896

Cited by 2 publications

(5 citation statements)

References 29 publications

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“…2 and Fig. 3 on the measured light attenuation, which have not accounted for in the employed forward model in (6). In addition, the wavelength varying scattering coefficients would have different influence on the amount of light being backscattered onto the detector at each wavelength; therefore it is inappropriate to represent these effects with a constant parameter G in (6).…”

Section: Resultsmentioning

confidence: 99%

“…3 on the measured light attenuation, which have not accounted for in the employed forward model in (6). In addition, the wavelength varying scattering coefficients would have different influence on the amount of light being backscattered onto the detector at each wavelength; therefore it is inappropriate to represent these effects with a constant parameter G in (6). This, together with the wavelength-dependent absorptivity of the medium's absorbers, would also modify the light path-length value, d, in (6) at different wavelength [46], [47].…”

Section: Resultsmentioning

confidence: 99%

“…This was accomplished by fitting the simulations (of different Cbil range of 0.32 -0.64 g/l shown in Fig. 4) using the MLB in (6). This process required the extinction coefficients of bilirubin and hemoglobin components in the wavelength range of 440 -500 nm as its priori knowledge following the equation in (6).…”

Section: Modified Lambert Beer Model and Fitting Proceduresmentioning

confidence: 99%

“…4) using the MLB in (6). This process required the extinction coefficients of bilirubin and hemoglobin components in the wavelength range of 440 -500 nm as its priori knowledge following the equation in (6). The fitting process began by initializing all the unknowns with value '1', the optimal value was iteratively sought based on the absolute difference between the value given by the simulated attenuation and the values given by MLB, ΔE.…”

Section: Modified Lambert Beer Model and Fitting Proceduresmentioning

confidence: 99%

“…The unconjugated bilirubin is bounded with albumin, which would be transported to the liver. During the transferring process, the unconjugated bilirubin would be converted into conjugated bilirubin, which is water-soluble, before it was excreted from the human body through sweating and defecation system [6]. The conventional method of determining the elevation of the bilirubin level is via the observation of the yellowish of white eyes and skin.…”

Section: Introductionmentioning

confidence: 99%

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Modified lambert beer for bilirubin concentration and blood oxygen saturation prediction

Ong

Huong

Ngu

et al. 2019

Int. J. Adv. Intell. Informatics

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Noninvasive measurement of health parameters such as blood oxygen saturation and bilirubin concentration predicted via an appropriate light reflectance model based on the measured optical signals is of eminent interest in biomedical research. This is to replace the use of conventional invasive blood sampling approach. This study aims to investigate the feasibility of using Modified Lambert Beer model (MLB) in the prediction of one’s bilirubin concentration and blood oxygen saturation value, SO2. This quantification technique is based on a priori knowledge of extinction coefficients of bilirubin and hemoglobin derivatives in the wavelength range of 440 – 500 nm. The validity of the prediction was evaluated using light reflectance data from TracePro raytracing software for a single-layered skin model with varying bilirubin concentration. The results revealed some promising trends in the estimated bilirubin concentration with mean ± standard deviation (SD) error of 0.255 ± 0.025 g/l. Meanwhile, a remarkable low mean ± SD error of 9.11 ± 2.48 % was found for the predicted SO2 value. It was concluded that these errors are likely due to the insufficiency of the MLB at describing changes in the light attenuation with the underlying light absorption processes. In addition, this study also suggested the use of a linear regression model deduced from this work for an improved prediction of the required health parameter values.

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Section: Resultsmentioning

confidence: 99%