An overview on novel synthetic approaches and medicinal applications of benzimidazole compounds

Hashem, Heba E.; Bakri, Youness El

doi:10.1016/j.arabjc.2021.103418

Cited by 36 publications

(26 citation statements)

References 72 publications

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“…Other intriguing functions of other substituted thiadiazole moieties have been discovered, such as analgesic activity, anti-microbial, anti-tubercular, anti-depressant, anti-oxidant, anti-convulsant, and anti-fungal. Another heterocyclic ring such as benzimidazole, a benzene-fused heterocyclic molecule, has received considerable attention in the field of modern medicinal chemistry because of its biological application [11]. Benzimidazole, the benzo derivative of imidazole, is a bicyclic aromatic chemical molecule composed of a six-membered benzene ring fused to a five-membered imidazole ring at the 4-and 5-positions [12].…”

Section: Introductionmentioning

confidence: 99%

Anticancer Biological Profile of Some Heterocylic Moieties-Thiadiazole, Benzimidazole, Quinazoline, and Pyrimidine

Sidat¹,

Jaber²,

Vekariya³

et al. 2022

Pharmacophore

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Several five and six-membered aromatic systems with three heteroatoms such as S, O, and N have been intensively researched due to their intriguing pharmacological properties. Heterocyclic compounds are chemicals that allow life to exist. Aside from that, all heteroatoms in the ring interact better with amino acids, and these interactions aid in reducing transactivation, and enhancing lipophilicity, solubility, and absorption, all of which can be exploited to improve therapeutic action. Heterocyclic nucleus 1,3,4-thiadiazole, benzimidazole, quinazoline, and pyrimidine derivatives have shown considerable biological actions such as anticancer, antimicrobial, anti-inflammatory, antidepressant, antioxidant, antifungal, antimicrobial, Carbonic anhydrase inhibitors, anticonvulsant, antibacterial activity, etc. All ring system members play a significant role in the development of novel drugs. In this review, we have highlighted the FDA approved drugs of heterocyclic compound which will pave the way for development of new entities. The current analysis focuses on synthetic derivatives of thiadiazole, benzimidazole, quinazoline, and pyrimidine that have significant anticancer biological effects on several cancer cell lines.

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Section: Introductionmentioning

confidence: 99%

Anticancer Biological Profile of Some Heterocylic Moieties-Thiadiazole, Benzimidazole, Quinazoline, and Pyrimidine

Sidat¹,

Jaber²,

Vekariya³

et al. 2022

Pharmacophore

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show abstract

“…[27][28][29] Structural modifications at the 2, 5 and 6 positions on the benzimidazole scaffold have provided a wide spectrum of compound classes as well as the scope for the enhancement of activity. 23,30,31 Based on the comparative analysis of structures of various substituted benzimidazole derivatives as antimicrobial agents, it was noted that a bulky aromatic or heteroaromatic moiety and electron-rich group is required at either N-1 or C-2 through a linker of appropriate length. 32,33 Benzimidazoles are purinomimetics that have the potential to readily interact with the various biopolymers found in living systems.…”

Section: Introductionmentioning

confidence: 99%

“…27–29 Structural modifications at the 2, 5 and 6 positions on the benzimidazole scaffold have provided a wide spectrum of compound classes as well as the scope for the enhancement of activity. 23,30,31…”

Section: Introductionmentioning

confidence: 99%

Novel tetrahydropyrimidinyl-substituted benzimidazoles and benzothiazoles: synthesis, antibacterial activity, DNA interactions and ADME profiling

et al. 2022

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“…On the other hand, the efficient synthesis of nitrogen containing heterocyclic compounds is a hot topic in organic synthesis . Specially, indazoloquinolines are widely present in biological molecules and fluorescence materials, for example, OLED electron luminescent devices and potent inhibitors of anticancer.…”

mentioning

confidence: 99%

Rh(III)-Catalyzed Synthesis of Indazolo[2,3-a]quinolines: Vinylene Carbonate as C1 and C2 Building Blocks

et al. 2022

Org. Lett.

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A rhodium-catalyzed cyclization of azobenzenes and vinylene carbonate via C−H bond activation to construct indazolo[2,3-a]quinolines has been developed. This protocol offers an efficient method for synthesis of the titled products in good yields with broad functional group tolerance. In this reaction, three C−C bonds and C−N bond are formed in one pot, and vinylene carbonate (VC) acts as C1 and C2 synthons as well as "vinylene transfer" agent and acylation reagent in the construction of targetfused heterocycles. Moreover, the products exhibit favorable fluorescence properties, which indicate their potential application as fluorescent materials and biosensors.

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An overview on novel synthetic approaches and medicinal applications of benzimidazole compounds

Cited by 36 publications

References 72 publications

Anticancer Biological Profile of Some Heterocylic Moieties-Thiadiazole, Benzimidazole, Quinazoline, and Pyrimidine

Anticancer Biological Profile of Some Heterocylic Moieties-Thiadiazole, Benzimidazole, Quinazoline, and Pyrimidine

Novel tetrahydropyrimidinyl-substituted benzimidazoles and benzothiazoles: synthesis, antibacterial activity, DNA interactions and ADME profiling

Rh(III)-Catalyzed Synthesis of Indazolo[2,3-a]quinolines: Vinylene Carbonate as C1 and C2 Building Blocks

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