An Overview on Nutraceuticals and Herbal Supplements for Diabetes and Metabolic Syndrome

Najm, Wadie I.

doi:10.1016/b978-0-12-385083-6.00028-0

Cited by 3 publications

(1 citation statement)

References 55 publications

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“…Moreover, Ziegler ( 2004 ) have found that ALA has potential beneficial effects against obesity-induced complications including metabolic syndrome, insulin resistance, type II diabetes, and vascular damage. Although the wide safety margin of ALA, some rare adverse effects have been reported with very high doses of ALA (Emir et al 2018 ) and in case of thiamine deficiency (Najm 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of alpha-lipoic acid and caffeine-loaded chitosan nanoparticles on obesity and its complications in liver and kidney in rats

Sawie

Khadrawy

El-Gizawy

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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The present work investigated the effect of α-lipoic acid (ALA) and caffeine-loaded chitosan nanoparticles (CAF-CS NPs) on obesity and its hepatic and renal complications in rats. Rats were divided into control, rat model of obesity induced by high fat diet (HFD), and obese rats treated with ALA and/or CAF-CS NPs. At the end of the experiment, the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) and the levels of urea, creatinine, interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) were determined in the sera of animals. In addition, malondialdehyde (MDA), nitric oxide (NO), and reduced glutathione (GSH) were measured in hepatic and renal tissues. Renal Na+, K+-ATPase was assessed. The histopathological changes were examined in the hepatic and renal tissues. Obese rats showed a significant increase in AST, ALT, ALP, urea, and creatinine. This was associated with a significant increase in IL-1β, TNF-α, MDA, and NO. A significant decrease in hepatic and renal GSH and renal Na+, K+-ATPase activity was recorded in obese rats. Obese rats also showed histopathological alterations in hepatic and renal tissues. Treatment with ALA and/or CAF-CS NPs reduced the weight of obese rats and ameliorated almost all the hepatic and renal biochemical and histopathological changes induced in obese rats. In conclusion, the present findings indicate that ALA and/or CAF-CS NPs offered an effective therapy against obesity induced by HFD and its hepatic and renal complications. The therapeutic effect of ALA and CAF-CS NPs could be mediated through their antioxidant and anti-inflammatory properties.

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Section: Introductionmentioning

confidence: 99%

Effect of alpha-lipoic acid and caffeine-loaded chitosan nanoparticles on obesity and its complications in liver and kidney in rats

Sawie

Khadrawy

El-Gizawy

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Synthesis of poly vinyl chloride/chlorinated polypropylene-active natural substance derivatives for potential packaging materials application. Tannic acid, menthol and lipoic acid

Hazer

Ashby

2023

Food Chemistry

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Neuropsychiatric impact of antibiotic administration on social behavior in zebrafish: Investigating the antioxidant role of alpha lipoic acid

Rarinca,

Visternicu,

Ionescu

et al. 2024

BPI

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Behavioral studies on zebrafish (Danio rerio) provide valuable insights into the effects of various compounds on aquatic organisms. This study examines the impact of alpha-lipoic acid (ALA), ampicillin (AMP), and their combination (AMP+ALA) on zebrafish behavior during a 96-hour exposure period. Behavioral responses were evaluated using the social interaction test, which measured sociability, and the swimming performance test, assessing locomotor activity and endurance. The experimental design included a control group and three treatment groups: ampicillin, alpha-lipoic acid, and a combination of both. Ampicillin exposure resulted in reduced social interaction and swimming performance, while alpha-lipoic acid showed a protective effect, improving these parameters. The combination treatment produced variable results, suggesting potential interactions between the compounds. These findings highlight the behavioral effects of these substances and their significance for understanding compound interactions in aquatic models.

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An Overview on Nutraceuticals and Herbal Supplements for Diabetes and Metabolic Syndrome

Cited by 3 publications

References 55 publications

Effect of alpha-lipoic acid and caffeine-loaded chitosan nanoparticles on obesity and its complications in liver and kidney in rats

Effect of alpha-lipoic acid and caffeine-loaded chitosan nanoparticles on obesity and its complications in liver and kidney in rats

Synthesis of poly vinyl chloride/chlorinated polypropylene-active natural substance derivatives for potential packaging materials application. Tannic acid, menthol and lipoic acid

Neuropsychiatric impact of antibiotic administration on social behavior in zebrafish: Investigating the antioxidant role of alpha lipoic acid

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