An Overview on Synthesis and Biological Activity of Chalcone Derived Pyrazolines

Abstract

Chalcones are α, β unsaturated aromatic ketones having enone moiety and exhibit a wide array of pharmaceutical and biological activities. Chalcones possess a wide range of biological activities such as anticancer, antituberculosis, antidiabetic, antioxidant, anti‐inflammatory, antimicrobial, and antimalarial. Nitrogen‐containing heterocyclic compounds are an extremely important class of organic compounds with a broad spectrum of pharmaceutical activities. Pyrazolines are N‐ heterocyclic compounds that exhibit a wide range of pharmaceutical activities and are synthesized from chalcone with enhanced biological activity. The present study summarizes the chemistry of various chalcone‐based pyrazolines and their derivatives with the available data till 2021.

Cyclization of arylhydrazones of cross-conjugated enynones: synthesis of luminescent styryl-1H-pyrazoles and propenyl-1H-pyrazoles

“…Due to the unique electronic structure of pyrazole/pyrazoline heterocycles, their functional derivatives have received a lot of attention from researchers. 1 Some of the recent research data (for example, see 2021 reviews 2 and the references therein) demonstrate that pyrazoles and their partially hydrogenated analogues are considered to be the most convenient basic structures for the creation of compounds with a wide variety of biological activities and practical photophysical properties.…”

A novel synthetic approach to Pyrazolooxazines. One‐pot synthesis of Pyrazolo[5,1‐c][1,4]oxazine derivatives from 2,2‐dichlorovinylacetophenones

“…Given the well-known biological interest of pyrazolines [31][32][33], the report of the synthesis of compounds 7, for the first time, gains added significance. It should also be noted that, from a synthetic point of view, a direct conversion of compounds 4 to products 7 is a valuable result in itself.…”

Two-Photon Absorption and Multiphoton Excited Fluorescence of Acetamide-Chalcone Derivatives: The Role of Dimethylamine Group on the Nonlinear Optical and Photophysical Properties

“…Moreover, when strong EW/ED groups are attached to the chalcone backbone, a high emissive state may be created, allowing applications involving DNA or metal ion detection [ 18 ]. In this regard, fluorescent-based chalcones are great candidates for fluorescence microscopy applications [ 19 , 20 , 21 ] because, besides the high biological activity [ 22 ] of chalcone derivatives, they present low interference with the target of interest [ 23 ]. Additionally, multiphoton fluorescence microscopy presents relevant advantages over single-photon ones, such as infrared excitation and high-resolution excitation, making compounds able to present fluorescence triggered by multiphoton absorption as a select class of compounds to be investigated.…”