2018
DOI: 10.3390/ijms19123898
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An Overview on the Anticancer Activity of Azadirachta indica (Neem) in Gynecological Cancers

Abstract: In recent years, a wide range of studies have pointed out the importance of nutraceuticals as reservoirs of therapeutic compounds for several diseases, including cancer. This study is centered on the role of some nutraceuticals as anticancer agents and on their efficiency in the oncological gynecological field. Gynecological cancers include cervical, ovarian, and breast neoplasia and these are the major causes of morbidity and mortality in the female population. Cervical neoplasia affects sexually active women… Show more

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Cited by 53 publications
(40 citation statements)
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“…Breast cancer is the most common cancer among women of reproductive age [49]. The antiproliferative activity of gedunin against MCF-7 and SkBr3 breast cancer cells lines is reported by Brandt et al [24].…”
Section: Gynecologic Cancers and Associated Cancersmentioning
confidence: 95%
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“…Breast cancer is the most common cancer among women of reproductive age [49]. The antiproliferative activity of gedunin against MCF-7 and SkBr3 breast cancer cells lines is reported by Brandt et al [24].…”
Section: Gynecologic Cancers and Associated Cancersmentioning
confidence: 95%
“…Ovarian cancer is the fifth leading cause of death among women [49]. The first approach to the effect of gedunin on ovarian cell line was performed by Kamath et al [28].…”
Section: Gynecologic Cancers and Associated Cancersmentioning
confidence: 99%
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“…Les effets anticancéreux des composés issus d'A. indica ont été démontrés dans les cancers gynécologiques [11,16], mais aussi dans les cancers gastrointestinaux, du sein, de la prostate, de la peau et du sang [11]. L'azadirachtine est considérée comme non-toxique pour les hommes et les vertébrés à sang chaud [6] et sans génotoxicité pour les mammifères [19].…”
Section: Revuesunclassified
“…Azadirachta indica, réputé dans la médecine traditionnelle en Asie et en Afrique, est utilisé pour traiter de multiples affections ( Figure 2) : les allergies (comme antihistaminique), l'asthme, les céphalées, les infections microbiennes et virales, le paludisme, les calculs rénaux, le diabète, mais aussi les maladies cardiovasculaires (hypertension, athérosclérose), gastriques (ulcères) et dermatologiques (plaies septiques, furoncles, démangeaisons dues à la varicelle, gale, leishmaniose). Azadirachta indica présente aussi des propriétés fongicides, antiparasitaires (helminthes), antipyrétiques, anti-inflammatoires immunostimulantes, immunomodulatrices, neuroprotectrices (dans la maladie de Parkinson), contraceptives et anticancéreuses [8][9][10][11][13][14][15][16][17]. Le potentiel fongicide du margousier semble lié à la présence d'azadirachtine et de nimbine [8] ; son effet anticarcinogène reposerait sur l'azadirachtine et le nimbolide [9].…”
Section: Effets Bénéfiques De Azadirachta Indicaunclassified