An Overview on the Biological Perspectives of Aglaia Species

Priya, R; P, Sowmiya; Muthuraman, Meenakshi Sundaram

doi:10.22159/ajpcr.2018.v11i9.26436

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…Aglaia is a genus in the Meliaceae family, which is also the largest genus in this family, widely distributed in the tropical rain forests of Southeast Asia, including Indonesia and Malaysia [10]. Aglaia plants are known to contain various secondary metabolites with interesting biological activities like anticancer, anti-inflammatory, antioxidant, antimicrobial, and antidiabetic [11].…”

Section: Introductionmentioning

confidence: 99%

Isolation, Structure Determination, and Cytotoxic Activity of Steroid Compound from The Stem Bark of Aglaia cucullata (Meliaceae)

Farabi,

Harneti,

Nurlelasari

et al. 2023

J. Kim. Sains Apl.

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Steroids are one of the secondary metabolite groups that are abundant in many organisms. In plants, this type of compound is called phytosterols. Phytosterols have been widely known to show many potential bioactivities such as anti-inflammatory, induced apoptosis, cytotoxic, anti-diabetic, angiogenic, and antioxidant. One of the sources of phytosterol compounds is the genus Aglaia. As the largest genus in the Meliaceae family, the genus Aglaia contains many bioactive compounds, including steroids. This research reported the isolation, structural determination, and cytotoxic activity of steroid compounds from the stem bark of Aglaia cucullata, one of the members of the Aglaia genus. Pure isolated steroid was obtained after maceration of dried stem bark with ethanol and partitioned based on difference polarity, continued by column chromatography. Spectroscopic methods, including HRMS, FTIR, 1D and 2D NMR, were used for structural determination. The compound structure identified as stigmast-5-en-3β-ol-3β-oleate was first isolated from this species. MCF-7 breast cancer cell, B16-F10 melanoma cell, and CV-1 normal fibroblast kidney cell were used to evaluate its cytotoxicity. Stigmast-5-en-3β-ol-3β-oleate displayed low cytotoxicity against those two cancer cells and a normal cell.

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Section: Introductionmentioning

confidence: 99%

Isolation, Structure Determination, and Cytotoxic Activity of Steroid Compound from The Stem Bark of Aglaia cucullata (Meliaceae)

Farabi,

Harneti,

Nurlelasari

et al. 2023

J. Kim. Sains Apl.

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Update on Phytochemical and Biological Studies on Rocaglate Derivatives from Aglaia Species

et al. 2021

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With about 120 species, Aglaia is one of the largest genera of the plant family Meliaceae (the mahogany plants). It is native to the tropical rainforests of the Indo-Australian region, ranging from India and Sri Lanka eastward to Polynesia and Micronesia. Various Aglaia species have been investigated since the 1960s for their phytochemical constituents and biological properties, with the cyclopenta[b]benzofurans (rocaglates or flavaglines) being of particular interest. Phytochemists, medicinal chemists, and biologists have conducted extensive research in establishing these secondary metabolites as potential lead compounds with antineoplastic and antiviral effects, among others. The varied biological properties of rocaglates can be attributed to their unusual structures and their ability to act as inhibitors of the eukaryotic translation initiation factor 4A (eIF4A), affecting protein translation. The present review provides an update on the recently reported phytochemical constituents of Aglaia species, focusing on rocaglate derivatives. Furthermore, laboratory work performed on investigating the biological activities of these chemical constituents is also covered.

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An Overview on the Biological Perspectives of Aglaia Species

Cited by 2 publications

References 31 publications

Isolation, Structure Determination, and Cytotoxic Activity of Steroid Compound from The Stem Bark of Aglaia cucullata (Meliaceae)

Isolation, Structure Determination, and Cytotoxic Activity of Steroid Compound from The Stem Bark of Aglaia cucullata (Meliaceae)

Update on Phytochemical and Biological Studies on Rocaglate Derivatives from Aglaia Species

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