An overview on the potential of natural products as ureases inhibitors: A review

Abstract

Graphical abstract

Urease Inhibitors of Agricultural Interest Inspired by Structures of Plant Phenolic Aldehydes

“…27 Among them, methyl gallate (phenolic ester) and its glycosylated derivative isolated from Paeonia lactiflora roots were shown to be promising with respect to the inhibition of H. pylori urease. 37 The promising effect of these phenolic esters prompted us to investigate the potential of phenolic aldehyde derivatives as urease inhibitors of agricultural interest.…”

“…Nature is undoubtedly a source of metabolites with potential to interfere with the activity of ureases as determined by in vitro assays with pure enzymes from Helicobacter pylori or Canavalia ensiformis (jack bean). 27 Among natural products produced by plants, phenolic compounds, such as flavonoids, methyl gallate and stilbenoids have been shown to inhibit ureases. [28][29][30] Although there is no report on the ability of natural phenolic aldehydes to inhibit ureases, it is likely that such secondary metabolites may work on ureases or be good prototypes for the design of urease inhibitors.…”

Inhibition of Helicobacter pylori and Its Associated Urease by Two Regional Plants of San Luis Argentina

“…Thus, neutralizing or suppressing the expression of virulence factors that allow attenuates the pathogenicity of the bacterium and facilitate the elimination for the host innate immune system is desired to overcome infection (Fernebro, 2011). In this sense, urease inhibitors had been isolated from some plants and herbs (Amin et al, 2013;Hřibová et al, 2014;Modolo et al, 2015). We studied two regional plants that have not been screened yet for its urease inhibition activities in H. pylori strains in order to determine its effect on the main factor of colonization and virulence of the bacterium.…”

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“…Various infections of GIT and the UTI's have been associated with the increased pH due to presence of the urease that produces ammonia and may lead to pyelonephritis, kidney stone formation, hepatic encephalopathy and ultimately hepatic coma in human beings and animals [22][23] . The main problem is associated with the gram positive bacteria H. pylori that has ability to survive even at low pH values of stomach and is responsible for gastric and duodenal ulcers causing cancer of GIT.…”

“…The main problem is associated with the gram positive bacteria H. pylori that has ability to survive even at low pH values of stomach and is responsible for gastric and duodenal ulcers causing cancer of GIT. This is due to the fact that the urease enzyme gets attached to the surface of the bacteria and keeps on releasing the urea that promotes the existence and growth of H. pylori in gut of humans [24][25][26][27] .…”