An overview on the seven pathogenic human coronaviruses

Kesheh, Mina Mobini; Hosseini, Parastoo; Soltani, Saber; Zandi, Milad

doi:10.1002/rmv.2282

Cited by 123 publications

(105 citation statements)

References 115 publications

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“…Three new HCoVs have recently emerged with a significant mortality rate. Despite the fact that all HCoVs share similarities in viral replication, they differ in their accessory proteins, incubation period and pathogenicity (Modified by Kesheh et al, 2021 ).…”

Section: Severe Acute Respiratory Syndrome Coronavirus-2 and Receptormentioning

confidence: 99%

Is There a Role for SARS-CoV-2/COVID-19 on the Female Reproductive System?

et al. 2022

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Coronavirus disease (COVID-19) has emerged as a very serious pandemic caused by the rapidly evolving transmission of the coronavirus SARS-CoV-2. Since its outbreak in 2020, the SARS CoV-2 has represented an important challenge for the physicians due to its well known respiratory sequelae. To date, the role of SARS-CoV-2 infection on organs and systems other than lungs and respiratory tract remains less clear. In particular, it remains to be investigated whether the reproductive system can be affected by the SARS-CoV-2 in the long term-period or, in alternative, drugs used to treat COVID-19 might impact the reproductive systems and, in turn, fertility. What is known is that SARS-Cov-2 binds to target cells of host through different receptors including angiotensin-converting enzyme 2 (ACE2), neuropilin-1, AXL and antibody-FcɣR complexes. ACE2 physiologically regulates both the expression of angiotensin II (Ang II) as well as Ang-(1-7) to exerts its physiological functions. The reproductive system abundantly expresses ACE2 and produces Ang-(1-7), starting from precursors which are locally generated or derived from systemic circulation. Ang-(1-7) plays an important role of stimulus to the growth and maturation of ovarian follicle as well as to ovulation. Also human endometrium expresses Ang-(1-7), mainly during the post-ovulatory phase. Animal and human observational studies demonstrated that Ang-(1-7) is involved in the maternal immune response to pregnancy and its deficiency is associated with a defective placenta development. In our manuscript, we review the current knowledge about whether SARS-CoV-2 may impact the female reproductive system. We further explain the possible molecular mechanism by which SARS-CoV-2 might affect ovarian, endometrial and female genital tract cells.

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Section: Severe Acute Respiratory Syndrome Coronavirus-2 and Receptormentioning

confidence: 99%

Is There a Role for SARS-CoV-2/COVID-19 on the Female Reproductive System?

et al. 2022

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“…The cellular plasma membrane contains subdomains of lipid rafts composed of cholesterol and glycosphingolipids [41]. SARS-CoV-2 and SARS-CoV use the angiotensin-converting enzyme-2 (ACE2) receptor for cellular entry [42]. Interactions between the ACE2 receptor and the spike protein are facilitated by cholesterol-rich Clathrins, caveolins, and dynamin in lipid rafts play an important role in viral entry [43].…”

Section: Lipids and Coronavirus Entrymentioning

confidence: 99%

The role of lipids in the pathophysiology of coronavirus infections

Zandi¹,

Hosseini

Soltani

et al. 2021

Osong Public Health Res Perspect

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Coronaviruses, which have been known to cause diseases in animals since the 1930s, utilize cellular components during their replication cycle. Lipids play important roles in viral infection, as coronaviruses target cellular lipids and lipid metabolism to modify their host cells to become an optimal environment for viral replication. Therefore, lipids can be considered as potential targets for the development of antiviral agents. This review provides an overview of the roles of cellular lipids in different stages of the life cycle of coronaviruses.

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“…COVID-19 is caused by SARS-CoV-2, a beta-coronavirus of lineage B. It encodes four structural proteins: [1] the spike-surface glycoprotein [2] , the small envelope protein [3] , the membrane glycoprotein, and [4] the nucleocapsid protein, as well as several nonstructural proteins; however, HE is encoded by other betacoronaviruses in lineage A, including HCoV-OC43, HCoV-HKU1, BCoV, and MHV [2] , [8] .…”

mentioning

confidence: 99%