An overview on the synthesis and recent applications of conducting poly(3,4-ethylenedioxythiophene) (PEDOT) in industry and biomedicine

Rahimzadeh, Zahra; Naghib, Seyed Morteza; Zare, Yasser; Rhee, Kyong Yop

doi:10.1007/s10853-020-04561-2

Cited by 76 publications

(31 citation statements)

References 276 publications

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“…The hydrogels are cell adhesive and show cytocompatibility besides their electrical functionality. Comprehensive literature reviews on CPs [23,[63][64][65] and 3D-printed conductive hydrogels for biomedical and tissue engineering applications have been reported. [32,39,66] However, the main literature on similar alginate-based materials as used here mainly consists of alginate-PPy composites, [64,[67][68][69][70][71] and oxidized alginate-PPy systems have been explored recently.…”

Section: Discussionmentioning

confidence: 99%

Electrically Conductive and 3D‐Printable Oxidized Alginate‐Gelatin Polypyrrole:PSS Hydrogels for Tissue Engineering

Distler

Polley

Shi

et al. 2021

Adv Healthcare Materials

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Electroactive hydrogels can be used to influence cell response and maturation by electrical stimulation. However, hydrogel formulations which are 3D printable, electroactive, cytocompatible, and allow cell adhesion, remain a challenge in the design of such stimuli‐responsive biomaterials for tissue engineering. Here, a combination of pyrrole with a high gelatin‐content oxidized alginate‐gelatin (ADA‐GEL) hydrogel is reported, offering 3D‐printability of hydrogel precursors to prepare cytocompatible and electrically conductive hydrogel scaffolds. By oxidation of pyrrole, electroactive polypyrrole:polystyrenesulfonate (PPy:PSS) is synthesized inside the ADA‐GEL matrix. The hydrogels are assessed regarding their electrical/mechanical properties, 3D‐printability, and cytocompatibility. It is possible to prepare open‐porous scaffolds via bioplotting which are electrically conductive and have a higher cell seeding efficiency in scaffold depth in comparison to flat 2D hydrogels, which is confirmed via multiphoton fluorescence microscopy. The formation of an interpenetrating polypyrrole matrix in the hydrogel matrix increases the conductivity and stiffness of the hydrogels, maintaining the capacity of the gels to promote cell adhesion and proliferation. The results demonstrate that a 3D‐printable ADA‐GEL can be rendered conductive (ADA‐GEL‐PPy:PSS), and that such hydrogel formulations have promise for cell therapies, in vitro cell culture, and electrical‐stimulation assisted tissue engineering.

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Section: Discussionmentioning

confidence: 99%

Electrically Conductive and 3D‐Printable Oxidized Alginate‐Gelatin Polypyrrole:PSS Hydrogels for Tissue Engineering

Distler

Polley

Shi

et al. 2021

Adv Healthcare Materials

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“…Biosensors have attracted much attention due to their unique properties such as simple procedure, easy production, fast response and cost efficiency [1][2][3]. Polyaniline (PANI) is a semi-flexible conducting polymer of the organic semiconductor family [4], which has attracted intensive interest as a result of remarkable features including superior conductivity [5], environmental stability [6], intriguing redox process [7] and inexpensive starting material [8]. In multidisciplinary areas, various applications for PANI have been reported such as biosensors, supercapacitors, biofuel cells, actuators, corrosion protection, membranes, solar cell devices, and rechargeable batteries [4,[9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

A highly sensitive biosensor based on methacrylated graphene oxide-grafted polyaniline for ascorbic acid determination

Naghib

Behzad

Rahmanian

et al. 2020

Nanotechnology Reviews

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Functionalized graphene-based nanocomposites have opened new windows to address some challenges for increasing the sensitivity, accuracy and functionality of biosensors. Polyaniline (PANI) is one of the most potentially promising and technologically important conducting polymers, which brings together the electrical features of metals with intriguing properties of plastics including facile processing and controllable chemical and physical properties. PANI/graphene nanocomposites have attracted intense interest in various fields due to unique physicochemical properties including high conductivity, facile preparation and intriguing redox behavior. In this article, a functionalized graphene-grafted nanostructured PANI nanocomposite was applied for determining the ascorbic acid (AA) level. A significant current response was observed after treating the electrode surface with methacrylated graphene oxide (MeGO)/PANI nanocomposite. The amperometric responses showed a robust linear range of 8–5,000 µM and detection limit of 2 µM (N = 5). Excellent sensor selectivity was demonstrated in the presence of electroactive components interfering species, commonly found in real serum samples. This sensor is a promising candidate for rapid and selective determination of AA.

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“…The employment of PEDOT:PSS is justified by the largely enhanced processability and water solubility [79] of the composite material, but it provides relatively low conductivity (0.1 to 10 S cm -1 ) [74,316] and the further doping of the organic matrix is usually required. These treatments involve the use of solvents, acids, and/or doping agents (ionic liquids, salts, CNTs) that could jeopardize the final sustainability of the device.…”

Section: Sustainability Of Poly(34-ethylenedioxythio Phene):poly(styrene Sulfonic Acid): An Open Discussionmentioning

confidence: 99%

“…[71] It was invented at the Bayer AG research laboratories around 40 years ago [72] and its excellent conductivity (300-500 S cm −1 ), high flexibility, excellent transparency in visible light, remarkable stability, and low cost (even if an accurate and comparative LCA is still missing) make it among the most desired polymeric organic conductors of interest for electronic, antistatic and optoelectronic applications. [73][74][75] PEDOT is an insoluble polymer and it leads to difficult deposition processes from solution, but this issue was fixed by using a water-soluble polyelectrolyte, for example, poly(styrene sulfonic acid) (PSS), as the charge-balancing dopant during polymerization; as a result, PEDOT:PSS was obtained from the reaction. [76][77][78] The product of this important technical breakthrough (water processability) was sold as Baytron P™.…”

Section: Introductionmentioning

confidence: 99%

Poly(3,4‐ethylenedioxythiophene) in Dye‐Sensitized Solar Cells: Toward Solid‐State and Platinum‐Free Photovoltaics

Fagiolari

Varaia

Mariotti

et al. 2021

Advanced Sustainable Systems

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Dye-sensitized solar cells (DSSCs) have become a strong reality in the field of hybrid photovoltaics. Their ability to operate in diffused light conditions and the possibility of fabrication of modules bearing different colors make these cells attractive for different applications, for example, wearable electronics, building integration, etc. This review focuses on one of the compounds rather often studied for DSSCs, namely, poly(3,4-ethylenedioxythiophene) (PEDOT). It has been introduced both as a substitute for liquid electrolytes, in order to facilitate cells fabrication and increase their durability, and as an alternative to platinum for counter electrodes. The literature counts many studies on PEDOT and this manuscript collects them following a classification criterion based on applications, functionalization/doping strategies, and deposition methods. In addition to comparing the performance obtained for PEDOT-based systems with those of traditional cells (i.e., assembled with liquid iodine-based electrolytes and platinum cathodes), the manuscript also offers a brief analysis of costs and sustainability aspects, built up on experimental data found in the literature; this latter is expected to constitute a precious resource to catalyze the attention of the scientific community on relevant and preliminary aspects when figuring out the industrial scalability of newly proposed cell components.

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An overview on the synthesis and recent applications of conducting poly(3,4-ethylenedioxythiophene) (PEDOT) in industry and biomedicine

Cited by 76 publications

References 276 publications

Electrically Conductive and 3D‐Printable Oxidized Alginate‐Gelatin Polypyrrole:PSS Hydrogels for Tissue Engineering

Electrically Conductive and 3D‐Printable Oxidized Alginate‐Gelatin Polypyrrole:PSS Hydrogels for Tissue Engineering

A highly sensitive biosensor based on methacrylated graphene oxide-grafted polyaniline for ascorbic acid determination

Poly(3,4‐ethylenedioxythiophene) in Dye‐Sensitized Solar Cells: Toward Solid‐State and Platinum‐Free Photovoltaics

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