An Overview to Molecularly Imprinted Electrochemical Sensors for the Detection of Bisphenol A

Abstract

Bisphenol A (BPA) is an industrial chemical used extensively in plastics and resins. However, its endocrine-disrupting properties pose risks to human health and the environment. Thus, accurate and rapid detection of BPA is crucial for exposure monitoring and risk mitigation. Molecularly imprinted electrochemical sensors (MIES) have emerged as a promising tool for BPA detection due to their high selectivity, sensitivity, affordability, and portability. This review provides a comprehensive overview of recent advances in MIES for BPA detection. We discuss the operating principles, fabrication strategies, materials, and methods used in MIES. Key findings show that MIES demonstrate detection limits comparable or superior to conventional methods like HPLC and GC-MS. Selectivity studies reveal excellent discrimination between BPA and structural analogs. Recent innovations in nanomaterials, novel monomers, and fabrication techniques have enhanced sensitivity, selectivity, and stability. However, limitations exist in reproducibility, selectivity, and stability. While challenges remain, MIES provide a low-cost portable detection method suitable for on-site BPA monitoring in diverse sectors. Further optimization of sensor fabrication and characterization will enable the immense potential of MIES for field-based BPA detection.

Optimizing Graphene Dopants for Direct Electrocatalytic Quantification of Small Molecules and Ions

“…The focus on optimizing these detection methods reflects the growing need for more reliable and robust diagnostic tools in health care and more stringent environmental monitoring systems. The ability to detect small molecules at lower concentrations and with higher accuracy has profound implications, including improved patient outcomes through early and precise diagnosis, more effective drug monitoring, and a better understanding of environmental pollutants' impact [23][24][25][26]. In summary, the pursuit of optimized detection methods for small molecules is driven by the need for accuracy, sensitivity, and practicality in both clinical and environmental contexts.…”