An Overview to the Cytotoxicity of Resin Based Dental Materials

Atalayın, Çiğdem; Tezel, Hüseyin; Ergücü, Zeynep

doi:10.5505/eudfd.2016.66487

Cited by 5 publications

(2 citation statements)

References 48 publications

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“…This can lead to permanent changes in the genetic material and potentially cause genetic disorders or diseases. 23 Before every new dental material is introduced to the market, it should be investigated for biological risks, and its biocompatibility should be evaluated by various methods before clinical use. The main principle of biocompatibility testing is to determine in advance the type and number of potential reactions between a material and a biological system and the type and amount of structural and functional changes in the living organism.…”

Section: Biocompatibility and Cytotoxicitymentioning

confidence: 99%

An overview to biocompatibility of resin based restorative materials

Avcılar,

Bakır,

Bakır

2023

JDSE

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Nowadays, resin based materials find a wide range of use in dentistry due to their aesthetic properties, mechanical durability and cost advantages. Dentistry materials; They can have an effect because they are in direct contact with various tissues such as gums, tongue, lips and cheeks, in addition to periodontium, pulp, dentin and enamel. It is important that resin materials produced with new technologies to be used in restorative dentistry not only have mechanical, physical, functional and aesthetic properties, but also be carefully evaluated in terms of biological compatibility. The purpose of this review is to review the basic concepts and methods related to biocompatibility, to present data from studies on the cytotoxicity of resin-based materials, and finally to make recommendations for clinical applications.

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Section: Biocompatibility and Cytotoxicitymentioning

confidence: 99%

An overview to biocompatibility of resin based restorative materials

Avcılar,

Bakır,

Bakır

2023

JDSE

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“…7, 8 In addition, residual monomers have been reported to cause a delay in odontogenic differentiation and mineralization processes in root cells and pulpal cells. 7 Dental materials should be evaluated for biological risks before clinical use. Biocompatibility is the ability of a material applied to living tissue to remain compatible without causing any change in the surrounding tissues.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of biocompatibility of four different one-step self-etching adhesives by animal experimental method

Aydın,

Bakır,

Bakır

2023

JDSE

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Aims: The success of materials used in dentistry is closely related to their biological safety. In recent years, there has been growing concern about the biocompatibility of self-etch adhesives, which are frequently used in restorative dental treatment. The aim of this study is to compare the biocompatibility of four different single-stage self-etch adhesive materials (Prime & Bond One Select, Optibond All-in-One, Clearfil Universal Bond, and Single Bond Universal) with the animal test method and evaluate them histopathologically. Methods: The experimental materials were polymerized by filling 10 mm-long, 2 mm-diameter polyurethane tubes. For each adhesive, 21 tubes were used. The tubes were placed in the subcutaneous pockets formed by four different incisions in the backs of 21 adult male albino rats. On the 7th, 30th, and 60th days, rats were randomly divided into three groups. At the end of these durations, the tube and the surrounding 2 cm2 of tissue were excised together. The sections were taken into preparation and stained with hematoxylen and eosin. The severity of inflammation, inflammatory cell count, and fibrous capsule thickness were evaluated histologically by light microscopy. Results: On the 7th day of samples, lesions due to acute inflammation, edema, and PMNL infiltration were observed. In the 30th-day samples, it was observed that inflammation decreased against all materials and fibrocollagen tissue increased. On the 60th day, granulation and fibrous tissue increased due to regeneration and reparation processes. On the 60th day, the number of inflammatory cells decreased significantly compared to the 7th day. When the fibrous tissue formation was evaluated, it was found that the 7th day score was significantly lower than the 60th day score. Conclusion: The severity of the inflammatory reaction at the beginning of all materials can be explained by the effects of residual monomer release and surgical trauma.

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