An ultra-compact and wireless tag for battery-free sweat glucose monitoring

Mirzajani, Hadi; Abbasiasl, Taher; Mirlou, Fariborz; Istif, Emin; Bathaei, Mohammad Javad; Dağ, Çağdaş; Deyneli, Oğuzhan; Yazıcı, Dilek; Beker, Levent

doi:10.1016/j.bios.2022.114450

Cited by 25 publications

(15 citation statements)

References 55 publications

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“…Beker et al have reported a battery-free wireless tag integrated with a footprint of 1.2 cm 2 for non-invasive monitoring of glucose [ 143 ]. The whole set-up was comprised of microfluidic channels for sweat collection, a glucose-sensitive enzymatic electrochemical sensor, an electronic chip for data processing, an antenna for data transmission to a smartphone and a wireless power supply.…”

Section: Nanomaterials Integrated Wearable Electrochemical Sensors@ N...mentioning

confidence: 99%

“… ( a ) Electrochemical response in presence of different concentrations of glucose, ( b ) on-body sweat analysis during physical exercise by the fabricated glucose tag, ( c ) the data of glucose concentration, measured in fabricated glucose tag from sweat and commercially available glucometers from the blood for the time period of 6 h, adopted with permission from Ref. [ 143 ], ( d ) photographic image of SWCNT-based flexible sensing array, ( e ) schematic illustration of the multiple sensing of sweat metabolites, amperometric response of the sensor array in the presence of increasing concentration ( f ) glucose and ( g ) lactate, and ( h , i ) photographs of the volunteers wearing intelligent wrist band for real-time sweat metabolites analysis, adopted with permission from Ref. [ 144 ].…”

Section: Figurementioning

confidence: 99%

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Electrochemical Nanosensors for Sensitization of Sweat Metabolites: From Concept Mapping to Personalized Health Monitoring

2023

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Sweat contains a broad range of important biomarkers, which may be beneficial for acquiring non-invasive biochemical information on human health status. Therefore, highly selective and sensitive electrochemical nanosensors for the non-invasive detection of sweat metabolites have turned into a flourishing contender in the frontier of disease diagnosis. A large surface area, excellent electrocatalytic behavior and conductive properties make nanomaterials promising sensor materials for target-specific detection. Carbon-based nanomaterials (e.g., CNT, carbon quantum dots, and graphene), noble metals (e.g., Au and Pt), and metal oxide nanomaterials (e.g., ZnO, MnO2, and NiO) are widely used for modifying the working electrodes of electrochemical sensors, which may then be further functionalized with requisite enzymes for targeted detection. In the present review, recent developments (2018–2022) of electrochemical nanosensors by both enzymatic as well as non-enzymatic sensors for the effectual detection of sweat metabolites (e.g., glucose, ascorbic acid, lactate, urea/uric acid, ethanol and drug metabolites) have been comprehensively reviewed. Along with this, electrochemical sensing principles, including potentiometry, amperometry, CV, DPV, SWV and EIS have been briefly presented in the present review for a conceptual understanding of the sensing mechanisms. The detection thresholds (in the range of mM–nM), sensitivities, linear dynamic ranges and sensing modalities have also been properly addressed for a systematic understanding of the judicious design of more effective sensors. One step ahead, in the present review, current trends of flexible wearable electrochemical sensors in the form of eyeglasses, tattoos, gloves, patches, headbands, wrist bands, etc., have also been briefly summarized, which are beneficial for on-body in situ measurement of the targeted sweat metabolites. On-body monitoring of sweat metabolites via wireless data transmission has also been addressed. Finally, the gaps in the ongoing research endeavors, unmet challenges, outlooks and future prospects have also been discussed for the development of advanced non-invasive self-health-care-monitoring devices in the near future.

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Section: Nanomaterials Integrated Wearable Electrochemical Sensors@ N...mentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Electrochemical Nanosensors for Sensitization of Sweat Metabolites: From Concept Mapping to Personalized Health Monitoring

2023

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“…[106] In recent years, sweat biosensing has received considerable attention for noninvasively CGM, since sweat can be conveniently collected and continuously monitored. [107][108][109] For example, Lee et al developed a closed-loop solution for noninvasive sweat glucose monitoring and microneedlebased point-of-care therapy, as well as pH, temperature, and humidity measurements. The simultaneous use of a series of integrated sensors can enhance the accuracy of glucose sensing by correcting pH-dependent deviation of the enzyme-based glucose sensor.…”

Section: Wearable Isf Cgmmentioning

confidence: 99%

Artificial intelligence biosensors for continuous glucose monitoring

Jin

Cai

et al. 2023

Interdisciplinary Materials

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Artificial intelligence (AI) algorithms in combination with continuous monitoring technologies have the potential to revolutionize chronic disease management. The recent innovations in both continuous glucose monitoring (CGM) and the closed‐loop highlight the far‐reaching potential of AI biosensors for individual healthcare. This review summarizes some of the most advanced progress made in CGM biosensing. We will focus on three main applications of AI algorithms in diabetes management: closed‐loop control algorithms, glucose predictions, and calibrations. The challenges and opportunities of AI technologies for CGM in individualized and proactive medicine will also be discussed.

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“…The vigorous milling and high-energy ablation process are effective for the manufacture of fluidic devices with robust materials such as glass [ 15 , 16 ], silicon [ 17 ], and polymers (i.e., PDMS, PMMA) [ 18 , 19 ], while the process may create surface defects for temperature sensitive, thin and fragile substrates. Laser processing, including CO 2 lasers and UV lasers, uses high energy to craft and create patterns on various hard substrates such as glass, borosilicate, silica, and quartz [ 20 ], and a few temperature-resisted polymer substrates [ 21 , 22 ]. However, the high-energy laser cutting process may not be suitable for temperature-sensitive polymer substrates or fire-catching cellulose or paper substrates resulting in a poor quality final product due to the melting, burning, and vaporization of substrate materials [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Craft-and-Stick Xurographic Manufacturing of Integrated Microfluidic Electrochemical Sensing Platform

et al. 2023

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An innovative modular approach for facile design and construction of flexible microfluidic biosensor platforms based on a dry manufacturing “craft-and-stick” approach is developed. The design and fabrication of the flexible graphene paper electrode (GPE) unit and polyethylene tetraphthalate sheet (PET)6/adhesive fluidic unit are completed by an economic and generic xurographic craft approach. The GPE widths and the microfluidic channels can be constructed down to 300 μm and 200 μm, respectively. Both units were assembled by simple double-sided adhesive tapes into a microfluidic integrated GPE (MF-iGPE) that are flexible, thin (<0.5 mm), and lightweight (0.4 g). We further functionalized the iGPE with Prussian blue and glucose oxidase for the fabrication of MF-iGPE glucose biosensors. With a closed-channel PET fluidic pattern, the MF-iGPE glucose biosensors were packaged and sealed to protect the integrated device from moisture for storage and could easily open with scissors for sample loading. Our glucose biosensors showed 2 linear dynamic regions of 0.05–1.0 and 1.0–5.5 mmol L−1 glucose. The MF-iGPE showed good reproducibility for glucose detection (RSD < 6.1%, n = 6) and required only 10 μL of the analyte. This modular craft-and-stick manufacturing approach could potentially further develop along the concept of paper-crafted model assembly kits suitable for low-resource laboratories or classroom settings.

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An ultra-compact and wireless tag for battery-free sweat glucose monitoring

Cited by 25 publications

References 55 publications

Electrochemical Nanosensors for Sensitization of Sweat Metabolites: From Concept Mapping to Personalized Health Monitoring

Electrochemical Nanosensors for Sensitization of Sweat Metabolites: From Concept Mapping to Personalized Health Monitoring

Artificial intelligence biosensors for continuous glucose monitoring

Craft-and-Stick Xurographic Manufacturing of Integrated Microfluidic Electrochemical Sensing Platform

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