An ultra-high-performance liquid chromatography-tandem mass spectrometry method for simultaneous determination of aflatoxins B1, B2, G1, G2, M1 and M2 in traditional Chinese medicines

Han, Zheng; Zheng, Yang; Luan, Lianjun; Cai, Zengxuan; Ren, Yiping; Wu, Yongjiang

doi:10.1016/j.aca.2010.02.009

Cited by 96 publications

(61 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study found that all the samples were contaminated with aflatoxin, though within permissible limits (<20 ppb) 34 . This result is consistent with several previous studies which also detected aflatoxin contaminants in Chinese herbs and the most commonly used roots, rhizomes and ripe fruits 35 .…”

supporting

confidence: 83%

Detection of microbes, aflatoxin and toxic heavy metals in Chinese medicinal herbs commonly consumed in Thailand

Rangsipanuratn¹,

Kammarnjassadakul²,

Janwithayanuchit³

et al. 2017

Pharm Sci Asia

View full text Add to dashboard Cite

The increasing popularity of Chinese herbal treatment has sparked interest in investigating how safe these alternative medicines are. This study scrutinized the Chinese herbs used most popularly in Thailand to identify the presence of heavy metals, microorganisms and aflatoxin contamination. Five commonly consumed Chinese herbs were investigated: Milkvetch root (Astragalus membranaceus), Chinese angelica (Angelica sinensis), Goji berry (Lycium barbarum), Chinese yam (Dioscorea opposita) and Jujube (Ziziphus jujuba). Any heavy metal (arsenic, lead, cadmium), microorganisms (total viable count; total aerobic microbial count, total combined yeast and mold count), pathogenic bacteria (Staphylococcus aureus, Salmonella spp., Clostridium spp.) or aflatoxin contamination were examined. Of the 25 samples, sixteen (64.0%) did not exceed acceptable limits. Nor did the total aerobic microbial count, total combined yeast and mold count, aflatoxin and heavy metals exceed permissible limits. Neither Salmonella spp., nor S. aureus were found in any of the samples. However, significant Clostridium spp. contamination (36.0%) was detected in 9 of the 25 samples. These health hazards should be addressed systematically and for the long term by the appropriate consumer protection agencies and related organizations.

show abstract

supporting

confidence: 83%

Detection of microbes, aflatoxin and toxic heavy metals in Chinese medicinal herbs commonly consumed in Thailand

Rangsipanuratn¹,

Kammarnjassadakul²,

Janwithayanuchit³

et al. 2017

Pharm Sci Asia

View full text Add to dashboard Cite

show abstract

“…Detection of AFB1 is important in food safety, quality control, environmental analysis, and toxin sensing. Currently, the existing methods for AFB1 detection are mainly based on high performance liquid chromatography (HPLC) [3] and immunoassay [4][5][6][7]. HPLC coupled with fluorescence detection or mass spectrometry has strength in high accuracy and good repeatability, but it usually needs time-consuming and laborious process.…”

Section: Introductionmentioning

confidence: 99%

Aptamer based surface plasmon resonance sensor for aflatoxin B1

Sun

Zhao

2017

Microchim Acta

View full text Add to dashboard Cite

The authors describe a surface plasmon resonance (SPR) based aptasensor for the carcinogenic mycotoxin aflatoxin B1 (AFB1) in a direct assay format. The aptamer is immobilized on the surface of a commercial sensor chip, and the SPR signal increases on binding of AFB1. The sensor chip can be fully regenerated by passing a flow of buffer over it upon which bound AFB1 dissociates from the aptamer. The biosensor works in the 0.4 nM to 200 nM AFB1 concentration range and has a 0.4 nM detection limit. It allows AFB1 to be determined in complex samples such as diluted red wine and beer. The assay is sensitive, and the chip is easily regenerated and stable. The method therefore overcomes certain limitations of antibody-based SPR assays and of competitive SPR assays for AFB1.

show abstract

“…Aflatoxins (AFT s) are the secondary metabolites mainly produced by Aspergillus flavus (2,3). This toxic substance, with four out of 20 different types which are known; including B1, B2, G1, and G2 could lead to some health problems (4). Among all the mycotoxins, Aflatoxin B1, B2, G1 and G2 could lead to some health problems such as acute and chronic poisoning among animals and human beings; hepatotoxic, cirrhosis and some malignancies as well as immunodeficiency causing recurrent infections (3,5), Faraji et al have reported that all samples of rice (60 specimens) contained AFT which AFT B1 and AFT B2 levels were found to be 2.55 and 0.34 µg/kg, respectively.…”

Section: Introductionmentioning

confidence: 99%

Determination of Aflatoxin in the Imported Rice in Zahedan, South-East of Iran, 2011

2013

View full text Add to dashboard Cite

Background: Rice is common foodstuffs in Iran. Aflatoxin contamination of rice can be hazardous human health and causes economic problems. Objectives: Determination of Aflatoxin levels was investigated on the imported rice which is consumed as the main food in this area. Materials and Methods: Two hundred samples of imported rice consisting; yellow (100) and white (100) rice were selected randomly. These samples were assessed for Aspergillus infection and the Aflatoxins B, G was detected by high performance liquid chromatography (HPLC) method. Results:The results showed, 33% and 47% of yellow and white rice samples had contaminated 0.34 and 0.58 part per billion (ppb) with Aflatoxin B1 respectively. It was observed 13% and 21% following samples had also contaminated 0.06 and 0.08 ppb Aflatoxin B2 respectively. The levels of G1 and G2 Aflatoxins were impossible to identify in these samples. Conclusions: According to proposed standards, none of the imported rice sample had not contaminated more than the maximum allowable concentrations of Aflatoxin.

show abstract

An ultra-high-performance liquid chromatography-tandem mass spectrometry method for simultaneous determination of aflatoxins B1, B2, G1, G2, M1 and M2 in traditional Chinese medicines

Cited by 96 publications

References 32 publications

Detection of microbes, aflatoxin and toxic heavy metals in Chinese medicinal herbs commonly consumed in Thailand

Detection of microbes, aflatoxin and toxic heavy metals in Chinese medicinal herbs commonly consumed in Thailand

Aptamer based surface plasmon resonance sensor for aflatoxin B1

Determination of Aflatoxin in the Imported Rice in Zahedan, South-East of Iran, 2011

Contact Info

Product

Resources

About