An Ultra-miniaturized Near Infrared Spectroscopy System to Assess Sleep Apnea in Children with Down Syndrome

Beppler, Eric; Dieffenderfer, James; Songkakul, Tanner; Krystal, Andrew D.; Bozkurt, Alper

doi:10.1109/embc.2018.8513038

Cited by 6 publications

(3 citation statements)

References 8 publications

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“…This model is a promising tool to investigate sleep disordered breathing in DS. However, as it is still a prototype, further clinical studies are needed to strengthen the evidence for its use 52 .…”

Section: Obstructive Sleep Apnea Is the Most Prevalent Sleep Disorder...mentioning

confidence: 99%

Sleep disorders in Down syndrome: a systematic review

Santos¹,

Costa²,

Linhares

et al. 2022

Arq. Neuro-Psiquiatr.

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Background: Sleep disorders are commonly observed in children with Down syndrome (DS) and can lead to significant behavioral and cognitive morbidities in these individuals. Objective: To perform a systematic review evaluating sleep disorders in individuals with DS. Methods: Search strategies were based on combinations of keywords: “Down syndrome”; “trisomy 21”; “sleep disorders”; “dyssomnias”; “sleep apnea”; “obstructive”; “sleeplessness”; “insomnia”; “parasomnias”; and “excessive daytime sleepiness”. PubMed and Science Direct were used. Only original studies and retrospective reviews in English published between January 2011 and March 2021 were included. Results: 52 articles were included, most of them involving children and adolescents under 18 years of age. The main sleep disorder associated with DS was obstructive sleep apnea (OSA). Some studies reported the presence of cognitive dysfunction in patients with DS and sleep-disordered breathing, and few have been found about parasomnia, insomnia, and daytime sleepiness in these patients. Movement disorders and unusual postures during sleep may be related to disordered sleep breathing in DS. The main treatment options for OSA are continuous positive airway pressure therapy (CPAP), surgery, and weight control. Computational modeling associated with MRI has been used to plan surgical interventions in these patients. Conclusions: Individuals with DS are at high risk of developing sleep-related breathing disorders. The main sleep disorder associated with DS was OSA. The presence of sleep-disordered breathing contributes to a worsening of cognitive function in patients with DS.

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Section: Obstructive Sleep Apnea Is the Most Prevalent Sleep Disorder...mentioning

confidence: 99%

Sleep disorders in Down syndrome: a systematic review

Santos¹,

Costa²,

Linhares

et al. 2022

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

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“…LED & photodiode Wrist (Braun et al, 2020) Forehead (Beppler et al, 2018) Ear (Davies et al, 2020) IPG Dry electrode Wrist (Schneider et al, 2018) Pulse pressure Pressure sensor Wrist (Meng et al, 2020) Respiration Body movement Strain gauge, accelerometer, magnetometer Chest (Klum et al, 2020), (Ding et al, 2018), (Ramírez et al, 2019), (Di Rienzo et al, 2018), (Milici et al, 2018) Head (Arnal et al, 2019) Air flow Humidity sensor Nose (Jin et al, 2017) Lung sound Stethoscope Chest (Klum et al, 2020) Movement EMG Dry electrode Leg (Jortberg et al, 2018) Actigraphy Accelerometer, gyroscope, magnetometer Wrist (Liao et al, 2020), (Kwasnicki et al, 2018) Leg (Bobovych et al, 2020) Chest (Ilen et al, 2019), (Kwasnicki et al, 2018) Body position Accelerometer, gyroscope, magnetometer Wrist (Kwasnicki et al, 2018) Chest (Yun et al, 2020), (Kwasnicki et al, 2018) Nose (Manoni et al, 2020) Others EDA Dry electrode Wrist (Romine et al, 2019), (Kim et al, 2021) Finger (Lam and Szypula, 2018) Tongue deformation Ultrasonic transducer Chin (Weng et al, 2017) Body temperature Thermometer Chest, wrist (Di Rienzo et al, 2018), (Liao et al, 2020) Snoring sound Microphone Forehead (Levendowski et al, 2017) ll OPEN…”

Section: Spo2mentioning

confidence: 99%

“…The forehead is another body location for pulse oximetry that is tested and validated. Beppler et al introduced an adhesive-bandage-type wireless device composed of LEDs and photodiodes, which attaches on the forehead to measure blood oxygen saturation (Beppler et al, 2018). The device tested on OSA patients could ll OPEN ACCESS capture repeated drops in blood oxygen saturation.…”

Section: Wearable Sensors and Electronics For Measuring Pulse During Sleepmentioning

confidence: 99%

Recent advances in wearable sensors and portable electronics for sleep monitoring

2021

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Despite the increasing awareness of the importance of sleep, the number of people suffering from insufficient sleep has increased every year. The gold-standard sleep assessment uses polysomnography (PSG) with various sensors to identify sleep patterns and disorders. However, due to the high cost of PSG and limited availability, many people with sleep disorders are left undiagnosed. Recent wearable sensors and electronics enable portable, continuous monitoring of sleep at home, overcoming the limitations of PSG. This report reviews the advances in wearable sensors, miniaturized electronics, and system packaging for home sleep monitoring. New devices available in the market and systems are collectively summarized based on their overall structure, form factor, materials, and sleep assessment method. It is expected that this review provides a comprehensive view of newly developed technologies and broad insights on wearable sensors and portable electronics toward advanced sleep monitoring as well as at-home sleep assessment. INTRODUCTIONWe spend almost one-third of our lifetime asleep. Sleep is an integral aspect of our life to sustain our daily activity, and the quality of sleep has a massive influence on our health, work performance, and well-being. Numerous research works have shown the association between the poor quality of sleep and many adverse effects on our health including, but not limited to, obesity, diabetes, heart diseases, hypertension, mood disorders, weakened immune system, and increased mortality risk (Buysse, 2014;Hublin et al., 2007;Patel et al., 2004;Sigurdson and Ayas, 2007). As an increasing number of people recognize sleep quality as a key component of a healthy lifestyle, research and industries related to sleep health have been actively growing. In 2019, the global sleep economy was $432 billion and was expected to grow up to $585 billion by 2024 with a compound annual growth rate (CAGR) of 6.3% (Casper, 2020). Especially when the COVID-19 outbreak has become a global pandemic, the importance of sleep is emphasized to support people's immunity and health (Gulia and Kumar, 2020;Huang and Zhao, 2020;Sher, 2020).Despite this elevated awareness of sleep health, the number of people with insufficient sleep or sleep disorders has continuously increased. In 2015, it was reported that 18% of the United States population took less than 6 h of sleep per day. Insufficient sleep caused reduced labor productivity and increased mortality, leading to an economic loss of $411 billion, which is expected to grow up to $467 billion in 2030 (Hafner et al., 2016). Furthermore, in 2015, the American Association of Sleep Medicine (AASM) reported that obstructive sleep apnea (OSA), one of the most prevalent sleep disorders, afflicted 12% of the adult population in the United States. AASM also noted that around 80% of people with OSA were undiagnosed, resulting in an economic burden of $149.6 billion due to loss in productivity and an increase in the risk of costly comorbidities (Watson, 2016). Despite their prevalen...

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