An ultra-sensitive label-free electrochemiluminescence CKMB immunosensor using a novel nanocomposite-modified printed electrode

Adhikari, Juthi; Keasberry, Natasha Ann; Mahadi, Abdul Hanif; Yoshikawa, Hiroyuki; Tamiya, Eiichi; Ahmed, Minhaz Uddin

doi:10.1039/c9ra05016g

Cited by 23 publications

(12 citation statements)

References 35 publications

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“…Accordingly, studies have been focused on developing rapid, reliable, and cost-effective tests for the detection of serum cardiac biomarkers with improved detection limits and accuracy. Most studies adopt metal-based NPs for the detection of CK-MB serum levels and only a few modified the surface of these NPs with polymers such as chitosan, dextran, and poly (maleic anhydride-alt-1-octadecene) due to their good adhesion quality and high permeability [ [131] , [132] , [133] ]. Alternatively, Lai et al.…”

Section: Polymeric Nps For the Diagnosis Of MImentioning

confidence: 99%

Polymeric nanoparticles in the diagnosis and treatment of myocardial infarction: Challenges and future prospects

Karam

Fahs

Maatouk

et al. 2022

Materials Today Bio

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Section: Polymeric Nps For the Diagnosis Of MImentioning

confidence: 99%

Polymeric nanoparticles in the diagnosis and treatment of myocardial infarction: Challenges and future prospects

Karam

Fahs

Maatouk

et al. 2022

Materials Today Bio

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“…B) Schematic for the fabrication of the label-free ECL CK-MB immunosensor based on an CNOS/Fe 3 O 4 /AuNPs/CS modified SPE. Reproduced and adapted with permission from ref [ 213 ]. Copyright Royal Society of Chemistry 2019.…”

Section: Current Electrochemical/electroanalytical Approaches To Dete...mentioning

confidence: 99%

“…Adhikari and colleagues developed an ultra-sensitive label-free electrochemiluminescence (ECL) CK-MB immunosensor using a whole range of nanocomposite-modified single-walled carbon nanotube (SWCNT)-screen-printed electrodes (SPE) [ 213 ]. Figure 5B shows the schematic representation of the fabrication steps involved.…”

Section: Current Electrochemical/electroanalytical Approaches To Dete...mentioning

confidence: 99%

Electroanalytical point-of-care detection of gold standard and emerging cardiac biomarkers for stratification and monitoring in intensive care medicine - a review

et al. 2022

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Determination of specific cardiac biomarkers (CBs) during the diagnosis and management of adverse cardiovascular events such as acute myocardial infarction (AMI) has become commonplace in emergency department (ED), cardiology and many other ward settings. Cardiac troponins (cTnT and cTnI) and natriuretic peptides (BNP and NT-pro-BNP) are the preferred biomarkers in clinical practice for the diagnostic workup of AMI, acute coronary syndrome (ACS) and other types of myocardial ischaemia and heart failure (HF), while the roles and possible clinical applications of several other potential biomarkers continue to be evaluated and are the subject of several comprehensive reviews. The requirement for rapid, repeated testing of a small number of CBs in ED and cardiology patients has led to the development of point-of-care (PoC) technology to circumvent the need for remote and lengthy testing procedures in the hospital pathology laboratories. Electroanalytical sensing platforms have the potential to meet these requirements. This review aims firstly to reflect on the potential benefits of rapid CB testing in critically ill patients, a very distinct cohort of patients with deranged baseline levels of CBs. We summarise their source and clinical relevance and are the first to report the required analytical ranges for such technology to be of value in this patient cohort. Secondly, we review the current electrochemical approaches, including its sub-variants such as photoelectrochemical and electrochemiluminescence, for the determination of important CBs highlighting the various strategies used, namely the use of micro- and nanomaterials, to maximise the sensitivities and selectivities of such approaches. Finally, we consider the challenges that must be overcome to allow for the commercialisation of this technology and transition into intensive care medicine. Graphical abstract

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“…They fabricated a basal electrode using AuNPs and platinum nanowires that were deposited onto indium tin oxide-coated glass linked with 3-aminopropyl-trimethoxysilane. Besides, Adhikari et al (2019) presented an ultrasensitive labelfree ECL immunosensor for CK-MB detection using a novel nanocomposite-modified printed electrode. To fabricate this sensor, carbon nano-onions (CNOs)/Fe 3 O 4 /AuNP/chitosan (CS) nanocomposite was dropped in single-layered rolled-up carbon nanotubes (SWCNTs).…”

Section: Electrochemiluminescence (Ecl) Immunoassaymentioning

confidence: 99%

Nanoscale Technologies in Highly Sensitive Diagnosis of Cardiovascular Diseases

Shi

Yang

et al. 2020

Front. Bioeng. Biotechnol.

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Cardiovascular diseases (CVD) are the leading cause of death and morbidity in the world and are a major contributor to healthcare costs. Although enormous progress has been made in diagnosing CVD, there is an urgent need for more efficient early detection and the development of novel diagnostic tools. Currently, CVD diagnosis relies primarily on clinical symptoms based on molecular imaging (MOI) or biomarkers associated with CVDs. However, sensitivity, specificity, and accuracy of the assay are still challenging for early-stage CVDs. Nanomaterial platform has been identified as a promising candidate for improving the practical usage of diagnostic tools because of their unique physicochemical properties. In this review article, we introduced cardiac biomarkers and imaging techniques that are currently used for CVD diagnosis. We presented the applications of various nanotechnologies on diagnosis within cardiac immunoassays (CIAs) and molecular imaging. We also summarized and compared different cardiac immunoassays based on their sensitivities and working ranges of biomarkers.

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An ultra-sensitive label-free electrochemiluminescence CKMB immunosensor using a novel nanocomposite-modified printed electrode

Abstract: This study presents a novel and ultrasensitive electrochemiluminescence approach for the quantitative assessment of creatine kinase MB (CK-MB).

Cited by 23 publications

References 35 publications

Polymeric nanoparticles in the diagnosis and treatment of myocardial infarction: Challenges and future prospects

Polymeric nanoparticles in the diagnosis and treatment of myocardial infarction: Challenges and future prospects

Electroanalytical point-of-care detection of gold standard and emerging cardiac biomarkers for stratification and monitoring in intensive care medicine - a review

Nanoscale Technologies in Highly Sensitive Diagnosis of Cardiovascular Diseases

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