An ultra-stable bio-inspired bacteriochlorin analogue for hypoxia-tolerant photodynamic therapy

Wu, Meng-Si; Li, Yong

doi:10.1039/d0sc05525e

Cited by 39 publications

(25 citation statements)

References 56 publications

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“…It is known that photodynamic therapy (PDT) suffers from a key drawback associated with its oxygen-dependent nature, which limits its effective use against hypoxic tumors [ 64 , 65 ]. Many strategies have been explored to solve this problem and improving blood flow in tumors is one of them [ 64 ].…”

Section: Resultsmentioning

confidence: 99%

Aggregation-induced emission luminogens for highly effective microwave dynamic therapy

Pandey

Wang

et al. 2022

Bioactive Materials

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Aggregation-induced emission luminogens (AIEgens) exhibit efficient cytotoxic reactive oxygen species (ROS) generation capability and unique light-up features in the aggregated state, which have been well explored in image-guided photodynamic therapy (PDT). However, the limited penetration depth of light in tissue severely hinders AIEgens as a candidate for primary or adjunctive therapy for clinical applications. Coincidentally, microwaves (MWs) show a distinct advantage for deeper penetration depth in tissues than light. Herein, for the first time, we report AIEgen-mediated microwave dynamic therapy (MWDT) for cancer treatment. We found that two AIEgens ( TPEPy-I and TPEPy-PF6 ) served as a new type of microwave (MW) sensitizers to produce ROS, including singlet oxygen ( 1 O 2 ), resulting in efficient destructions of cancer cells. The results of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and live/dead assays reveal that the two AIEgens when activated by MW irradiation can effectively kill cancer cells with average IC-50 values of 2.73 and 3.22 μM, respectively. Overall, the ability of the two AIEgens to be activated by MW not only overcomes the limitations of conventional PDT, but also helps to improve existing MW ablation therapy by reducing the MW dose required to achieve the same therapeutic outcome, thus reducing the occurrence of side-effects of MW radiation.

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Section: Resultsmentioning

confidence: 99%

Aggregation-induced emission luminogens for highly effective microwave dynamic therapy

Pandey

Wang

et al. 2022

Bioactive Materials

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“…NIR absorption photosensitizer FBC was firstly synthesized according to our previous work (Fig. S1, ESI †) 26 . Then, iodine-containing monomer 2-iodoethyl methacrylate was prepared via the esterification reaction between methacryloyl chloride and 2iodoethanol (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…S1, ESI † ). 26 Then, iodine-containing monomer 2-iodoethyl methacrylate was prepared via an esterification reaction between methacryloyl chloride and 2-iodoethanol (Fig. S2, ESI † ).…”

Section: Resultsmentioning

confidence: 99%

“…21,22 Recently, hypoxic-tolerance photosensitizers have provided a powerful tool for hypoxic tumor treatment. [23][24][25][26] These photosensitizers could produce toxic reactive oxygen species (ROS) such as superoxide (O 2 •-), hydroxyl (OH•) and hydroperoxyl (HO 2 • ) through photo-induced electron transfer mechanism. However, the produced toxic species are related to oxygen, indicating that the photodynamic therapeutic efficiency of these photosensitizers still relies on oxygen concentration although they require much lower oxygen concentration than traditional photosensitizers.…”

Section: Introductionmentioning

confidence: 99%

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Boosting cancer therapy efficiency via photoinduced radical production

Lan

2021

Chem. Sci.

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“…For example, the inherent defects of most O 2 −• photogenerators, such as short maximum absorption wavelength (less than 750 nm) and poor photo/chemical stability, would limit the therapeutic efficacy against deep tumors [34,35]. Moreover, normal nonplanar O 2 −• photogenerators tend to aggregate in physiological environments which might induce the quenching of O 2 −• [36,37].…”

Section: −•mentioning

confidence: 99%

NIR-absorbing superoxide radical and hyperthermia photogenerator via twisted donor-acceptor-donor molecular rotation for hypoxic tumor eradication

Zhu

Chen

et al. 2021

Sci. China Mater.

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Hypoxia severely impedes the therapeutic efficacies of tumor chemotherapy, radiotherapy and conventional photodynamic therapy (type II PDT). Herein, we proposed a nonplanar near-infrared (NIR)-absorbing hyperthermia and superoxide radical (O 2 −• ) photogenerator (TB) against hypoxic tumors. TB particularly possessed a favorable O 2 −• generation capability under 808 nm laser irradiation with the donoracceptor-donor (D-A-D) molecular structure. Moreover, owing to molecular rotation, potent hyperthermia was realized under continuous laser irradiation. For the usage of hypoxic tumor treatment, TB was encapsulated by a block copolymer, poly(ethylene glycol)-b-poly(latic acid) (PEG 45 -b-PLA 24 ), to fabricate phototheranostic nanoparticles (TB NPs). Due to the twisted molecular structure and the shielding effect of long alkyl chains, the π-π stacking-induced quenching of O 2 −• could be reduced after the fabrication of nano-assemblies. Significantly, TB NPs exhibited satisfactory O 2 −• generation for type I PDT and a simultaneously distinct photothermal conversion efficiency (PCE, 62%) for photothermal therapy (PTT) to combat hypoxic tumor cells. Moreover, the high PCE endowed TB NPs with high-performance photoacoustic (PA) and photothermal imaging capability.In vivo experiments demonstrated that TB NPs possessed an outstanding phototherapeutic efficacy for eradicating hypoxic tumors. This study established a novel approach for constructing oxygenindependent phototherapeutic reagent against hypoxic tumors.

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An ultra-stable bio-inspired bacteriochlorin analogue for hypoxia-tolerant photodynamic therapy

Abstract: Photodynamic therapy (PDT) greatly suffers from the weak NIR-absorption, oxygen dependence and poor stability of photosensitizers (PSs). Herein, inspired by natural bacteriochlorin, we develop a bacteriochlorin analogue, tetrafluorophenyl bacteriochlorin (FBC),...

Cited by 39 publications

References 56 publications

Aggregation-induced emission luminogens for highly effective microwave dynamic therapy

Aggregation-induced emission luminogens for highly effective microwave dynamic therapy

Boosting cancer therapy efficiency via photoinduced radical production

NIR-absorbing superoxide radical and hyperthermia photogenerator via twisted donor-acceptor-donor molecular rotation for hypoxic tumor eradication

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