An ultrasensitive detection of miRNA-155 in breast cancer via direct hybridization assay using two-dimensional molybdenum disulfide field-effect transistor biosensor

Majd, Samira Mansouri; Salimi, Abdollah; Ghasemi, Foad

doi:10.1016/j.bios.2018.01.009

Cited by 132 publications

(65 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both (2D)MoS 2 and IF-MoS 2 have huge prospects of wide application in biomedicine. Sensitive biosensors based on nanosized MoS 2 could serve as a diagnostic tool for cancer, detecting biomarkers like the prostate specific antigen (PSA) for prostate cancer or breast cancer miRNA [24,25], along with other molecules playing an higher efficiency. In addition, MoOxNPs are used in electrochemical capacitors, coatings, nanowires, nanofibers, plastics and textiles, in specific applications of alloys and catalysts, as oxidation catalysts, cracking catalysts, hydrogenation catalysts and pigments (similar to Mo itself), in ceramics and glass production, and as a raw material for the production of molybdenum metal [12].…”

Section: Applications Of Molybdenum and Its Compounds In Nanosized Fomentioning

confidence: 99%

Biological effects of molybdenum compounds in nanosized forms under in vitro and in vivo conditions

Sobańska¹,

Zapór²,

Szparaga³

et al. 2020

Int J Occup Med Environ Health

View full text Add to dashboard Cite

Nanoparticles of transition metal dichalcogenides, particularly of molybdenum (Mo), have gained a lot of focus due to their exceptional physicochemical properties and the growing number of technological applications. These nanoparticles are also considered as potential therapeutic tools, biosensors or drug carriers. It is crucial to thoroughly examine their biocompatibility and ensure safe usage. The aim of this review is to analyze the available data on the biological effects of different nanoforms of elemental Mo and its compounds. In the reviewed publications, different conditions were described, including different experimental models, examined nanoforms, and their used concentrations. Due to these differences, the results are rather difficult to compare. Various studies classify Mo related nanomaterials as very toxic, mildly toxic or non-toxic. Similarly, the mechanisms of toxicity proposed in some studies are different, including oxidative stress induction, physical membrane disruption or DNA damage. Quite promising, however, are the potential medical applications of MoS 2 nanoparticles in therapy of cancer and Alzheimer's disease. Further studies on biocompatibility of nanomaterials based on Mo compounds are warranted.

show abstract

Section: Applications Of Molybdenum and Its Compounds In Nanosized Fomentioning

confidence: 99%

Biological effects of molybdenum compounds in nanosized forms under in vitro and in vivo conditions

Sobańska¹,

Zapór²,

Szparaga³

et al. 2020

Int J Occup Med Environ Health

View full text Add to dashboard Cite

show abstract

“…Sensing strategies and devices for microorganism have been reported based on different principles and TMDC-based FET has recently become newly emerged sensing platform for microorganisms. The reports of TMDC FET sensors for the detection of various biomolecules including proteins [31,32,81,[134][135][136][137][138][139][140][141][142][143] and nucleic acids (DNA/RNA) [26][27][28][29][144][145][146][147][148][149] TiO 2 FETs [150], in which vancomycin with bio-affinity to S. aureus was functionalized onto MoS 2 via a TiO 2 layer, contributing to the efficient discriminating ability of the sensor between Gram-positive and Gram-negative bacteria. The detection of Ebola, a lethal virus, was achieved with FET sensors with liquid-phase exfoliated MoS 2 [151], in which selective detection relied on the bio-recognition of a specific protein VP40 antigen on Ebola.…”

Section: Detection Of Microorganismsmentioning

confidence: 99%

“…As the representative TMDC, MoS 2 shows a high carrier mobility (60 cm 2 /V s at 250 K), a layer-dependent bandgap (1.2-1.8 eV), a high transistor on/off ratio (~ 10 8 ), and reasonable environmental stability [11]. Recent reports have demonstrated that 2D MoS 2 is a desirable channel material in FET sensor with breakthroughs in sensing performance for various analytes including NO 2 [12][13][14][15], NH 3 [16,17], chemical vapor [18,19], metal ion [20][21][22], small molecule [23][24][25], as well as biomaterials such as nucleic acid [26][27][28][29], protein [30][31][32], and microorganism [33]. Compared with MOSFET sensors, 2D-TMDCbased FET sensors normally show higher sensitivities due to the 2D nanosheet structure of TMDC.…”

Section: Introductionmentioning

confidence: 99%

Environmental Analysis with 2D Transition-Metal Dichalcogenide-Based Field-Effect Transistors

2020

View full text Add to dashboard Cite

• Recent advances of two-dimensional (2D) transition-metal dichalcogenide (TMDC)-based field-effect transistor (FET) sensors for environmental analysis are summarized. • Representative TMDC FET sensors in gaseous and aqueous media analysis are introduced. • Challenges and future research directions of 2D TMDC FET sensors are discussed. ABSTRACT Field-effect transistors (FETs) present highly sensitive, rapid, and in situ detection capability in chemical and biological analysis. Recently, two-dimensional (2D) transition-metal dichalcogenides (TMDCs) attract significant attention as FET channel due to their unique structures and outstanding properties. With the booming of studies on TMDC FETs, we aim to give a timely review on TMDCbased FET sensors for environmental analysis in different media. First, theoretical basics on TMDC and FET sensor are introduced. Then, recent advances of TMDC FET sensor for pollutant detection in gaseous and aqueous media are, respectively, discussed. At last, future perspectives and challenges in practical application and commercialization are given for TMDC FET sensors. This article provides an overview on TMDC sensors for a wide variety of analytes with an emphasize on the increasing demand of advanced sensing technologies in environmental analysis.

show abstract

“…Majd et al [ 39 ] developed a MoS 2 -FET biosensor for the label-free detection of a breast cancer biomarker, miRNA-155, in cell lines and human serum. The MoS 2 flakes, as the channel sensing material used in this work, were prepared using the sequential solvent exchange method, and drop-casted onto the FET surface.…”

Section: Non-carbon 2d Materialsmentioning

confidence: 99%

Non-Carbon 2D Materials-Based Field-Effect Transistor Biosensors: Recent Advances, Challenges, and Future Perspectives

Sedki

Chen

Mulchandani

2020

Sensors

View full text Add to dashboard Cite

In recent years, field-effect transistors (FETs) have been very promising for biosensor applications due to their high sensitivity, real-time applicability, scalability, and prospect of integrating measurement system on a chip. Non-carbon 2D materials, such as transition metal dichalcogenides (TMDCs), hexagonal boron nitride (h-BN), black phosphorus (BP), and metal oxides, are a group of new materials that have a huge potential in FET biosensor applications. In this work, we review the recent advances and remarkable studies of non-carbon 2D materials, in terms of their structures, preparations, properties and FET biosensor applications. We will also discuss the challenges facing non-carbon 2D materials-FET biosensors and their future perspectives.

show abstract

An ultrasensitive detection of miRNA-155 in breast cancer via direct hybridization assay using two-dimensional molybdenum disulfide field-effect transistor biosensor

Cited by 132 publications

References 49 publications

Biological effects of molybdenum compounds in nanosized forms under <i>in vitro</i> and <i>in vivo</i> conditions

Biological effects of molybdenum compounds in nanosized forms under <i>in vitro</i> and <i>in vivo</i> conditions

Environmental Analysis with 2D Transition-Metal Dichalcogenide-Based Field-Effect Transistors

Non-Carbon 2D Materials-Based Field-Effect Transistor Biosensors: Recent Advances, Challenges, and Future Perspectives

Contact Info

Product

Resources

About