2015
DOI: 10.1016/j.bios.2015.05.015
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An ultrasensitive DNA biosensor based on covalent immobilization of probe DNA on fern leaf-like α-Fe2O3 and chitosan Hybrid film using terephthalaldehyde as arm-linker

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Cited by 36 publications
(10 citation statements)
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“…This result shows that the loading amount of pDNA on pTyr/SnO 2 −C/GCE is about threefold larger than that on pTyr/GCE, revealing that the SnO 2 −C nanocomposite plays a vital role to increase the loading amount of the pDNA by its surface area effect. Such a high surface density of pDNA is also higher than the previously reported DNA biosensors such as 8.83 × 10 12 strands cm −2 on TPA/CS-Fe 2 O 3 33 and 1.05 × 10 13 strands cm −2 on gold nanoparticles. 34 What is more, the probe electrode was interacted with excess amount of tDNA, and the DNA strands on the hybridized electrode were also measured by CC in RuHex solution; the ΔQ of 2.40 μC and the DNA density of 8.33 × 10 13 strands cm −2 were estimated, respectively.…”
Section: Resultsmentioning
confidence: 61%
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“…This result shows that the loading amount of pDNA on pTyr/SnO 2 −C/GCE is about threefold larger than that on pTyr/GCE, revealing that the SnO 2 −C nanocomposite plays a vital role to increase the loading amount of the pDNA by its surface area effect. Such a high surface density of pDNA is also higher than the previously reported DNA biosensors such as 8.83 × 10 12 strands cm −2 on TPA/CS-Fe 2 O 3 33 and 1.05 × 10 13 strands cm −2 on gold nanoparticles. 34 What is more, the probe electrode was interacted with excess amount of tDNA, and the DNA strands on the hybridized electrode were also measured by CC in RuHex solution; the ΔQ of 2.40 μC and the DNA density of 8.33 × 10 13 strands cm −2 were estimated, respectively.…”
Section: Resultsmentioning
confidence: 61%
“…This result shows that the loading amount of pDNA on pTyr/SnO 2 –C/GCE is about threefold larger than that on pTyr/GCE, revealing that the SnO 2 –C nanocomposite plays a vital role to increase the loading amount of the pDNA by its surface area effect. Such a high surface density of pDNA is also higher than the previously reported DNA biosensors such as 8.83 × 10 12 strands cm –2 on TPA/CS-Fe 2 O 3 and 1.05 × 10 13 strands cm –2 on gold nanoparticles …”
Section: Resultsmentioning
confidence: 65%
“…Hence, it is important to rationally couple the α-Fe 2 O 3 nanoleaves with other nanomaterials to form a novel hybrid structure which can reveal enhanced electrochemical activity. There have been recent reports on hybrid α-Fe 2 O 3 composites such as graphene oxide-α-Fe 2 O 3 , MWCNT-α-Fe 2 O 3 , chitosan-α-Fe 2 O 3 -terephthalaldehyde, and carbon nitride-α-Fe 2 O 3 used for electrochemical sensing of hydroquinone, ascorbic acid, DNA, and glucose, respectively. Meanwhile, reduced graphene oxide-Fe 2 O 3 , N -RGO-Fe 2 O 3 , and single-crystalline Fe 2 O 3 particles/graphene modified composites were reported for supercapacitor applications. To the best of our knowledge, this is the first report on an α-Fe 2 O 3 nanoleaf-decorated MPC-chit modified composite for two different potential applications: selective electrochemical sensing of nitrite at neutral pH and high-performance supercapacitor applications at alkaline pH. Recently, mesoporous carbon has attracted much attention as a host material for metals, metal oxides, and polymers for electrochemical sensors and energy storage applications. The high surface area, good electrical conductivity, a well-defined, large pore volume, and the unique features resulting from combining biopolymer chitosan enable higher α-Fe 2 O 3 nanoleaf incorporation for improved electrocatalytic activity of nitrite and supercapacitor applications.…”
Section: Introductionmentioning
confidence: 99%
“…The association of magnetic nanoparticles with organic materials allowed the improvement of the transducing platform for E-DNA biosensors. For example, associations of Fe 2 O 3 with chitosan (Xu et al, 2015), or chitosan-graphene (Tiwari et al, 2015), were employed as platforms for E-DNA sensing by measuring the DNA hybridization through the redox signal of external ferrocyanide markers.…”
Section: Introductionmentioning
confidence: 99%