An ultrasensitive electrochemical biosensor for bisphenol A based on aptamer-modified MrGO@AuNPs and ssDNA-functionalized AuNP@MBs synergistic amplification

Hu, Liu-Yin; Cui, Jiahua; Wang, Yalin; Jia, Jinping

doi:10.1016/j.chemosphere.2022.137154

Cited by 17 publications

(3 citation statements)

References 51 publications

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“…The biosensor displayed good sensitivity under optimal conditions, with a detection limit as low as 0.141 pg/mL. The design consisted of a combination of BPA aptamer-MrGO@AuNPs and methylene blue-loaded gold nanoparticles to form a stable complex for synergistic signal amplification [105].…”

Section: Gold (Au)mentioning

confidence: 99%

Synthesis and Modification of Magnetic Nanoparticles for Biosensing and Bioassay Applications: A Review

Carinelli,

Luis-Sunga,

González-Mora

et al. 2023

Chemosensors

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Biosensors are analytical devices that use biological interactions to detect and quantify single molecules, clinical biomarkers, contaminants, allergens, and microorganisms. By coupling bioreceptors with transducers, such as nucleic acids or proteins, biosensors convert biological interactions into electrical signals. Electrochemical and optical transductions are the most widely used methods due to their high detection capability and compatibility with miniaturization. Biosensors are valuable in analytical chemistry, especially for health diagnostics, as they offer simplicity and sensitivity. Despite their usefulness, challenges persist in immobilizing biorecognition elements on the transducer surface, leading to issues such as loss of sensitivity and selectivity. To address these problems, the introduction of nanomaterials, in particular magnetic nanoparticles (MNPs) and magnetic beads, has been implemented. MNPs combine their magnetic properties with other interesting characteristics, such as their small size, high surface-to-volume ratio, easy handling, and excellent biocompatibility, resulting in improved specificity and sensitivity and reduced matrix effects. They can be tailored to specific applications and have been extensively used in various fields, including biosensing and clinical diagnosis. In addition, MNPs simplify sample preparation by isolating the target analytes via magnetic separation, thus reducing the analysis time and interference phenomena and improving the analytical performance of detection. The synthesis and modification of MNPs play a crucial role in adjusting their properties for different applications. This review presents an overview of the synthesis and surface modifications of magnetic nanoparticles and their contributions to the development of biosensors and bioassays for their applications across different areas. The future challenges of MNP synthesis and integration in assays are focused on their stability, multiplex detection, simplification and portability of test platforms, and in vivo applications, among other areas of development.

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Section: Gold (Au)mentioning

confidence: 99%

Synthesis and Modification of Magnetic Nanoparticles for Biosensing and Bioassay Applications: A Review

Carinelli,

Luis-Sunga,

González-Mora

et al. 2023

Chemosensors

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“…With the development of nanotechnology, various biosensors and drug delivery systems constructed on gold nanoparticle (AuNP) substrates have become practical tools. [13][14][15] For example, Hong and co-workers 16 developed a biosensor that exploits the competition between AuNPs and microRNAs to bind to capture probes immobilized on the AuNP surface, thereby enhancing the sensitivity of detection. Hou and his colleagues 17 reported a phage-based surface plasmon resonance (P-SPR) strategy for detecting carcinoembryonic antigens (CEAs) in undiluted serum samples.…”

Section: Introductionmentioning

confidence: 99%

Plasmonic nanoprobes on single AuNTs for evaluating and monitoring the dynamic release of 2D drug carriers

Yu,

Wang,

Cai

et al. 2023

J. Mater. Chem. B

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“…Point of use sensors are the next best solutions for rapid screening of compounds such as BPA. Most of these technologies use a biorecognition element such as whole cells [6], polynucleotides [7] or enzymes [8], most of which have very specific physiochemical stability criteria for which they are tested. These coupled with complex transduction techniques [9] are often reported to potentially compete with the chromatography coupled mass spectroscopic techniques [10] in terms of sensitivity, accuracy and detection limits.…”

mentioning

confidence: 99%

In Situ Synthesis of Plasmonic Core MIPs on U Bend Optical Fibers for LSPR Sensing of Small Molecule Contaminants in Food and Environment: An Illustration With Bisphenol A

Nag,

Sadani,

Mukherji

et al. 2024

IEEE Sensors J.

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Detection and remediation of emerging water contaminants such as active pharmaceutical ingredients, endocrine disrupting compounds and polyaromatic hydrocarbons is a global challenge. The current study reports a label free and biorecognition element free detection strategy for detection of such organic compounds in aqueous specimen with Bisphenol A (BPA) as a model analyte. A novel in situ molecular imprinting technique on gold nanoparticles (AuNPs), immobilized on U bend optical fibers is demonstrated for localized surface plasmon sensing. The molecularly imprinted polymer film was directly formed on allyl mercaptan modified gold nanoparticles. With an optimized ratio of 1:12:20 of template: monomer: crosslinker, the sensor could detect BPA in the linear range from 30 ng/mL to 10 µg/mL (R 2 =0.95) in deionized water and from 50 ng/mL to 50 µg/mL (R 2 =0.96) in bottled and canned soft, alcoholic and aerated beverages, fruit juices and ice tea with negligible cross sensitivity from possible interferents. This technology is thus of utility to analyze BPA, and similar organic molecules in wastewater, food and beverages and indicate the fitness of food and water for human consumption.

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An ultrasensitive electrochemical biosensor for bisphenol A based on aptamer-modified MrGO@AuNPs and ssDNA-functionalized AuNP@MBs synergistic amplification

Cited by 17 publications

References 51 publications

Synthesis and Modification of Magnetic Nanoparticles for Biosensing and Bioassay Applications: A Review

Synthesis and Modification of Magnetic Nanoparticles for Biosensing and Bioassay Applications: A Review

Plasmonic nanoprobes on single AuNTs for evaluating and monitoring the dynamic release of 2D drug carriers

In Situ Synthesis of Plasmonic Core MIPs on U Bend Optical Fibers for LSPR Sensing of Small Molecule Contaminants in Food and Environment: An Illustration With Bisphenol A

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