An ultrasensitive FRET-based fluorescent low molecular weight heparin nanoprobe for quantifying heparanase activity

Gu, Yayun; Peng, Lizhong; Ding, Weihua; Wang, Yan; Zeng, Xuhui

doi:10.1016/j.talanta.2022.124207

Cited by 4 publications

(2 citation statements)

References 52 publications

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“…Terbium ion-carbon dots Quantitative monitoring of ATP [202] Molecularly imprinted polymer-carbon dots Evaluation of AChE activity and screening its inhibitors [203] CdSeTe QDs-fibrils nanocrystals Screening drugs for modulating the prion-like transmission [204] CuFeS 2 QDs Detection of cyclin D1 for screening anticancer drugs [205] Monomeric graphene QDs Determination of the ifosfamide level in biological samples [206] FITC-peptide-graphene oxide Determination of BACE1 activity and screening its inhibitors [207] Tb 3+ or Eu 3+ probes Time-gated luminescence detection of H 2 S [208] MnO 2 -nanosheet-modified UCNPs Rapid screening of glutathione molecules in aqueous solutions [209] CoOOH-functionalized UCNPs Quantitative analysis of ascorbic acid [210] Two-photon dye-doped silica NPs Bioimaging of endogenous ATP for drug screening [59] Graphene oxide-fluorescent system High-throughput screening of novel antiviral compounds [211] AuNCs-LMWH-AuNRs High throughput screening of heparinase inhibitors [212] Diphenylalanine peptide-AuNCs Screening anti-amyloid drugs [64] Chromophore-AuNCs Screening drug-induced nephrotoxicity [69] instrumental analytical techniques, such as high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE), to achieve more economical, operational, and sensitive detection or quantification. [18] Besides, based on rational design and engineering, some commonly used nanoprobes, like QDs and carbon dots (CDs), enable chiral discrimination of drugs.…”

Section: Luminescence Nanoprobes Applications Referencesmentioning

confidence: 99%

Luminescence Nanoprobes for Drug Screening, Pharmaceutical Analysis, and Therapeutic Evaluations

Guo

et al. 2023

Advanced Sensor Research

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Luminescence nanoprobes have been extensively investigated for many biomedical applications, ranging from cell/tissue imaging, real‐time monitoring pathophysiological changes, drug discovery, bioassays, image‐guided surgery, and therapeutic evaluations, mainly due to their excellent physicochemical properties such as tailorable size, controlled morphology, and regulatable luminescence performances. In particular, rationally designed luminescence nanoprobes with reasonable functional integration enable pharmacological effect‐based drug screening, quantification of biological/pharmaceutical agents, and monitoring therapeutic responses of different drugs. This review provides an overview of the applications of different types of luminescence nanoprobes in drug discovery and development, involving various nanoprobes for high‐throughput and high‐content drug screening, pharmaceutical analysis, and therapeutic evaluations in cancers, cardiovascular diseases, and other typical inflammatory diseases. Moreover, challenges and future perspectives regarding future applications of luminescence nanoprobes in the drug discovery field are also discussed.

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Section: Luminescence Nanoprobes Applications Referencesmentioning

confidence: 99%

Luminescence Nanoprobes for Drug Screening, Pharmaceutical Analysis, and Therapeutic Evaluations

Guo

et al. 2023

Advanced Sensor Research

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“…3 The whole immune process is assembled on a membrane, which has the advantages of simple operation, low detection cost, short reaction time and long shelf life. [4][5][6] Therefore, LFIA is widely used in food safety detection, [7][8][9][10] water quality monitoring, 11,12 medical diagnosis [13][14][15][16] and other elds. LFIA usually employs labeled particles to present signals.…”

Section: Introductionmentioning

confidence: 99%

Preparation of dyed polymer microspheres by a physical–chemical dual-binding method and their application in lateral flow immunoassay

Li,

Zhang,

et al. 2024

Anal. Methods

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A Semi‐Automatic Environmental Monitoring Device for Mercury and Cobalt Ion Detection

Chiou,

Pang,

Huang

et al. 2023

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A syringe‐based, semi‐automatic environmental monitoring device is developed for on‐site detection of harmful heavy metal ions in water. This portable device consists of a spring‐embedded syringe and a polydimethylsiloxane (PDMS) membrane‐based flow regulator for semi‐automatic fix‐and‐release fluidic valve actuation, and a paper‐based analytical device (PAD) with two kinds of gold nanoclusters (AuNCs) for sensitive Hg2+ and Co2+ ion detection, respectively. The thickness of the elastic PDMS membrane can be adjusted to stabilize and modulate the flow rates generated by the pushing force provided by the spring attached to the plunger. Also, different spring constants can drastically alter the response time. People of all ages can extract the fix‐volume sample solutions and then release them to automatically complete the detection process, ensuring high reliability and repeatability. The PAD comprises two layers of modified paper, and each layer is immobilized with bovine serum albumin‐capped gold nanoclusters (R‐AuNCs) and glutathione‐capped gold clusters (G‐AuNCs), respectively. The ligands functionalized on the surface of the AuNCs not only can fine‐tune the optical properties of the nanoclusters but also enable specific and simultaneous detection of Hg2+ and Co2+ ions via metallophilic Au+–Hg2+ interaction and the Co2+–thiol complexation effect, respectively. The feasibility of the device for detecting heavy metal ions at low concentrations in various environmental water samples is demonstrated. The Hg2+ and Co2+ ions can be seen simultaneously within 20 min with detection limits as low as 1.76 nm and 0.27 µm, respectively, lower than those of the regulatory restrictions on water by the US Environmental Protection Agency and the European Union. we expect this sensitive, selective, portable, and easy‐to‐use device to be valid for on‐site multiple heavy metal ion pollution screenings in resource‐constrained settings.

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An ultrasensitive FRET-based fluorescent low molecular weight heparin nanoprobe for quantifying heparanase activity

Cited by 4 publications

References 52 publications

Luminescence Nanoprobes for Drug Screening, Pharmaceutical Analysis, and Therapeutic Evaluations

Luminescence Nanoprobes for Drug Screening, Pharmaceutical Analysis, and Therapeutic Evaluations

Preparation of dyed polymer microspheres by a physical–chemical dual-binding method and their application in lateral flow immunoassay

A Semi‐Automatic Environmental Monitoring Device for Mercury and Cobalt Ion Detection

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