2023
DOI: 10.1016/j.bioorg.2023.106454
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An ultrasensitive GSH-specific fluorescent probe unveils celastrol-induced ccRCC ferroptosis

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Cited by 10 publications
(8 citation statements)
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“…GSH is the main reducing agent in biochemical processes and is the most abundant thiol compound in the cytoplasm. 35 As shown in Figure S1C, S. putrefaciens in the pure CO 2 group exhibited a declined trend of GSH, and GSH values in the CO 2 group were approximately 9.37−42.78% lower than those in the air group. In accordance with Wang et al, 36 the declined trend could be attributed to the consumption of GSH by the increase of H 2 O 2 , which could be evidenced by the gradual higher levels of H 2 O 2 , as shown in Figure S1A.…”
Section: T-aoc and The Concentration Of Gshmentioning
confidence: 84%
“…GSH is the main reducing agent in biochemical processes and is the most abundant thiol compound in the cytoplasm. 35 As shown in Figure S1C, S. putrefaciens in the pure CO 2 group exhibited a declined trend of GSH, and GSH values in the CO 2 group were approximately 9.37−42.78% lower than those in the air group. In accordance with Wang et al, 36 the declined trend could be attributed to the consumption of GSH by the increase of H 2 O 2 , which could be evidenced by the gradual higher levels of H 2 O 2 , as shown in Figure S1A.…”
Section: T-aoc and The Concentration Of Gshmentioning
confidence: 84%
“…(a) Detection of GSH and ferroptosis monitoring with an ultrasensitive GSH-specific fluorescent probe. Reprinted with permission from ref . Copyright 2023, Elsevier.…”
Section: Detection Of Ferroptosis and Probe Assisted Cancer Therapymentioning
confidence: 99%
“…Following the administration of celastrol, a significant decrease in the GSH level was observed both in vitro and in vivo. 204 Using 2-(2′-Hydroxyphenyl) benzothiazole (HBT) as the fluorophore, another GSH sensitive probe designated BTFMD (Probe 19) was developed. 205 2,4-Dinitrobenzenesulfonate moiety was chosen as the reactive site, which could be rapidly cleaved to generate BTFM−OH in the presence of GSH, Cys, and homocysteine.…”
Section: Therapeutic Monitoring and Interventions 4211 Gsh/gpx4mentioning
confidence: 99%
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“…However, these classic modalities are unable to realize noninvasive and real-time imaging of variations of biomolecules and pathophysiological microenvironments. With the development of fluorescence sensing technology in recent years, fluorescence probes have been applied to track ferroptosis because of their noninvasiveness, high analytical sensitivity, and great spatiotemporal resolution. GSH as reducing substance is considered to be the key biomarker to directly monitor ferroptosis because ferroptosis can be regulated by the system X c – /GSH/GPX4 by controlling the generation of phospholipid hydroperoxides. , However, using the current GSH probe for the study of ferroptosis faced the following limitations: (1) The majority of GSH probes were designed based on irreversible response mechanisms, which were unsuitable for the real-time monitoring of GSH dynamics in living cells. (2) It is evident that single-target analysis still suffers from potential “false positive” signals in complicated physiological and pathological processes. (3) The current work mostly focused on the classic system X c – /GSH/GPX4 axis by monitoring GSH in the cytoplasm, leaving other non-GPX4 pathways, such as the DHODH-mediated ferroptosis defense mechanism unexplored.…”
Section: Introductionmentioning
confidence: 99%