An ultrasensitive lipid droplet-targeted NIR emission fluorescent probe for polarity detection and its application in liver disease diagnosis

Abstract

Compared to the normal cells, the diseased cells require more energy supply during proliferation and metabolism. In living cells, in addition to mitochondria, lipid droplets are also important organelles for...

Small-molecule fluorescent probes for bioactive species in inflammatory disease: arthritis, pneumonia and hepatitis

“…28A) for polarity detection based on ICT mechanism. 91 The probe had a dimethylaminophenyl group on one side and a difluoroboronated β-diketone conjugated coumarin on the other side, which formed a donor–acceptor structure. The composed conjugated system and push–pull electronic system endowed the probe with ultrasensitive polarity sensitivity, excellent chemical stability and photostability.…”

A Lipid Droplet-Specific NIR Fluorescent Probe with a Large Stokes Shift for In Vivo Visualization of Polarity in Contrast-Induced Acute Kidney Injury

“…Various physiological and pathological processes of living organisms are generally accompanied by alterations in the cellular microenvironment, for example, polarity, viscosity, and pH. , Polarity is a critical microenvironmental factor in biological systems because multiple complicated physiological and pathological processes including protein denaturation, enzymatic catalysis, peptide aggregation, membrane fusion, and signal transduction are critically dependent on balanced polarity. − The polarity changes in the cell, particularly subcellular changes, are associated with most pathology. Polarity is also significantly involved in cell apoptosis, migration, differentiation, and the activation of immune responses.…”

A fluorescent probe for lipid droplet polarity imaging with low viscosity crosstalk

“…There are fewer probes for sensing the changes of the lipid drop polarity. 13,14,[20][21][22][23][24]26,[28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] On the other hand, most of the probes as LD polarity indicators exhibit poor resistance to photobleaching. 21,26,34,43,44 This feature may significantly block their application in biosensing due to the fact that photostability is a pre-requisite for long-term tracking of analyte changes in living cells.…”