An ultrasensitive photoelectrochemical biosensor based on [Ru(dcbpy)2dppz]2+/Rose Bengal dyes co-sensitized fullerene for DNA detection

Wang, Haihua; Li, Mengjie; Zheng, Yingning; Hu, Tao; Yuan, Ruo

doi:10.1016/j.bios.2018.08.035

Cited by 30 publications

(16 citation statements)

References 39 publications

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“…30 As shown in Figure 1D, SiO 2 − COOH NPs with an average size of 40 nm had a spherical structure and showed well-dispersed NPs. 26 These results indicate the successful synthesis of nanomaterials.…”

Section: ■ Results and Discussionmentioning

confidence: 75%

“…Subsequently, the aforementioned solution was transferred to a Teflon-lined stainless-steel autoclave and then heated to 160 °C for 14 h. Finally, the obtained precipitate was purified by centrifugation and washing with ethanol and ultrapure water and then drying at 70 °C to obtain the CSZS–V Zn composite. SiO 2 –COOH NPs and Fe 3 O 4 @Au were synthesized following previously reported studies − with some improvements (details are provided in the Supporting Information).…”

Section: Experimental Sectionmentioning

confidence: 99%

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Ultrasensitive Photoelectrochemical Biosensor Based on Novel Z-Scheme Heterojunctions of Zn-Defective CdS/ZnS for MicroRNA Assay

et al. 2021

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The sensitive and accurate detection of microRNA (miRNA) has meaningful values for clinical diagnosis application as an early stage of tumor markers. Herein, a novel photoelectrochemical (PEC) biosensor was developed for the ultrasensitive and highly selective detection of microRNA-122 (miRNA-122) based on a direct Z-scheme heterojunction of Zn vacancy-mediated CdS/ZnS (CSZS− V Zn ). Impressively, the prepared Z-scheme heterojunction nanocomposite with defect level properties could make the photogenerated charges stay at the Zn vacancy defect levels and combine photogenerated holes in the valence bands of CdS, thus significantly achieving a better charge carrier separation efficiency and broadening the absorption of visible light and demonstrating 5−8 times enhancement of PEC response compared to single-component materials. Simultaneously, an exonuclease III (Exo-III)-assisted signal amplification strategy and a strand displacement reaction were combined to improve the conversion efficiency of the target and further increase the detection sensitivity. More importantly, the elaborated biosensor showed ultrasensitive and highly specific detection of the target miRNA-122 over a wide linear range from 10 aM to 100 pM with a low detection limit of 3.3 aM and exhibited enormous potential in the fields of bioanalysis and clinical diagnosis.

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Section: ■ Results and Discussionmentioning

confidence: 75%

Section: Experimental Sectionmentioning

confidence: 99%

Ultrasensitive Photoelectrochemical Biosensor Based on Novel Z-Scheme Heterojunctions of Zn-Defective CdS/ZnS for MicroRNA Assay

et al. 2021

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“…After that, 1 mM 5 μL HT was added to block remaining binding sites of AuNPs. 100 μL SiO 2 –NH 2 NPs prepared according to the previous report and dialdehyde solution were added into 10 μL 100 μM amino-labeled capture DNA for obtaining SiO 2 -labeled DNA linkers through 2 h cross-linking reaction at 37 °C. Finally, 5 μL SiO 2 -labeled DNA linkers were introduced to immobilize on GCE through hybridization with output DNA.…”

Section: Methodsmentioning

confidence: 99%

Novel D-A-D-Type Supramolecular Aggregates with High Photoelectric Activity for Construction of Ultrasensitive Photoelectrochemical Biosensor

et al. 2019

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In this work, hydrazine-functionalized perylene diimide derivative supramolecular (HPDS), a novel self-enhanced donor–acceptor-donor (D-A-D) type aggregates with excellent photoelectric activity, was synthesized by a facile one-pot green route and further applied in construction of coreactant-free photoelectrochemical (PEC) biosensor for ultrasensitive DNA assay. Impressively, the HPDS formed by D-A-D units not only possessed effectively shorted electron-transfer path between donor and acceptor, but also presented a desiring aggregate state via the π–π stacking of perylene core and hydrogen bonding of the terminal moiety, thereby acquiring a high density electron flow for generating the extremely high PEC signal. Experimental data showed that the well film-formed HPDS aggregate could produce an exciting photocurrent intensity about 6-fold stronger than that of precursor perylene dianhydride with donor N2H4 in detection buffer and even 12-fold than that of perylene dianhydride only. In this respect, the resultant HPDS aggregate as a novel self-enhanced PEC signal tag was adopted to fabricate the coreactant-free PEC biosensor with the help of target dual-recycling-induced bipedal DNA walker cascade amplification strategy for ultrasensitive DNA (a fragment of TP53 gene) assay. The proposed biosensor showed a high sensitivity with a low detection limit down to femtomole level, providing a new avenue for sensitive bioanalysis and clinical diagnosis.

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“…In the subsequent years, Li et al successfully detected fragments of the P53 gene (tumor suppressor gene) and Mycobacterium tuberculosis -specific DNA fragments by combining C 60 with wide-bandgap [Ru(Dcbpy) 2 dppz] 2+ /Rose Red dye, methylene blue, Co 3 O 4 , or directly preparing fullerenol C 60 (OH) 25 with high PEC signals in PEC sensors. These sensors have an excellent sensitivity (minimum detection concentration below 1 fM) and specificity [ [93] , [94] , [95] , [96] ]. Although PEC sensors are simple to use and relatively inexpensive, most of the current sensors based on CNs have complex modifications and biomolecular immobilization schemes.…”

Section: Biosensing Technologymentioning

confidence: 99%

Multifunctional carbon nanomaterials for diagnostic applications in infectious diseases and tumors

et al. 2022

Materials Today Bio

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An ultrasensitive photoelectrochemical biosensor based on [Ru(dcbpy)2dppz]2+/Rose Bengal dyes co-sensitized fullerene for DNA detection

Cited by 30 publications

References 39 publications

Ultrasensitive Photoelectrochemical Biosensor Based on Novel Z-Scheme Heterojunctions of Zn-Defective CdS/ZnS for MicroRNA Assay

Ultrasensitive Photoelectrochemical Biosensor Based on Novel Z-Scheme Heterojunctions of Zn-Defective CdS/ZnS for MicroRNA Assay

Novel D-A-D-Type Supramolecular Aggregates with High Photoelectric Activity for Construction of Ultrasensitive Photoelectrochemical Biosensor

Multifunctional carbon nanomaterials for diagnostic applications in infectious diseases and tumors

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