An ultrasound activated cyanine-rhenium(<scp>i</scp>) complex for sonodynamic and gas synergistic therapy

Zhu, Jiayi; Ouyang, Ai; He, Jiaming; Xie, Juan; Banerjee, Samya; Zhang, Qianling; Zhang, Pingyu

doi:10.1039/d1cc06769a

Cited by 32 publications

(52 citation statements)

References 33 publications

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“…Several recent studies have demonstrated the versatile therapeutic potential of nanomaterials that reveal induced-shear force as a sonodynamic effect causing LPO and ferroptosis. 41–44…”

Section: Ultrasoundmentioning

confidence: 99%

“…Several recent studies have demonstrated the versatile therapeutic potential of nanomaterials that reveal induced-shear force as a sonodynamic effect causing LPO and ferroptosis. [41][42][43][44] In 2021, Chen et al demonstrated synergistic tumor treatment via an SDT-based LPO mechanism to induce ferroptosis using ferumoxytol and a PpIX sonosensitizer (Fig. 4b).…”

Section: Sono-shear Force-mediated Cancer Therapymentioning

confidence: 99%

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Mechanical stimuli-driven cancer therapeutics

Hong

Won

et al. 2023

Chem. Soc. Rev.

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“…Several recent studies have demonstrated the versatile therapeutic potential of nanomaterials that reveal induced-shear force as a sonodynamic effect causing LPO and ferroptosis. 41–44…”

Section: Ultrasoundmentioning

confidence: 99%

Section: Sono-shear Force-mediated Cancer Therapymentioning

confidence: 99%

Mechanical stimuli-driven cancer therapeutics

Hong

Won

et al. 2023

Chem. Soc. Rev.

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“…To date, several gases, such as nitrogen (N 2 ), and nitric oxide (NO), carbon oxide (CO), carbon dioxide (CO 2 ), have been involved in these therapeutic approaches ( Chen et al, 2019 ). When SDT is combined with gas therapy for tumor treatment, the US triggers gas donors to release and produce highly toxic products or change the disease condition to promote the tumor suppression effects ( An et al, 2020b ; Cheng et al, 2022 ; Zhu et al, 2022 ; Zuo et al, 2022 ). The generated gas bubbles could be used as a powerful US contrast agent that greatly enhances the US contrast to guide cancer therapy.…”

Section: Sonodynamic Therapymentioning

confidence: 99%

The crosstalk between sonodynamic therapy and autophagy in cancer

et al. 2022

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As a noninvasive treatment approach for cancer and other diseases, sonodynamic therapy (SDT) has attracted extensive attention due to the deep penetration of ultrasound, good focusing, and selective irradiation sites. However, intrinsic limitations of traditional sonosensitizers hinder the widespread application of SDT. With the development of nanotechnology, nanoparticles as sonosensitizers or as a vehicle to deliver sonosensitizers have been designed and used to target tissues or tumor cells with high specificity and accuracy. Autophagy is a common metabolic alteration in both normal cells and tumor cells. When autophagy happens, a double-membrane autophagosome with sequestrated intracellular components is delivered and fused with lysosomes for degradation. Recycling these cell materials can promote survival under a variety of stress conditions. Numerous studies have revealed that both apoptosis and autophagy occur after SDT. This review summarizes recent progress in autophagy activation by SDT through multiple mechanisms in tumor therapies, drug resistance, and lipid catabolism. A promising tumor therapy, which combines SDT with autophagy inhibition using a nanoparticle delivering system, is presented and investigated.

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“…[43] To overcome this drawback, Zhang and co-workers have tried to realize the potential of Re(I)-based CO-releasing molecules (1-4) (Figure 2) in SDT. [44,45] Complex 2 displayed higher CO release than 1 because of the Cy (cyanine) ligand pendant. Cyanine moieties with more conjugation increase the π-π conjugate plane, which enhances the sonosensitivity of 2.…”

mentioning

confidence: 99%

“…These complexes released most of the Re(I)-attached CO after US irradiation, evident from gas chromatography and fluorescence studies using CO probe COP-1. [44,45] Hemoglobin (Hb) assay [46] was used to quantify the amount of CO released after US irradiation. It shows that 1.0 mole of Re complexes released ca.…”

mentioning

confidence: 99%

Metal Complexes for Cancer Sonodynamic Therapy

et al. 2022

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Sonodynamic therapy (SDT) for cancer treatment is gaining attention owing to its non‐invasive property and ultrasound‘s (US) deep tissue penetration ability. In SDT, US activates the sonosensitizer at the target deep‐seated tumors to generate reactive oxygen species (ROS), which ultimately damage tumors. However, drawbacks such as insufficient ROS production, aggregation of sonosensitizer, off‐target side effects, etc., of the current organic/nanomaterial‐based sonosensitizers limit the effectiveness of cancer SDT. Very recently, metal complexes with tunable physiochemical properties (such as sonostability, HOMO to LUMO energy gap, ROS generation ability, aqueous solubility, emission, etc.) have been devised as effective sonosensitizers, which could overcome the limitations of organic/nanomaterial‐based sonosensitizers. This concept introduces all the reported metal‐based sonosensitizers and delineates the prospects of metal complexes in cancer sonodynamic therapy. This new concept of metal‐based sonosensitizer can deliver next‐generation cancer drugs.

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An ultrasound activated cyanine-rhenium(i) complex for sonodynamic and gas synergistic therapy

Abstract: A novel cyanine-rhenium(I) tricarbonyl complex is developed as a potent sonosensitizer and sono-activatable CO-releasing agent for sonodynamic therapy (SDT) and CO gas therapy by inducing ferroptosis in cancer cells. This...

Cited by 32 publications

References 33 publications

Mechanical stimuli-driven cancer therapeutics

Mechanical stimuli-driven cancer therapeutics

The crosstalk between sonodynamic therapy and autophagy in cancer

Metal Complexes for Cancer Sonodynamic Therapy

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