An ultrasound-controllable ROS-responsive nanoplatform for O<sub>2</sub> and NO generation to enhance sonodynamic therapy against multidrug-resistant bacterial infections

Zhang, Jingyi; Zhang, Lin; Zhang, Yuhan; Ju, Rong; Wei, Guoqing

doi:10.1039/d3nr04801b

Cited by 5 publications

(1 citation statement)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The colony formation assay, adhering to the protocols established in our prior research [ 39 ], was undertaken to assess the in vitro antimicrobial properties of the biomaterials. Additionally, we sought to explore their photothermal antimicrobial capabilities by introducing MPDA and SMPDA into a bacterial suspension.…”

Section: Methodsmentioning

confidence: 99%

Injectable and Near-Infrared Light-Controllable Fibrin Hydrogels with Antimicrobial and Immunomodulating Properties for Infected Wound Healing

Zhang,

Jiang,

Zhang

et al. 2024

Biomater Res

Self Cite

View full text Add to dashboard Cite

The management of infected wounds poses a significant challenge due to the growing issue of antibiotic resistance, underscoring the urgent necessity to innovate and implement alternative therapeutic strategies. These strategies should be capable of eliminating bacterial infections in infected wounds while circumventing the induction of multi-drug resistance. In the current study, we developed an easily prepared and injectable fibrin gel (FG) loaded with nanoparticles (NPs) that exhibit antibacterial and immunomodulatory properties to facilitate the healing of infected wounds. Initially, a novel type of NP was generated through the electrostatic interaction between the photothermal agent, mPEG-modified polydopamine (MPDA), and the nitric oxide (NO) donor, S-nitrosocysteamine (SNO). This interaction resulted in the formation of NPs referred to as SNO-loaded MPDA (SMPDA). Subsequently, the SMPDA was encapsulated into the FG using a double-barreled syringe, thereby producing the SMPDA-loaded FG (SMPDA/G). Experimental results revealed that SMPDA/G could effectively eliminate bacterial infections and alter the immune microenvironment. This efficacy is attributed to the synergistic combination of NO therapy and photothermal therapy, along with the role of SMPDA in facilitating M2 macrophage polarization within the gel. Accordingly, these findings suggest that the SMPDA/G holds substantial promise for clinical application in infected wound healing.

show abstract

Section: Methodsmentioning

confidence: 99%

Injectable and Near-Infrared Light-Controllable Fibrin Hydrogels with Antimicrobial and Immunomodulating Properties for Infected Wound Healing

Zhang,

Jiang,

Zhang

et al. 2024

Biomater Res

Self Cite

View full text Add to dashboard Cite

show abstract

A Bodipy‐Based Aggregation‐Induced Emission Nanoagent for Sonodynamic Antibacterial Studies

Xu,

Tang,

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

Sonodynamic therapy (SDT) has demonstrated significant potential in addressing multidrug‐resistant bacterial infections due to its noninvasive nature and independence from antibiotics and light sources. However, the majority of current sonosensitizers exhibit aggregation‐caused quenching (ACQ), leading to low reactive oxygen species (ROS) generation efficiency. Herein, a novel nonplanar structured sonodynamic (4,4‐difluoro‐4‐boron‐3a,4‐diaza‐indandiene) BODIPY derivative, BODN, with aggregation‐induced emission (AIE) properties, and rapid generation of substantial ROS by ultrasound is introduced. The BODN is co‐assembled with the commercial amphiphilic polymer, mDSPE‐PEG2000, forming BODN nanoparticles (BODN‐NP). Under ultrasound conditions, BODN‐NP demonstrates potent antimicrobial activity and improves the inflammatory response to promote healing wounds infected by both Staphylococcus aureus and methicillin‐resistant Staphylococcus aureus. This work expands the use of AIE sonodynamic materials in antimicrobial therapy and provides new perspectives for innovative solutions against multidrug‐resistant bacterial infections.

show abstract

Stimuli‐Responsive NO Delivery Platforms for Bacterial Infection Treatment

Hu,

Ding,

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

The prevalence of drug‐resistant bacterial infections has emerged as a grave threat to clinical treatment and global human health, presenting one of the foremost challenges in medical care. Thus, there is an urgent imperative to develop safe and efficacious novel antimicrobial strategies. Nitric oxide (NO) is a recognized endogenous signaling molecule, which plays a pivotal role in numerous pathological processes. Currently, NO has garnered significant interest as an antibacterial agent due to its capability to eradicate bacteria, disrupt biofilms, and facilitate wound healing, all while circumventing the emergence of drug resistance. However, the inherently unstable characteristic of NO therapeutic gas renders the controlled administration of NO gases exceedingly challenging. Hence, in this review, the current challenge of bacterial infection is discussed; then it is briefly elucidated the antibacterial mechanism of NO and comprehensively delineate the recent advancements in stimulus‐responsive NO delivery platforms, along with their merits, obstacles, and prospective avenues for clinical application. This review offers guidance for future advancements in NO‐medicated anti‐infection therapy is hoped.

show abstract

An ultrasound-controllable ROS-responsive nanoplatform for O₂ and NO generation to enhance sonodynamic therapy against multidrug-resistant bacterial infections

Abstract: Antimicrobial sonodynamic therapy (SDT) has broad application potential in the eradication of multidrug-resistant (MDR) bacterial infections due to its non-invasiveness, absence of resistance concern, and high cytotoxicity. However, the hypoxic...

Cited by 5 publications

References 42 publications

Injectable and Near-Infrared Light-Controllable Fibrin Hydrogels with Antimicrobial and Immunomodulating Properties for Infected Wound Healing

Injectable and Near-Infrared Light-Controllable Fibrin Hydrogels with Antimicrobial and Immunomodulating Properties for Infected Wound Healing

A Bodipy‐Based Aggregation‐Induced Emission Nanoagent for Sonodynamic Antibacterial Studies

Stimuli‐Responsive NO Delivery Platforms for Bacterial Infection Treatment

Contact Info

Product

Resources

About

An ultrasound-controllable ROS-responsive nanoplatform for O2 and NO generation to enhance sonodynamic therapy against multidrug-resistant bacterial infections

Abstract: Antimicrobial sonodynamic therapy (SDT) has broad application potential in the eradication of multidrug-resistant (MDR) bacterial infections due to its non-invasiveness, absence of resistance concern, and high cytotoxicity. However, the hypoxic...

Cited by 5 publications

References 42 publications

Injectable and Near-Infrared Light-Controllable Fibrin Hydrogels with Antimicrobial and Immunomodulating Properties for Infected Wound Healing

Injectable and Near-Infrared Light-Controllable Fibrin Hydrogels with Antimicrobial and Immunomodulating Properties for Infected Wound Healing

A Bodipy‐Based Aggregation‐Induced Emission Nanoagent for Sonodynamic Antibacterial Studies

Stimuli‐Responsive NO Delivery Platforms for Bacterial Infection Treatment

Contact Info

Product

Resources

About

An ultrasound-controllable ROS-responsive nanoplatform for O₂ and NO generation to enhance sonodynamic therapy against multidrug-resistant bacterial infections