An ultrasound-triggered injectable sodium alginate scaffold loaded with electrospun microspheres for on-demand drug delivery to accelerate bone defect regeneration

Yi, Yin; Song, Jinlin; Zhou, Pengfei; Shu, Yu; Liang, Panpan; Liang, Huimin; Liu, Yanling; Yuan, Xiaoyan; Shan, Xujia; Wu, Xiaohong

doi:10.1016/j.carbpol.2024.122039

Cited by 5 publications

(1 citation statement)

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“…Sodium alginate (SA) is a naturally abundant polysaccharide derived from brown seaweeds. After extensive studies on biocompatibility, it has been proven non-toxic and non-immunogenic for various biomedical applications, such as wound healing [1,2], drug delivery [3], tissue engineering [4,5], and regenerative medicine [6]. An important feature of SA is its ability to crosslink with divalent cations like calcium ions due to rich carboxylate groups from repeating units of D-mannuronic acid (M units) and L-guluronic acid (G units).…”

Section: Introductionmentioning

confidence: 99%

Constructing Stiff β-Sheet for Self-Reinforced Alginate Fibers

Xie,

Cui,

Wang

et al. 2024

Materials

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The application of alginate fibers is limited by relatively low mechanical properties. Herein, a self-reinforcing strategy inspired by nature is proposed to fabricate alginate fibers with minimal changes in the wet-spinning process. By adapting a coagulation bath composing of CaCl2 and ethanol, the secondary structure of sodium alginate (SA) was regulated during the fibrous formation. Ethanol mainly increased the content of β-sheet in SA. Rheological analysis revealed a reinforcing mechanism of stiff β-sheet for enhanced modulus and strength. In combination with Ca2+ crosslinking, the self-reinforced alginate fibers exhibited an increment of 39.0% in tensile strength and 71.9% in toughness. This work provides fundamental understanding for β-sheet structures in polysaccharides and a subsequent self-reinforcing mechanism. It is significant for synthesizing strong and tough materials. The self-reinforcing strategy involved no extra additives and preserved the degradability of the alginate. The reinforced alginate fibers exhibited promising potentials for biological applications.

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Section: Introductionmentioning

confidence: 99%

Constructing Stiff β-Sheet for Self-Reinforced Alginate Fibers

Xie,

Cui,

Wang

et al. 2024

Materials

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Recent Strategies and Advances in Hydrogel-Based Delivery Platforms for Bone Regeneration

Wang,

Zeng,

Gan

et al. 2024

Nano-Micro Lett.

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Bioactive molecules have shown great promise for effectively regulating various bone formation processes, rendering them attractive therapeutics for bone regeneration. However, the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in vivo. Hydrogels have emerged as ideal carriers to address these challenges, offering the potential to prolong retention times at lesion sites, extend half-lives in vivo and mitigate side effects, avoid burst release, and promote adsorption under physiological conditions. This review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration, encompassing applications in cranial defect repair, femoral defect repair, periodontal bone regeneration, and bone regeneration with underlying diseases. Additionally, this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery, carrier-assisted delivery, and sequential delivery. Finally, this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

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