An ultrastructural observation of negatively-stained human immunodeficiency virus type 1 (HIV-1) cores

Abstract

Abstract. Cores of human immunodeficiency virus type 1 (HIV-i) were observed using negative staining for electron microscopy. On the surfaces of cores isolated from viral particles with a Nonidet P40 and glutaraldehyde mixture, mortar-like units were detected in the wide and narrow margins. In some of the cores which were burst with distilled water, the units were linked together revealing a beaded structure.