An ultrastructural study of the origin and function of basophilic degeneration in human cardiac muscle—cardiac colloid. Type 1

Gregory, Michael; Olmesdahl, P J; Whitton, I. D.

doi:10.1002/path.1711380405

Cited by 5 publications

(2 citation statements)

References 17 publications

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“…In addition, basophilic inclusion areas (which denote areas of acute muscle ischaemia) and muscle accretion (a sign of sarcolemmal nuclear proliferation leading to muscle regeneration) were quantified. Basophilic inclusion areas were first described in rheumatic heart disease in 190624, but for a more comprehensive review see Gregory and co‐workers25. Quantification was done by counting the pathological changes (i.e.…”

Section: Methodsmentioning

confidence: 99%

Cellular pathology changes in rat skin following intradermal injection of nerve growth factor: neutrophil‐dependent and ‐independent events

Foster

Wicks²,

Foster³

et al. 2002

The Journal of Pathology

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Nerve growth factor (NGF) regulates the survival and development of specific populations of neurones and is involved in wound healing. A further area of study relating to the role of neurotrophins in the mature animal has concerned the possibility that NGF may be a pivotal mediator of inflammation and pain. It has previously been shown that injection of intradermal NGF can result in a neutrophil-dependent hyperalgesia in the rat. The purpose of the present study was to examine the pathological consequence of NGF injected intradermally into mature rat skin and to examine further the role of neutrophils. Standard histopathology techniques (H & E) were employed to determine inflammatory cell counts. Circulating neutrophils were depleted using an anti-rat neutrophil antiserum and results were compared to treatment with vehicle controls. Saline-pretreated rats exhibited normal circulating neutrophil numbers and the dorsal skin showed a significant increase of neutrophil and macrophages at 3 and 5 h and lymphocytes at 5 h after NGF treatment. By comparison, skin sites from neutrophil-depleted rats did not demonstrate a significant increase in neutrophil and macrophage accumulation after NGF administration. All NGF-treated sites, independent of pretreatment, demonstrated abnormal muscle fibre morphology and proliferation of the muscle sarcolemmal nuclei after NGF injection, indicative of tissue injury. In addition, oedema and some fibroplasia were also noted. Furthermore, fibrin production was increased at 3 and 5 h after NGF administration. It is suggested that NGF has a damaging effect on rat muscle which is independent of accumulating neutrophil and other inflammatory cells. In conclusion, the findings indicate a link between NGF-induced neutrophil and macrophage accumulation, as the increase in dermal macrophages was not observed in neutrophil-depleted rats. The results also suggest that NGF can have a profound effect on rat muscle and that this effect may be related to muscle regeneration.

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Section: Methodsmentioning

confidence: 99%

Cellular pathology changes in rat skin following intradermal injection of nerve growth factor: neutrophil‐dependent and ‐independent events

Foster

Wicks²,

Foster³

et al. 2002

The Journal of Pathology

View full text Add to dashboard Cite

show abstract

“…Basophilic swollen myocardial cells with altered myofibrils (myxoid degeneration) has been regarded as an age-specific degenerative process, 59 but is extensively seen in diseased hearts at any age, and is by no means universal 'Restriction of calorie intake by about 40% of ad libitum fed animals significantly increases lifespan and retards many aging phenomena in several experimental species. in old age.…”

Section: Other Microscopic Changes In the Myocardiummentioning

confidence: 99%