An ultrastructural study of the relationship of oral bacteria to the epithelium of healing tooth extraction wounds

McMillan, M.D.

doi:10.1016/0003-9969(75)90059-x

Cited by 6 publications

(1 citation statement)

References 46 publications

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“…ONJ uniquely occurs in the jaw but not in long bones [29]. Tooth extraction wounds are different from tibial osseous wounds in that (1) they are open wounds exposed to the oral cavity where numerous oral pathogens inhabit and dense bacterial colonization occurs [30], (2) the extraction wounds are subjected to repeated mechanical trauma from chewing, (3) the extraction sockets are surrounded by dense bundle bone while the tibial wounds are exposed to the abundance of the bone marrow milieu, (4) the embryologic origin of the maxillae and mandibles (pharyngeal arch 1) is distinct from long bones [31], and (5) the bone formation pattern of the alveolar bone is different from that of long bones (intramembranous vs. endochondral bone formation) [32]. Considering these differences, tooth extraction wound healing appears to be distinct from long bone wound healing.…”

Section: Discussionmentioning

confidence: 99%

Early effects of parathyroid hormone on bisphosphonate/steroid-associated compromised osseous wound healing

et al. 2013

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SummaryAdministration of intermittent parathyroid hormone (PTH) promoted healing of tibial osseous defects and tooth extraction wounds and prevented the development of necrotic lesions in rats on a combined bisphosphonate and steroid regimen.IntroductionOsteonecrosis of the jaw (ONJ) has emerged in association with antiresorptive therapies. The pathophysiology of ONJ is unknown and no established cure currently exists. Our objective was to determine the effect of intermittent PTH administration on early osseous healing in the jaw and long bones of rats receiving bisphosphonate and steroid treatment.MethodsOvariectomized rats received the combination therapy of alendronate and dexamethasone (ALN/DEX) for 12 weeks. Osseous wounds were created in the jaw and tibia. PTH was administered intermittently and healing at 2 weeks post-op was compared between the jaw and tibia by microcomputed tomography and histomorphometric analyses.ResultsALN/DEX treatment was associated with necrotic open wounds in the jaw but had no negative effects on healing and promoted bone fill in tibial defects. PTH therapy prevented the development of necrotic lesions in the jaw and promoted healing of the tibial defects. PTH therapy was associated with the promotion of osteocyte survival in osseous wounds both in the jaw and tibia.ConclusionsWound healing was impaired in the jaw in rats on a combined bisphosphonate and steroid regimen, and PTH therapy rescued necrotic lesions. These findings suggest that PTH therapy could be utilized to prevent ONJ from occurring in patients on combination antiresorptive and steroid therapy.

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Section: Discussionmentioning

confidence: 99%

Early effects of parathyroid hormone on bisphosphonate/steroid-associated compromised osseous wound healing

et al. 2013

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Differential modulation of zoledronate and etidronate in osseous healing of an extracted socket and tibia defect

Lim

Lee

Kim

et al. 2017

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Neutrophils in the molar tooth extraction wound in the rat: a transmission electron microscope (TEM) study

McMillan

1999

J Oral Pathology Medicine

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Neutrophils have been ascribed a number of functions from ultrastructural studies of healing wounds. All of the wounds so far examined have been relatively aseptic. This study investigates, by TEM, the structure of neutrophils in healing molar tooth sockets in rats. Prior to epithelial coverage, a dense infiltrate of neutrophils separated the viable wound tissues from the overlying debris and bacteria. The more deeply situated neutrophils contained many granules and only occasional phagosomes. More superficial neutrophils contained fewer granules and phagosomes with engulfed bacteria undergoing lysis. The most superficial neutrophils were degenerate, lacked granules and often contained viable bacteria. There were varying numbers of neutrophils containing granules in the blood clot, granulation tissue, wound epithelium and adjacent tissue. No extracellular neutrophil granules nor extracellular discharge of granules was found. These findings differ from those of previous ultrastructural studies of relatively aseptic healing wounds. Ultrastructurally, the only function of neutrophils in healing tooth extraction wounds appears to be phagocytosis of bacteria, which supports a role in the prevention of infection.

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An ultrastructural study of the relationship of oral bacteria to the epithelium of healing tooth extraction wounds

Cited by 6 publications

References 46 publications

Early effects of parathyroid hormone on bisphosphonate/steroid-associated compromised osseous wound healing

Early effects of parathyroid hormone on bisphosphonate/steroid-associated compromised osseous wound healing

Differential modulation of zoledronate and etidronate in osseous healing of an extracted socket and tibia defect

Neutrophils in the molar tooth extraction wound in the rat: a transmission electron microscope (TEM) study

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