An Ultrastructural Study of the Bone-titanium Interface Using Pure Titanium-coated Plastic and Pure Titanium Rod Implants.

Ayukawa, Yasunori; Takeshita, Fumitaka; Inoue, Takashi; Yoshinari, Masao; Ohtsuka, Yoshiro; Murai, K; Shimono, Masaki; Suetsugu, Tsuneo; Takano, Teruo

doi:10.1267/ahc.29.243

Cited by 22 publications

(35 citation statements)

References 22 publications

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“…Specimens were decalcified in a solution containing 5% EDTA and 4% saccharose for 1 month. Then the tibia was cut off carefully with a razor blade along the long axis of the Ti cylinder to take it out 26. The removed cylinders were observed under incident‐light microscope to check for tissue remnants on the surfaces.…”

Section: Methodsmentioning

confidence: 99%

Tissue–response to calcium‐bonded titanium surface

Zhang

Ayukawa

LeGeros

et al. 2010

J Biomedical Materials Res

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Our previous study demonstrated that calcium-bonded titanium surface (Ca-Ti) can be obtained by hydrothermal reaction between titanium (Ti) and CaCl(2) and that bone-apatite like formation was observed after immersion in simulated body fluid. The purpose of the study was to determine the in vivo response to Ca-Ti surface using a rodent tibia model. Cylinders of commercially pure Ti were divided into three groups: (1) untreated group; (2) NaOH+hTi group: soaked in 5 mol/L NaOH solution at 60 degrees C then heated at 400 degrees C for 1 h; and (3) Ca-Ti group: hydrothermally treated in the presence of 10 mmol/L CaCl(2) at 200 degrees C for 24 h. The cylinders implanted in surgically created defects in tibias of 8-week old male Wistar rats were retrieved after 1, 2, and 4 weeks. Histomorphometric evaluations were made on stained decalcified thin sections. Results showed that at 1, 2, and 4 week after implantation, respectively, bone contact was 55.2 +/- 16.4%, 88.1 +/- 9.9%, and 96.1 +/- 4.8% for Ca-Ti implants, 5.7 +/- 5.3%, 19.9 +/- 1.2%, 57.4 +/- 4.8% for untreated; and 27.2 +/- 0.7%, 70.9 +/- 7.7%, and 96.0 +/- 5.1% for NaOH+hTi implants. These results suggest that hydrothermal treatment with CaCl(2) provides a bioactive Ca-Ti bonded surface that allows bone formation greater than that obtained with NaOH+heat treated Ti surfaces.

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Section: Methodsmentioning

confidence: 99%

Tissue–response to calcium‐bonded titanium surface

Zhang

Ayukawa

LeGeros

et al. 2010

J Biomedical Materials Res

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“…It has been used successfully as an adjunct to calcium phosphate based bone cements, predominately in mandibular defects at extraction sites [24,25]. Scanning electron microscopy revealed an amorphous proteoglycan layer at titanium surfaces as a prerequisite for cell attachment [26]. Precoating of titanium implants with glycosaminoglycans as active functional proteoglycan side chains therefore appears attractive to enhance bone healing around such implants.…”

Section: Introductionmentioning

confidence: 99%

Coating of titanium implants with collagen, RGD peptide and chondroitin sulfate

et al. 2006

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“…The results have shown that rapid, strong osseointegration can be achieved with implants having surface roughness in the order of Sa=2 μm [1][2][3] . However, since the implant body is metal, tissue samples cannot readily be prepared, and, therefore, the tissue reaction at the titanium-bone interface cannot be easily evaluated 9,[13][14][15] .…”

Section: Discussionmentioning

confidence: 99%

The Effects of Implant Surface Characteristics on Surrounding Bone: A Comparative Study of Two Types of Surface Characteristics

Yamamoto

Yanagi

Watazu

et al. 2014

J. Hard Tissue Biology.

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The aims of this study were to create experimental implants by coating rough plastic surfaces with a thin layer of titanium, and to use the experimental implants in an animal experiment to investigate whether differences in the surface characteristics of the implant affect the peri-implant bone reaction during the period of osseointegration. Titanium rods of diameter 1.6 mm and length 7 mm were treated by acid etching (AE) or sandblasting followed by acid etching (SA), and replicas were made from plastic. Experimental implants were created by depositing a thin layer of titanium on the plastic replicas by DC-magnetron sputtering, and the surface characteristics of the experimental implants were evaluated. The experimental implants were placed in the tibias of eight-week-old male SD rats. The rats were sacrificed and the implants harvested at 3, 5, 10, 14, 21 and 28 days after implant placement. The samples were examined by optical microscopy and micro-CT to confirm peri-implant new bone growth. Examination of the experimental implants by SEM imaging showed that the different surface conditions (SA and AE) had been faithfully recreated. TEM observation and XPS analysis confirmed that the coating was titanium. The surface roughness of SA and AE was 2.68±0.536 μm and 0.47±0.069 μm, respectively. With AE, the BMD of peri-implant trabecular bone showed that bone mineralization progressed not on the surface of the implant but at sites a small distance away. At day 28 after placement of the implant, when osseointegration was complete, the BMD value in the region near the implant surface was higher in SA than in AE. Furthermore, the BV/TV value was high at an earlier stage in SA than AE. The results showed that the SA surface was better than the AE surface for achieving osseointegration.

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An Ultrastructural Study of the Bone-titanium Interface Using Pure Titanium-coated Plastic and Pure Titanium Rod Implants.

Cited by 22 publications

References 22 publications

Tissue–response to calcium‐bonded titanium surface

Tissue–response to calcium‐bonded titanium surface

Coating of titanium implants with collagen, RGD peptide and chondroitin sulfate

The Effects of Implant Surface Characteristics on Surrounding Bone: A Comparative Study of Two Types of Surface Characteristics

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