An umbrella review of the evidence linking oral health and systemic noncommunicable diseases

Botelho, João; Mascarenhas, Paulo; Viana, João; Proença, Luís; Orlandi, Marco; Leira, Yago; Mendes, José João; Machado, Vanessa

doi:10.1038/s41467-022-35337-8

Cited by 91 publications

(45 citation statements)

References 57 publications

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“…Hence, a direct biological effect of lifestyle behaviours on the periodontium is suggested. These findings may be relevant for clinicians because those behaviours may represent potential targets of interventions in the context of the Step 1 of periodontal therapy (Sanz et al, 2020), and for researchers because they may represent potential confounders to be considered when analysing the risk factors of periodontitis or its association with systemic diseases (Antonoglou et al, 2023; Baima et al, 2022; Botelho et al, 2022; D'Aiuto et al, 2018; Marruganti, Baima, Aimetti, et al, 2023; Marruganti, Shin, Jim, et al, 2023; Romandini et al, 2020, 2021).…”

Section: Discussionmentioning

confidence: 99%

Healthy lifestyles are associated with a better response to periodontal therapy: A prospective cohort study

Marruganti

Romandini

Gaeta

et al. 2023

J Clinic Periodontology

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Aim To evaluate the association between lifestyle behaviours and clinical periodontal outcomes following Steps 1/2 of periodontal therapy. Methods A total of 120 subjects with untreated Stage II/III periodontitis participated in this study. At baseline, questionnaires were administered to assess the following lifestyle behaviours: adherence to Mediterranean diet (MD), physical activity (PA) and stress levels, sleep quality, smoking and alcohol use. Participants received Steps 1/2 of periodontal therapy and were re‐evaluated after 3 months. A composite outcome of the endpoint of therapy (i.e., no sites with probing pocket depth [PPD] ≥4 mm with bleeding on probing, and no sites with PPD ≥ 6 mm) was regarded as the primary outcome. Simple and multiple regression analyses were used to evaluate the association between lifestyle behaviours and clinical periodontal outcomes. Disease severity at baseline, body mass index, diabetes, household disposable income and plaque control were considered as confounders. Results Multiple regression analyses showed significantly lower odds of achieving the endpoint of therapy in subjects with poor sleep quality (odds ratio [OR] = 0.13; 95% confidence interval [CI]: 0.03–0.47; p < .01), smoking (OR = 0.18; 95% CI: 0.06–0.52; p < .05) and alcohol use above the suggested intake (OR = 0.21; 95% CI: 0.07–0.63; p < .01). Subjects with a combination of ‘unhealthy lifestyles’ (low adherence to MD and low PA levels and high levels of stress and poor sleep quality) showed higher proportions of residual PPD≥6 mm (MD = 1.51; 95% CI: 0.23–2.80; p < .05) and lower odds of achieving the endpoint of therapy (OR = 0.85; 95% CI: 0.33–0.99; p < .05) at re‐evaluation. Conclusions Subjects with unhealthy lifestyle behaviours showed worse clinical outcomes 3 months after Steps 1/2 of periodontal therapy.

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Section: Discussionmentioning

confidence: 99%

Healthy lifestyles are associated with a better response to periodontal therapy: A prospective cohort study

Marruganti

Romandini

Gaeta

et al. 2023

J Clinic Periodontology

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“…З одного боку, виникнення і перебіг захворювань органів і тканин порожнини рота залежать від тяжкості системних захворювань. З іншого боку, існує доказова база, що свідчить про негативний вплив стоматологічних захворювань на перебіг соматичної патології, на розвиток вогнищево зумовлених захворювань організму [1][2][3].…”

Section: робота є фрагментом ндр за державним замовленням «внесок ком...unclassified

Features of the Interrelationship of Periodontal Diseases and Somatic Diseases (Literature Review)

Vasko

Tkachenko

2023

Ukr. Dent. Alm.

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The interrelationship of periodontal diseases and somatic diseases has a two-way aggravating character. An analysis of modern scientific literature concerning the connection between periodontal diseases and systemic diseases of the human body has been realized. To collect information for this review, a search was conducted for the scientific literature presented in three databases (Pubmed, Scopus, Web of Science) for the past 2 years. Thirty-four studies, including reviews and original articles, were selected for qualitative analysis based on their relevance to the main content of this review. Numerous studies confirm the significant relationship between the severity of the course of oral inflammatory diseases, the state of its microbiome and the unfavorable prognosis of cardiovascular diseases, diseases of the respiratory system, metabolic syndrome, obesity, rheumatoid arthritis, etc. The presence of periodontitis in patients increases the risk of developing cardiovascular diseases, particularly coronary heart disease and stroke. A high prevalence of periodontal tissue diseases in people with chronic diseases of the digestive organs is noted, which is associated with a violation of all types of metabolism. Severe forms of periodontitis often coexist with diabetes of the first and second types and are considered the most frequent complications of diabetes. Recent studies have clearly substantiated the role of certain periodontal pathogenic microorganisms in the etiopathogenesis and complicated course of rheumatoid arthritis. Highly pathogenic microorganisms of the oral cavity, penetrating through the damaged epithelium of the vascular wall of the periodontal tissues into the systemic circulation, cause chronic bacteremia and affect distant organs and tissues. Since we cannot directly influence on the function of definite organs, it is advisable to prescribe not only basic periodontal treatment, but also the drugs that affect the vascular component of the inflammatory process, namely, strengthen the vascular wall and improve microcirculatory channel trophicity.

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“…Poor OH can have a significant impact on older people’s general health and well-being. Several studies point out the associations between poor oral function and oral diseases and an increased risk of diabetes, cardiovascular disease, aspiration pneumonia, and cognitive impairment (Saito et al 2018; de Almeida Mello et al 2019; Fiorillo 2019; Strait et al 2021; Botelho et al 2022; Liu et al 2022). To counter such health issues, adequate daily oral hygiene and regular oral checkups are important (Morgan et al 2016).…”

Section: Introductionmentioning

confidence: 99%

International Delphi Study to Optimize the Oral Health Section in interRAI

et al. 2023

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Introduction: The oral health (OH) of care-dependent older people is generally poor. Since caregivers are mainly responsible for older people’s daily care, they can be considered important intermediaries to improve their OH by performing regular OH assessments. The interRAI instruments are introduced in 37 countries to assess care needs and facilitate care planning across different health care settings. The oral health section (OHS) within the interRAI instrument used in long-term care facilities was optimized for the Belgian context to identify residents who need assistance with daily oral care and/or need to be referred to a dentist. This Delphi study evaluated whether the OHS is also relevant and useful in other countries and modified the OHS accordingly until an international consensus was reached. Participants were experts in OH for older people. During 2 rounds of online questionnaires, experts rated the content, assessment process, triggering of Clinical Assessment Protocols, and accompanying guidelines and instruction videos of the optimized OHS. Based on the experts’ comments and suggestions collected during the first round, the OHS was adjusted and presented to the experts in the second round for re-evaluation. The first and second questionnaires were completed by 48 and 42 oral health experts from 29 and 27 countries where the interRAI instruments are introduced, respectively. Five experts from 5 countries where interRAI is not introduced also participated in both rounds. After the second round, a consensus of over 86% was reached on all criteria. International consensus on the OHS was reached, considering national and cultural differences that may affect OH. The next step in this research is to evaluate the assessment process to identify potential barriers and facilitators to achieving reliable OH assessments internationally. Furthermore, the effect of the OHS at the level of the resident and of the caregivers will be evaluated.

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An umbrella review of the evidence linking oral health and systemic noncommunicable diseases

Cited by 91 publications

References 57 publications

Healthy lifestyles are associated with a better response to periodontal therapy: A prospective cohort study

Healthy lifestyles are associated with a better response to periodontal therapy: A prospective cohort study

Features of the Interrelationship of Periodontal Diseases and Somatic Diseases (Literature Review)

International Delphi Study to Optimize the Oral Health Section in interRAI

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