An Uncommon Cause of Diffuse Alveolar Haemorrhage

Gartner, Birgit; Jacquier, Lionel; Petignat, Pierre-Auguste; Rochat, Thierry

doi:10.1159/000105541

Cited by 2 publications

(1 citation statement)

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“…This resemblance possibly argues more for a role of canines as victims of infection rather than culprits for its spread [19]. Furthermore, in view of the discrepant incidence of clinical disease between various species in some countries, we suggest that the dog may be an indicator of the presence of Leptospira interrogans in the environment [22]. …”

Section: Introductionmentioning

confidence: 99%

Increasing Incidence of Canine Leptospirosis in Switzerland

Major

Schweighauser

Francey

2014

IJERPH

140

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A marked increase in canine leptospirosis was observed in Switzerland over 10 years with a peak incidence of 28.1 diagnosed cases/100,000 dogs/year in the most affected canton. With 95% affected dogs living at altitudes <800 m, the disease presented a seasonal pattern associated with temperature (r2 0.73) and rainfall (r2 0.39), >90% cases being diagnosed between May and October. The increasing yearly incidence however was only weakly correlated with climatic data including number of summer (r2 0.25) or rainy days (r2 0.38). Serovars Australis and Bratislava showed the highest seropositivity rates with 70.5% and 69.1%, respectively. Main clinical manifestations included renal (99.6%), pulmonary (76.7%), hepatic (26.0%), and hemorrhagic syndromes (18.2%), leading to a high mortality rate (43.3%). Similar to the human disease, liver involvement had the strongest association with negative outcome (OR 16.3). Based on these data, canine leptospirosis presents similar features and severity as the human infection for which it therefore can be considered a model. Its re-emergence in a temperate country with very high incidence rates in canines should thus be viewed as a warning and emphasize the need for increased awareness in other species.

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Section: Introductionmentioning

confidence: 99%