An Uncommon Cause of Dysphagia: Postpneumonectomy Syndrome

Rego, Erica; Abdelmeguid, Ahmed S.; Wang, Yuqi Kevin; Dewan, Karuna

doi:10.1155/2021/6658690

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…As secondary causes of similar symptoms include spondylosis deformans in the elderly and left pneumonectomy for lung cancer. 8,9 In this literature, anorexia due to esophageal deviation has been reported. In our study, upper gastrointestinal endoscopy and pH monitoring of the esophagus were not actually performed, but we speculated that a similar mechanism might have exacerbated the side effects of oral adjuvant chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Impact of thoracic esophageal displacement after lobectomy on the continuity of oral adjuvant chemotherapy

Okamoto

Kaku

Oshio

et al. 2022

Asian Cardiovasc Thorac Ann

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Background Adjuvant tegafur-uracil therapy has prolonged postoperative survival in patients with non-small cell lung cancer. Some patients experience treatment discontinuation due to gastrointestinal disorders such as anorexia, and the associated factors and the impact of lobectomy remain unclear. This study aimed to assess the postoperative esophageal displacement after lobectomy and to clarify its impact on the continuity of tegafur-uracil treatment. Methods Patients who received adjuvant tegafur-uracil therapy after lobectomy between April 2009 and March 2019 were retrospectively analyzed. Patient background, perioperative characteristics, treatment findings, and the degree of esophageal displacement measured by computed tomography were compared between the treatment completion group and the discontinuation group. A subgroup comparative analysis was further performed in the groups divided according to the degree of esophageal displacement. Results A total of 68 patients were reviewed, including 41 males and 27 females with a mean age of 66.2 years old. A total of 41 patients completed the 2-year adjuvant treatment and 27 patients discontinued it. The overall survival and relapse-free survival between the two groups were statistically significant ( p = 0.027, p = 0.010). The degree of esophageal displacement at the Th7 level was a significant predictor of treatment discontinuation ( p = 0.046, odds ratio [OR]: 1.138, 95% confidence interval [CI]: 1.002–1.291). Among the patients with a high degree of esophageal displacement above the baseline determined from the receiver operating characteristic curve, the cause of discontinuation was anorexia, which was significant in multivariate analysis ( p = 0.013, OR: 14.72, 95% CI: 1.745–124.2). Conclusions Our study suggested that anatomical displacement of the esophagus after lobectomy may affect the discontinuation of oral adjuvant chemotherapy in patients with lung cancer.

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Section: Discussionmentioning

confidence: 99%

Impact of thoracic esophageal displacement after lobectomy on the continuity of oral adjuvant chemotherapy

Okamoto

Kaku

Oshio

et al. 2022

Asian Cardiovasc Thorac Ann

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Medical conditions associated with concurrent dysphagia and dysphonia

Myszel,

Henryk Skarzynski

2024

Swallowing - Problems and Management [Working Title]

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Swallowing and voice production are important processes enabling a comfortable life. For appropriate alimentation, effective passage of food and fluids through a digestive system is necessary. Interpersonal communication depends on good voice and speech. Conditions associated with swallowing and speech problems leads dysfunctions and seriously affect the patient’s comfort of living. This chapter is a review of medical conditions associated with concurrence of dysphonia and dysphagia. There are a large number of medical conditions leading to the simultaneous occurrence of swallowing problems and hoarseness. The diversity of disorders is a serious interdisciplinary issue. Diagnostics of concurrent dysphagia and dysphonia is complicated and requires a holistic interdisciplinary approach. The reasons include functional and organic dysfunctions, neurological conditions, tumors, vascular disorders, autoimmune inflammations, post-operative complications, post-COVID complications, and others. Our research was conducted by reviewing PubMed and Scopus network using key words “dysphagia”, “dysphonia”, “hoarseness.” We found 966 publications, then narrowed the search to 99 articles describing medical conditions and case reports, which present with dysphagia and dysphonia occurring together. Detailed analysis enabled us to categorize the disorders into groups, depending on characteristics and body region involved in the pathological process. Finally, the description of the medical conditions was done systematically according to those groups.

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An Uncommon Cause of Dysphagia: Postpneumonectomy Syndrome

Cited by 2 publications

References 9 publications

Impact of thoracic esophageal displacement after lobectomy on the continuity of oral adjuvant chemotherapy

Impact of thoracic esophageal displacement after lobectomy on the continuity of oral adjuvant chemotherapy

Medical conditions associated with concurrent dysphagia and dysphonia

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